(60 nodes) Cortisol synthesis and secretion network (Saimiri boliviensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (551 aa)
	ENSSBOP00000002529	Uncharacterized protein. (247 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1880 aa)
	GNA11	G protein subunit alpha 11. (358 aa)
	PBX1	PBX homeobox 1. (430 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	CACNA1H	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2291 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (507 aa)
	PDE8B	Phosphodiesterase. (885 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	GNAQ	G protein subunit alpha q. (301 aa)
	ATF6B	Activating transcription factor 6 beta. (689 aa)
	PDE8A	Phosphodiesterase. (793 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
	SP1	Sp1 transcription factor. (726 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2673 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (467 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2747 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (641 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1981 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (486 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (507 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1257 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	ENSSBOP00000023407	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (372 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
	LDLR	Low density lipoprotein receptor. (569 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (205 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	MRAP	Melanocortin 2 receptor accessory protein. (174 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
	CREB3	cAMP responsive element binding protein 3. (371 aa)
	POMC	Proopiomelanocortin. (269 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (443 aa)
	GNAS	GNAS complex locus. (897 aa)
	ENSSBOP00000032057	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (490 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (470 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1229 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (413 aa)
	CACNA1G	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSSBOP00000033334	ENSSBOP00000018241	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.479
ADCY1	ADCY3	ENSSBOP00000033334	ENSSBOP00000010452	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.945
ADCY1	ADCY4	ENSSBOP00000033334	ENSSBOP00000038607	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.468
ADCY1	ADCY5	ENSSBOP00000033334	ENSSBOP00000019426	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.473
ADCY1	ADCY6	ENSSBOP00000033334	ENSSBOP00000022198	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.474
ADCY1	ADCY7	ENSSBOP00000033334	ENSSBOP00000027520	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.507
ADCY1	ADCY8	ENSSBOP00000033334	ENSSBOP00000015244	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.953
ADCY1	ADCY9	ENSSBOP00000033334	ENSSBOP00000040588	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.656
ADCY1	CACNA1G	ENSSBOP00000033334	ENSSBOP00000040010	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.603
ADCY1	ENSSBOP00000002529	ENSSBOP00000033334	ENSSBOP00000002529	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.901
ADCY1	GNAS	ENSSBOP00000033334	ENSSBOP00000031844	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.971
ADCY1	PDE8A	ENSSBOP00000033334	ENSSBOP00000009965	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.667
ADCY1	PDE8B	ENSSBOP00000033334	ENSSBOP00000007704	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.667
ADCY1	PRKACA	ENSSBOP00000033334	ENSSBOP00000023352	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.925
ADCY1	PRKACB	ENSSBOP00000033334	ENSSBOP00000033118	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.929
ADCY2	ADCY1	ENSSBOP00000018241	ENSSBOP00000033334	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.479
ADCY2	ADCY4	ENSSBOP00000018241	ENSSBOP00000038607	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.439
ADCY2	ADCY5	ENSSBOP00000018241	ENSSBOP00000019426	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.786
ADCY2	ADCY6	ENSSBOP00000018241	ENSSBOP00000022198	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.778
ADCY2	ADCY7	ENSSBOP00000018241	ENSSBOP00000027520	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.439