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| | Ccel_0016 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: cpy:Cphy_3558 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (1183 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: cth:Cthe_2260 prephenate dehydratase. (280 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (310 aa) |
| | Ccel_0138 | PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: cth:Cthe_0344 malate dehydrogenase. (391 aa) |
| | Ccel_0175 | PFAM: metalloenzyme domain protein; KEGG: cth:Cthe_2087 metalloenzyme. (297 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (597 aa) |
| | Ccel_0259 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; KEGG: cth:Cthe_2597 ribose-5-phosphate isomerase. (149 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | Ccel_0303 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: cth:Cthe_2714 acetolactate synthase, large subunit. (559 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa) |
| | hisZ | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (419 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: cth:Cthe_2883 histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (236 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. (211 aa) |
| | Ccel_0425 | PFAM: aminotransferase class V; Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: cth:Cthe_1918 arginine decarboxylase. (488 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (284 aa) |
| | Ccel_0524 | PFAM: amino acid-binding ACT domain protein; KEGG: csc:Csac_1581 amino acid-binding ACT domain-containing protein. (156 aa) |
| | dapB-2 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | Ccel_0528 | TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: cth:Cthe_1375 aspartate kinase; Belongs to the aspartokinase family. (454 aa) |
| | Ccel_0551 | KEGG: cth:Cthe_0869 hypothetical protein. (226 aa) |
| | Ccel_0553 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cth:Cthe_0867 2-oxoglutarate ferredoxin oxidoreductase, delta subunit. (68 aa) |
| | Ccel_0554 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: cth:Cthe_0866 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (352 aa) |
| | Ccel_0555 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: cth:Cthe_0865 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). (248 aa) |
| | Ccel_0556 | PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: cth:Cthe_0864 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (177 aa) |
| | Ccel_0659 | PFAM: GCN5-related N-acetyltransferase; KEGG: cbf:CLI_3229 acetyltransferase. (172 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (294 aa) |
| | Ccel_0700 | PFAM: ROK family protein; KEGG: cth:Cthe_2938 glucokinase. (325 aa) |
| | Ccel_0932 | PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: mja:MJ1229 pyruvate carboxylase subunit A. (513 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa) |
| | Ccel_1039 | PFAM: Pyridoxal-dependent decarboxylase; KEGG: mst:Msp_0329 MfnA. (412 aa) |
| | Ccel_1042 | PFAM: aminotransferase class I and II; KEGG: cdf:CD1549 putative histidinol-phosphate aminotransferase. (362 aa) |
| | Ccel_1084 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. (240 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (639 aa) |
| | Ccel_1128 | PFAM: Saccharopine dehydrogenase; KEGG: cbe:Cbei_4409 saccharopine dehydrogenase. (399 aa) |
| | Ccel_1129 | TIGRFAM: carboxynorspermidine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: dsy:DSY3820 hypothetical protein. (382 aa) |
| | Ccel_1164 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: cdf:CD2682 pyruvate-flavodoxin oxidoreductase. (1176 aa) |
| | Ccel_1179 | TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I; KEGG: cno:NT01CX_1588 mannose-6-phosphate isomerase, class I. (349 aa) |
| | Ccel_1188 | PFAM: aminotransferase class V; KEGG: csc:Csac_1303 aminotransferase, class V. (383 aa) |
| | Ccel_1189 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: csc:Csac_1304 D-3-phosphoglycerate dehydrogenase. (535 aa) |
| | Ccel_1264 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: amt:Amet_0502 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (575 aa) |
| | Ccel_1265 | PFAM: dihydrodipicolinate synthetase; KEGG: cdf:CD3000 putative dihydrodipicolinate synthase; Belongs to the DapA family. (297 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: cth:Cthe_0178 argininosuccinate lyase. (459 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: cth:Cthe_0179 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (404 aa) |
| | Ccel_1417 | PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; KEGG: cth:Cthe_1265 alpha-phosphoglucomutase. (576 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: cth:Cthe_0217 glucose-6-phosphate isomerase; Belongs to the GPI family. (450 aa) |
| | Ccel_1450 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cth:Cthe_1381 threonine synthase. (507 aa) |
| | Ccel_1451 | PFAM: amino acid-binding ACT domain protein; KEGG: cth:Cthe_1377 hypothetical protein; Belongs to the UPF0735 family. (146 aa) |
| | Ccel_1452 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cth:Cthe_1376 homoserine dehydrogenase. (414 aa) |
| | Ccel_1537 | PFAM: ribulose-phosphate 3-epimerase; KEGG: cth:Cthe_0576 ribulose-5-phosphate 3-epimerase. (222 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | Ccel_1612 | PFAM: aminotransferase class-III; KEGG: reu:Reut_A2723 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein. (405 aa) |
| | Ccel_1618 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: Chorismate mutase; DAHP synthetase I/KDSA; KEGG: lin:lin1641 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (350 aa) |
| | Ccel_1621 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: hhe:HH1135 3-isopropylmalate dehydratase; Belongs to the LeuD family. (166 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | Ccel_1624 | PFAM: pyruvate carboxyltransferase; KEGG: mth:MTH1630 trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa) |
| | Ccel_1640 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; KEGG: msu:MS0383 RpiB protein. (152 aa) |
| | Ccel_1721 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: cdf:CD0487 putative carbon-nitrogen hydrolase. (267 aa) |
| | Ccel_1730 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (120 aa) |
