STRINGSTRING
ITGA4 ITGA4 ARHGAP35 ARHGAP35 ITGAM ITGAM FGF9 FGF9 CXCR4 CXCR4 PPP1CB PPP1CB DIAPH3 DIAPH3 CHRM2 CHRM2 RAC3 RAC3 CFL2 CFL2 ARHGEF7 ARHGEF7 CHRM4 CHRM4 RAF1 RAF1 LPAR5 LPAR5 ENSSBOP00000003528 ENSSBOP00000003528 ARPC1B ARPC1B PPP1R12C PPP1R12C ARAF ARAF ITGA3 ITGA3 ENSSBOP00000005039 ENSSBOP00000005039 ARPC3 ARPC3 ARPC4 ARPC4 FGF10 FGF10 LPAR4 LPAR4 ITGAX ITGAX ITGB2 ITGB2 PIK3CA PIK3CA IQGAP2 IQGAP2 ITGB5 ITGB5 FGF4 FGF4 SSH2 SSH2 FGF5 FGF5 DOCK1 DOCK1 F2 F2 PIK3CB PIK3CB ARHGEF12 ARHGEF12 NRAS NRAS TMSB4Y TMSB4Y GNA12 GNA12 RRAS RRAS RAC2 RAC2 ITGAV ITGAV IQGAP3 IQGAP3 PTK2 PTK2 CHRM1 CHRM1 NCKAP1L NCKAP1L ENSSBOP00000010668 ENSSBOP00000010668 KRAS KRAS WASF2 WASF2 ITGAD ITGAD PDGFRA PDGFRA ITGB7 ITGB7 BDKRB2 BDKRB2 FGF1 FGF1 MAP2K1 MAP2K1 MRAS MRAS HRAS HRAS TIAM1 TIAM1 GNG12 GNG12 MYL10 MYL10 IQGAP1 IQGAP1 ITGB1 ITGB1 FGF18 FGF18 FGFR4 FGFR4 VAV2 VAV2 LIMK2 LIMK2 RAC1 RAC1 PIK3R3 PIK3R3 FGF6 FGF6 PDGFRB PDGFRB EZR EZR CRKL CRKL LPAR1 LPAR1 CDC42 CDC42 SPATA13 SPATA13 MYH11 MYH11 PDGFA PDGFA MYLK4 MYLK4 WASF1 WASF1 CFL1 CFL1 ITGA2 ITGA2 DIAPH1 DIAPH1 ARPC5L ARPC5L ROCK2 ROCK2 CYFIP2 CYFIP2 KNG1 KNG1 FGF8 FGF8 MYL2 MYL2 ARPC5 ARPC5 FGF23 FGF23 PDGFD PDGFD ITGA10 ITGA10 PAK6 PAK6 DIAPH2 DIAPH2 PIP5K1B PIP5K1B MYLK2 MYLK2 PFN1 PFN1 PIP5K1C PIP5K1C ITGA2B ITGA2B EGFR EGFR SOS2 SOS2 FGF3 FGF3 ITGB8 ITGB8 RHOC RHOC MAPK1 MAPK1 FGFR3 FGFR3 SOS1 SOS1 ACTN1 ACTN1 LPAR2 LPAR2 FGF7 FGF7 ITGA9 ITGA9 ITGB3 ITGB3 PAK5 PAK5 ITGB6 ITGB6 GSN GSN SCIN SCIN SRC SRC ACTN4 ACTN4 ITGAL ITGAL GIT1 GIT1 PDGFB PDGFB FGF20 FGF20 CXCL12 CXCL12 PAK4 PAK4 MAPK3 MAPK3 FGF2 FGF2 ITGA11 ITGA11 PFN4 PFN4 MYH9 MYH9 FN1 FN1 NCKAP1 NCKAP1 ARHGEF6 ARHGEF6 ITGA7 ITGA7 RDX RDX RRAS2 RRAS2 PIKFYVE PIKFYVE BAIAP2 BAIAP2 ARPC2 ARPC2 GNA13 GNA13 BCAR1 BCAR1 INS INS FGF16 FGF16 ENSSBOP00000032178 ENSSBOP00000032178 FGF19 FGF19 FGF21 FGF21 ITGA6 ITGA6 PIP4K2A PIP4K2A MYLPF MYLPF PIP4K2C PIP4K2C PIP5K1A PIP5K1A CRK CRK F2R F2R MAP2K2 MAP2K2 MYLK3 MYLK3 PPP1R12A PPP1R12A PAK2 PAK2 MSN MSN ACTB ACTB INSRR INSRR PIK3R2 PIK3R2 SLC9A1 SLC9A1 VAV1 VAV1 ROCK1 ROCK1 SSH3 SSH3 PAK1 PAK1 WASL WASL PPP1CC PPP1CC APC APC BRK1 BRK1 PIK3R1 PIK3R1 MYL9 MYL9 ITGA1 ITGA1 PFN2 PFN2 SSH1 SSH1 ITGB4 ITGB4 VAV3 VAV3 ITGA8 ITGA8 MYH10 MYH10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
ARHGAP35Rho GTPase activating protein 35. (1514 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1282 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (392 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
DIAPH3Diaphanous related formin 3. (1193 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (482 aa)
RAC3Rac family small GTPase 3. (311 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (780 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (371 aa)
ENSSBOP00000003528Uncharacterized protein. (1061 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (425 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (692 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1069 aa)
ENSSBOP00000005039Uncharacterized protein. (178 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (170 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (227 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1121 aa)
ITGB2Integrin beta. (769 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1472 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (875 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SSH2Slingshot protein phosphatase 2. (1448 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1752 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (621 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1091 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TMSB4YThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
GNA12G protein subunit alpha 12. (318 aa)
RRASRAS related. (218 aa)
RAC2Rac family small GTPase 2. (192 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1056 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1561 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (979 aa)
CHRM1Cholinergic receptor muscarinic 1. (393 aa)
NCKAP1LNCK associated protein 1 like. (1035 aa)
