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Ccel_0016 Ccel_0016 leuC leuC leuD leuD leuB leuB ldh ldh Ccel_0138 Ccel_0138 pckG pckG ilvD ilvD Ccel_0303 Ccel_0303 Ccel_0551 Ccel_0551 Ccel_0553 Ccel_0553 Ccel_0554 Ccel_0554 Ccel_0555 Ccel_0555 Ccel_0556 Ccel_0556 Ccel_0932 Ccel_0932 Ccel_1164 Ccel_1164 Ccel_1264 Ccel_1264 Ccel_1621 Ccel_1621 leuC-2 leuC-2 Ccel_1624 Ccel_1624 Ccel_1721 Ccel_1721 Ccel_1736 Ccel_1736 Ccel_1802 Ccel_1802 Ccel_1877 Ccel_1877 ackA ackA Ccel_2137 Ccel_2137 Ccel_2176 Ccel_2176 Ccel_2177 Ccel_2177 Ccel_2224 Ccel_2224 Ccel_2421 Ccel_2421 Ccel_2422 Ccel_2422 Ccel_2430 Ccel_2430 ldh-2 ldh-2 Ccel_2567 Ccel_2567 Ccel_2571 Ccel_2571 Ccel_2576 Ccel_2576 Ccel_2581 Ccel_2581 Ccel_2582 Ccel_2582 Ccel_3198 Ccel_3198 Ccel_3433 Ccel_3433 leuA leuA ilvC ilvC Ccel_3436 Ccel_3436 Ccel_3437 Ccel_3437
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Ccel_0016PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: cpy:Cphy_3558 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (1183 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (310 aa)
Ccel_0138PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: cth:Cthe_0344 malate dehydrogenase. (391 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (597 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
Ccel_0303TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: cth:Cthe_2714 acetolactate synthase, large subunit. (559 aa)
Ccel_0551KEGG: cth:Cthe_0869 hypothetical protein. (226 aa)
Ccel_0553PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cth:Cthe_0867 2-oxoglutarate ferredoxin oxidoreductase, delta subunit. (68 aa)
Ccel_0554PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: cth:Cthe_0866 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (352 aa)
Ccel_0555PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: cth:Cthe_0865 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). (248 aa)
Ccel_0556PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: cth:Cthe_0864 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (177 aa)
Ccel_0932PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: mja:MJ1229 pyruvate carboxylase subunit A. (513 aa)
Ccel_1164PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: cdf:CD2682 pyruvate-flavodoxin oxidoreductase. (1176 aa)
Ccel_1264PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: amt:Amet_0502 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (575 aa)
Ccel_1621TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: hhe:HH1135 3-isopropylmalate dehydratase; Belongs to the LeuD family. (166 aa)
leuC-2Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
Ccel_1624PFAM: pyruvate carboxyltransferase; KEGG: mth:MTH1630 trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa)
Ccel_1721PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: cdf:CD0487 putative carbon-nitrogen hydrolase. (267 aa)
Ccel_1736Conserved carboxylase region; PFAM: pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: cth:Cthe_0701 oxaloacetate decarboxylase. (510 aa)
Ccel_1802PFAM: aminotransferase class IV; KEGG: cno:NT01CX_1857 branched-chain amino acid aminotransferase, putative. (279 aa)
Ccel_1877TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: cth:Cthe_0856 branched chain amino acid aminotransferase. (356 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
Ccel_2137TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: cth:Cthe_1029 phosphotransacetylase. (331 aa)
Ccel_2176TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein; KEGG: cth:Cthe_3158 aconitate hydratase. (642 aa)
Ccel_2177PFAM: pyruvate carboxyltransferase; KEGG: cth:Cthe_3157 pyruvate carboxyltransferase. (457 aa)
Ccel_2224TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL; KEGG: drm:Dred_0039 formate acetyltransferase. (742 aa)
Ccel_2421TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region; KEGG: cth:Cthe_3091 tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit. (185 aa)
Ccel_2422TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; KEGG: cth:Cthe_3090 fumarate hydratase. (280 aa)
Ccel_2430PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: cth:Cthe_0374 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
Ccel_2567TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bcy:Bcer98_0765 tartrate dehydrogenase. (356 aa)
Ccel_2571PFAM: Citrate synthase; KEGG: mta:Moth_1122 methylcitrate synthase; Belongs to the citrate synthase family. (450 aa)
Ccel_2576TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: ckl:CKL_0546 isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (402 aa)
Ccel_2581Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (240 aa)
Ccel_2582TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL; KEGG: cth:Cthe_0505 formate acetyltransferase. (742 aa)
Ccel_3198PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: cdf:CD2966 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (867 aa)
Ccel_3433TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: cth:Cthe_2519 alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (520 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (508 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
Ccel_3436TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit; KEGG: cth:Cthe_2517 acetolactate synthase, small subunit. (169 aa)
Ccel_3437TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: cth:Cthe_2516 acetolactate synthase, large subunit. (542 aa)
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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