STRINGSTRING
MAP2K6 MAP2K6 NFKBIE NFKBIE CD3G CD3G PSMC3 PSMC3 CASP9 CASP9 CD19 CD19 ENSSBOP00000002330 ENSSBOP00000002330 TRAF3 TRAF3 ENSSBOP00000002592 ENSSBOP00000002592 SHFM1 SHFM1 MDM2 MDM2 ENSSBOP00000003365 ENSSBOP00000003365 CXCL10 CXCL10 HLA-DRA HLA-DRA IRAK1 IRAK1 CALR CALR CDKN1A CDKN1A RUNX3 RUNX3 HLA-E HLA-E MAPK9 MAPK9 ENSSBOP00000005904 ENSSBOP00000005904 SAP30L SAP30L VIM VIM TAB1 TAB1 PIK3CA PIK3CA IRF9 IRF9 AKT1 AKT1 STAT2 STAT2 HLA-DMA HLA-DMA TNF TNF PSMC2 PSMC2 CD44 CD44 PIK3CB PIK3CB ENTPD1 ENTPD1 MAPK12 MAPK12 TAP2 TAP2 ENSSBOP00000008645 ENSSBOP00000008645 CCND3 CCND3 IFNAR1 IFNAR1 CD40 CD40 STAT1 STAT1 ENTPD3 ENTPD3 CCND2 CCND2 PSMC6 PSMC6 NEDD4 NEDD4 ENSSBOP00000011077 ENSSBOP00000011077 CASP3 CASP3 NFKBIA NFKBIA IKBKE IKBKE IKBKB IKBKB FCER2 FCER2 HLA-DOA HLA-DOA CDKN1B CDKN1B ICAM1 ICAM1 ISG15 ISG15 ENSSBOP00000013203 ENSSBOP00000013203 PSMC1 PSMC1 PSMD14 PSMD14 PSMD2 PSMD2 IL6 IL6 ENSSBOP00000014539 ENSSBOP00000014539 CHUK CHUK PSMD1 PSMD1 ENSSBOP00000015354 ENSSBOP00000015354 RBPJ RBPJ JAK1 JAK1 CCNA1 CCNA1 RAC1 RAC1 PIK3R3 PIK3R3 SNW1 SNW1 BID BID CD3D CD3D OAS3 OAS3 HDAC1 HDAC1 MYC MYC ENTPD8 ENTPD8 HDAC2 HDAC2 CD247 CD247 HLA-DPA1 HLA-DPA1 ADRM1 ADRM1 GADD45G GADD45G PLCG2 PLCG2 EIF2AK2 EIF2AK2 RBPJL RBPJL GADD45A GADD45A NCOR2 NCOR2 PSMD3 PSMD3 TRAF5 TRAF5 TAP1 TAP1 NFKB2 NFKB2 SIN3A SIN3A CASP8 CASP8 SYK SYK BCL2L11 BCL2L11 LYN LYN NFKB1 NFKB1 RB1 RB1 PSMD11 PSMD11 MAPK14 MAPK14 CCNE2 CCNE2 HES1 HES1 CCNE1 CCNE1 B2M B2M TRAF2 TRAF2 ENSSBOP00000024008 ENSSBOP00000024008 TRAF6 TRAF6 CIR1 CIR1 SAP30 SAP30 MAVS MAVS E2F1 E2F1 ENSSBOP00000025141 ENSSBOP00000025141 TBK1 TBK1 RIPK1 RIPK1 MAPK10 MAPK10 AKT3 AKT3 ITGAL ITGAL PDIA3 PDIA3 JAK3 JAK3 DDX58 DDX58 DDB2 DDB2 TRADD TRADD ENSSBOP00000029189 ENSSBOP00000029189 USP7 USP7 TAB2 TAB2 TAPBP TAPBP OAS2 OAS2 CCND1 CCND1 ENSSBOP00000030955 ENSSBOP00000030955 PSMD7 PSMD7 E2F3 E2F3 APAF1 APAF1 CD3E CD3E ENSSBOP00000032248 ENSSBOP00000032248 RELB RELB CCNA2 CCNA2 CD58 CD58 MAP3K7 MAP3K7 E2F2 E2F2 IKBKG IKBKG ENSSBOP00000034569 ENSSBOP00000034569 FAS FAS BLNK BLNK IRF3 IRF3 MAP2K4 MAP2K4 MAP3K14 MAP3K14 ENSSBOP00000035889 ENSSBOP00000035889 PIK3R2 PIK3R2 PSMC4 PSMC4 IRAK4 IRAK4 PSMC5 PSMC5 MAPK13 MAPK13 POLK POLK MAPK8 MAPK8 MAPK11 MAPK11 CDK6 CDK6 STAT3 STAT3 MAP2K3 MAP2K3 CDK4 CDK4 ENSSBOP00000038533 ENSSBOP00000038533 IRF7 IRF7 AKT2 AKT2 RELA RELA PIK3R1 PIK3R1 TNFAIP3 TNFAIP3 OAS1 OAS1 PSMD8 PSMD8 MYD88 MYD88 ENSSBOP00000040573 ENSSBOP00000040573
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (359 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
CD3GCD3g molecule. (181 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (401 aa)
CD19CD19 molecule. (559 aa)
ENSSBOP00000002330Ig-like domain-containing protein. (250 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa)
ENSSBOP00000002592Ig-like domain-containing protein. (184 aa)
SHFM1Uncharacterized protein. (70 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
ENSSBOP00000003365Ig-like domain-containing protein. (272 aa)
CXCL10C-X-C motif chemokine. (97 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (652 aa)
CALRCalreticulin. (417 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (158 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (346 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSBOP00000005904F-box domain-containing protein. (424 aa)
SAP30LSAP30 like. (182 aa)
VIMVimentin; Belongs to the intermediate filament family. (537 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IRF9Interferon regulatory factor 9. (394 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
STAT2Signal transducer and activator of transcription. (764 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (260 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (472 aa)
CD44CD44 molecule (Indian blood group). (727 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1091 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (525 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
TAP2Uncharacterized protein. (636 aa)
ENSSBOP00000008645Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (552 aa)
CD40CD40 molecule. (273 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (533 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (364 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
ENSSBOP00000011077Ig-like domain-containing protein; Belongs to the MHC class I family. (237 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
NFKBIANFKB inhibitor alpha. (310 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (750 aa)
FCER2Fc fragment of IgE receptor II. (324 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ICAM1Intercellular adhesion molecule 1. (535 aa)
ISG15ISG15 ubiquitin like modifier. (172 aa)
ENSSBOP00000013203Ig-like domain-containing protein. (257 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (448 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (808 aa)