ENSSBOP00000010668Uncharacterized protein. (129 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
WASF2WASP family member 2. (498 aa)
ITGADIntegrin subunit alpha D; Belongs to the integrin alpha chain family. (1161 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (867 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (389 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
MYL10Myosin light chain 10. (230 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1673 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
LIMK2LIM domain kinase 2. (638 aa)
RAC1Uncharacterized protein. (207 aa)
PIK3R3Uncharacterized protein. (461 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
EZREzrin. (586 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
LPAR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa)
CDC42Uncharacterized protein. (191 aa)
SPATA13Uncharacterized protein. (1332 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1996 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (444 aa)
WASF1WASP family member 1. (559 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (175 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
DIAPH1Diaphanous related formin 1. (1266 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
KNG1Kininogen 1. (644 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
MYL2Myosin light chain 2. (165 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
PAK6Non-specific serine/threonine protein kinase. (706 aa)
DIAPH2Uncharacterized protein. (116 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (675 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1038 aa)
EGFRReceptor protein-tyrosine kinase. (1196 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1283 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (770 aa)
RHOCUncharacterized protein. (100 aa)
MAPK1Mitogen-activated protein kinase 1. (305 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
ACTN1Actinin alpha 1. (914 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (991 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (800 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GSNGelsolin. (767 aa)
SCINScinderin. (715 aa)
SRCTyrosine-protein kinase. (542 aa)
ACTN4Actinin alpha 4. (930 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1170 aa)
GIT1GIT ArfGAP 1. (766 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
FN1Fibronectin 1. (2478 aa)
NCKAP1NCK associated protein 1. (1110 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
RDXRadixin. (603 aa)
RRAS2RAS related 2. (168 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
BAIAP2BAI1 associated protein 2. (531 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
GNA13G protein subunit alpha 13. (282 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (917 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSSBOP00000032178Uncharacterized protein. (185 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1129 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
PIP5K1APIPK domain-containing protein. (437 aa)
CRKCRK proto-oncogene, adaptor protein. (249 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (417 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
MSNFERM domain-containing protein. (577 aa)
ACTBActin beta. (378 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
PIK3R2Uncharacterized protein. (674 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
VAV1Vav guanine nucleotide exchange factor 1. (875 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
SSH3Slingshot protein phosphatase 3. (652 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
WASLWASP like actin nucleation promoting factor. (507 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
APCAPC regulator of WNT signaling pathway. (2843 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (727 aa)
MYL9Myosin light chain 9. (172 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1174 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
SSH1Slingshot protein phosphatase 1. (1006 aa)
ITGB4Integrin beta. (1838 aa)
VAV3Vav guanine nucleotide exchange factor 3. (844 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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