| | Ccel_1736 | Conserved carboxylase region; PFAM: pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: cth:Cthe_0701 oxaloacetate decarboxylase. (510 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | Ccel_1802 | PFAM: aminotransferase class IV; KEGG: cno:NT01CX_1857 branched-chain amino acid aminotransferase, putative. (279 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (189 aa) |
| | Ccel_1877 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: cth:Cthe_0856 branched chain amino acid aminotransferase. (356 aa) |
| | Ccel_1965 | PFAM: aminotransferase class I and II; KEGG: cno:NT01CX_0284 aspartate aminotransferase. (393 aa) |
| | Ccel_2071 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: cth:Cthe_0880 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (337 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (400 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | Ccel_2137 | TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: cth:Cthe_1029 phosphotransacetylase. (331 aa) |
| | Ccel_2140 | Proposed homoserine kinase; TIGRFAM: phosphonopyruvate decarboxylase-related protein; proposed homoserine kinase; PFAM: metalloenzyme domain protein; Homoserine kinase family protein; KEGG: cth:Cthe_1292 phosphoglycerate mutase. (403 aa) |
| | Ccel_2176 | TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein; KEGG: cth:Cthe_3158 aconitate hydratase. (642 aa) |
| | Ccel_2177 | PFAM: pyruvate carboxyltransferase; KEGG: cth:Cthe_3157 pyruvate carboxyltransferase. (457 aa) |
| | Ccel_2222 | TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; KEGG: cth:Cthe_0349 fructose-bisphosphate aldolase. (311 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (415 aa) |
| | Ccel_2224 | TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL; KEGG: drm:Dred_0039 formate acetyltransferase. (742 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | tpiA | Phosphoglycerate kinase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (646 aa) |
| | Ccel_2275 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: cth:Cthe_0137 glyceraldehyde-3-phosphate dehydrogenase. (335 aa) |
| | Ccel_2373 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: hya:HY04AAS1_1586 predicted phospho-2-dehydro-3-deoxyheptonate aldolase. (267 aa) |
| | Ccel_2374 | PFAM: 3-dehydroquinate synthase; KEGG: hmo:HM1_1788 3-dehydroquinate synthase, putative. (387 aa) |
| | Ccel_2421 | TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region; KEGG: cth:Cthe_3091 tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit. (185 aa) |
| | Ccel_2422 | TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; KEGG: cth:Cthe_3090 fumarate hydratase. (280 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (392 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (422 aa) |
| | Ccel_2430 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: cth:Cthe_0374 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | Ccel_2434 | TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: amt:Amet_2650 putative agmatinase; Belongs to the arginase family. (287 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | ldh-2 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa) |
| | Ccel_2511 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: aeh:Mlg_0126 Orn/DAP/Arg decarboxylase 2. (416 aa) |
| | Ccel_2533 | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (329 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | Ccel_2567 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bcy:Bcer98_0765 tartrate dehydrogenase. (356 aa) |
| | Ccel_2569 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein mobile region; Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: csc:Csac_1831 pyruvate kinase; Belongs to the pyruvate kinase family. (580 aa) |
| | Ccel_2571 | PFAM: Citrate synthase; KEGG: mta:Moth_1122 methylcitrate synthase; Belongs to the citrate synthase family. (450 aa) |
| | Ccel_2576 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: ckl:CKL_0546 isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (402 aa) |
| | Ccel_2581 | Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (240 aa) |
| | Ccel_2582 | TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL; KEGG: cth:Cthe_0505 formate acetyltransferase. (742 aa) |
| | Ccel_2591 | TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; KEGG: cpy:Cphy_0426 aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | Ccel_2880 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: cth:Cthe_1795 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (341 aa) |
| | Ccel_2881 | Prephenate dehydrogenase; PFAM: amino acid-binding ACT domain protein; Prephenate dehydrogenase; KEGG: cth:Cthe_1796 prephenate dehydrogenase. (366 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (313 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: cth:Cthe_1866 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | Ccel_3198 | PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: cdf:CD2966 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (867 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (488 aa) |
| | Ccel_3214 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: rsd:TGRD_117 anthranilate synthase glutamine amidotransferase component. (193 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: rsd:TGRD_119 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: rsd:TGRD_120 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | Ccel_3221 | PFAM: hexokinase; KEGG: hmo:HM1_0763 hexokinase, putative. (431 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily. (311 aa) |
| | Ccel_3255 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: gme:Gmet_2019 Orn/DAP/Arg decarboxylase 2. (415 aa) |
| | arcA | PFAM: amidinotransferase; KEGG: amt:Amet_3161 arginine deiminase. (410 aa) |
| | Ccel_3415 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | Ccel_3433 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: cth:Cthe_2519 alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (520 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (508 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | Ccel_3436 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit; KEGG: cth:Cthe_2517 acetolactate synthase, small subunit. (169 aa) |
| | Ccel_3437 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: cth:Cthe_2516 acetolactate synthase, large subunit. (542 aa) |
