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Ccel_0360 Ccel_0360 groS groS groL groL Ccel_0492 Ccel_0492 Ccel_0583 Ccel_0583 Ccel_0584 Ccel_0584 Ccel_0585 Ccel_0585 Ccel_0690 Ccel_0690 clpP clpP clpX clpX Ccel_0950 Ccel_0950 Ccel_1017 Ccel_1017 Ccel_1067 Ccel_1067 Ccel_1144 Ccel_1144 Ccel_1402 Ccel_1402 Ccel_1497 Ccel_1497 Ccel_1779 Ccel_1779 dnaJ dnaJ dnaK dnaK grpE grpE hrcA hrcA Ccel_2116 Ccel_2116 Ccel_2211 Ccel_2211 lon lon Ccel_2938 Ccel_2938
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Ccel_0360PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: cth:Cthe_1945 thioredoxin-disulfide reductase. (291 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (94 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (543 aa)
Ccel_0492PFAM: heat shock protein Hsp90; ATP-binding region ATPase domain protein; KEGG: cth:Cthe_0550 heat shock protein 90. (634 aa)
Ccel_0583PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: cbe:Cbei_2144 ABC transporter related. (583 aa)
Ccel_0584PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: cbe:Cbei_2145 ABC transporter related. (582 aa)
Ccel_0585KEGG: fma:FMG_1340 hypothetical protein. (262 aa)
Ccel_0690Manganese and iron superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
clpPATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (194 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (431 aa)
Ccel_0950HI0933 family protein; PFAM: glucose-inhibited division protein A; HI0933 family protein; FAD dependent oxidoreductase; KEGG: tbd:Tbd_1475 hypothetical protein. (435 aa)
Ccel_1017Cytochrome c biogenesis protein-like protein; KEGG: cpy:Cphy_2189 glutaredoxin 2. (519 aa)
Ccel_1067TIGRFAM: redox-active disulfide protein 2; KEGG: dsy:DSY4674 hypothetical protein. (100 aa)
Ccel_1144PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA family protein; Rhodanese domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: afl:Aflv_0303 multidomain redox protein (NAD(FAD)-dependent oxidoreductase; rhodanese domain; SirA-like redox domain; peroxiredoxin domain); Belongs to the sulfur carrier protein TusA family. (817 aa)
Ccel_1402Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (173 aa)
Ccel_1497KEGG: bsu:BSU39290 hypothetical protein. (144 aa)
Ccel_1779TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein; KEGG: tex:Teth514_0924 thioredoxin reductase. (308 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (379 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (616 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (197 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (348 aa)
Ccel_2116PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_0312 ATPase AAA-2; Belongs to the ClpA/ClpB family. (781 aa)
Ccel_2211TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: cth:Cthe_0360 thioredoxin; Belongs to the thioredoxin family. (108 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (779 aa)
Ccel_2938PFAM: heat shock protein Hsp20; KEGG: cbe:Cbei_4123 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (145 aa)
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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