IL6Interleukin 6. (213 aa)
ENSSBOP00000014539Ig-like domain-containing protein; Belongs to the MHC class I family. (405 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (949 aa)
ENSSBOP00000015354Ig-like domain-containing protein. (137 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (530 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (448 aa)
RAC1Uncharacterized protein. (207 aa)
PIK3R3Uncharacterized protein. (461 aa)
SNW1SKIP_SNW domain-containing protein. (571 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
CD3DCD3d molecule. (171 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MYCMYC proto-oncogene, bHLH transcription factor. (520 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (494 aa)
HDAC2Hist_deacetyl domain-containing protein. (314 aa)
CD247CD247 molecule. (165 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ADRM1Adhesion regulating molecule 1. (407 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (552 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (528 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
NCOR2Nuclear receptor corepressor 2. (2508 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (748 aa)
NFKB2Nuclear factor kappa B subunit 2. (877 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (494 aa)
SYKNon-specific protein-tyrosine kinase. (566 aa)
BCL2L11BCL2 like 11. (200 aa)
LYNTyrosine-protein kinase. (512 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RB1RB transcriptional corepressor 1. (926 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (406 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (122 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (526 aa)
ENSSBOP00000024008Ig-like domain-containing protein. (263 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (537 aa)
CIR1Corepressor interacting with RBPJ, 1. (437 aa)
SAP30Sin3A associated protein 30. (124 aa)
MAVSMitochondrial antiviral signaling protein. (533 aa)
E2F1E2F transcription factor 1. (352 aa)
ENSSBOP00000025141Ig-like domain-containing protein; Belongs to the MHC class I family. (271 aa)
TBK1TANK binding kinase 1. (729 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
MAPK10Mitogen-activated protein kinase. (541 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1170 aa)
PDIA3Protein disulfide isomerase family A member 3; Belongs to the protein disulfide isomerase family. (424 aa)
JAK3Tyrosine-protein kinase. (1149 aa)
DDX58DExD/H-box helicase 58. (937 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
TRADDTNFRSF1A associated via death domain. (252 aa)
ENSSBOP00000029189Ig-like domain-containing protein. (288 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1112 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAPBPTAP binding protein. (511 aa)
OAS22'-5'-oligoadenylate synthetase 2. (719 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSSBOP00000030955Ig-like domain-containing protein. (235 aa)
PSMD7MPN domain-containing protein. (324 aa)
E2F3E2F transcription factor 3. (427 aa)
APAF1Apoptotic peptidase activating factor 1. (1193 aa)
CD3ECD3e molecule. (198 aa)
ENSSBOP00000032248Ig-like domain-containing protein. (298 aa)
RELBRELB proto-oncogene, NF-kB subunit. (579 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CD58CD58 molecule. (258 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
E2F2E2F transcription factor 2. (437 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (440 aa)
ENSSBOP00000034569Uncharacterized protein. (186 aa)
FASFas cell surface death receptor. (327 aa)
BLNKB cell linker. (456 aa)
IRF3Interferon regulatory factor 3. (427 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (406 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (965 aa)
ENSSBOP00000035889Ig-like domain-containing protein. (275 aa)
PIK3R2Uncharacterized protein. (674 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (416 aa)
MAPK13Mitogen-activated protein kinase. (450 aa)
POLKDNA polymerase kappa. (863 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK11Mitogen-activated protein kinase. (372 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
STAT3Signal transducer and activator of transcription. (721 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (354 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
ENSSBOP00000038533Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
IRF7Interferon regulatory factor 7. (479 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RELARELA proto-oncogene, NF-kB subunit. (520 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (727 aa)
TNFAIP3TNF alpha induced protein 3. (791 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
ENSSBOP00000040573Ig-like domain-containing protein; Belongs to the MHC class I family. (411 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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