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| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | sigI | RNA polymerase, sigma 28 subunit, SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; Belongs to the sigma-70 factor family. SigI subfamily. (252 aa) |
| | Ccel_1738 | PFAM: carboxyl transferase; KEGG: cth:Cthe_0699 carboxyl transferase. (516 aa) |
| | cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: cth:Cthe_0712 cytidylate kinase. (223 aa) |
| | Ccel_1723 | PFAM: amino acid-binding ACT domain protein; KEGG: cth:Cthe_0409 hypothetical protein; Belongs to the UPF0237 family. (89 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (392 aa) |
| | Ccel_1636 | KEGG: cth:Cthe_1362 NusG antitermination factor. (85 aa) |
| | Ccel_1610 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: paa:Paes_1634 nitrogenase cofactor biosynthesis protein NifB. (269 aa) |
| | Ccel_1606 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (402 aa) |
| | Ccel_1605 | TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: nth:Nther_1267 molybdopterin-guanine dinucleotide biosynthesis protein B. (168 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (328 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | Ccel_1601 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: dau:Daud_1891 molybdenum cofactor synthesis domain-containing protein. (161 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (188 aa) |
| | Ccel_1538 | TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: cth:Cthe_0577 thiamine pyrophosphokinase. (211 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (818 aa) |
| | Ccel_1460 | PFAM: tryptophan RNA-binding attenuator protein; KEGG: cth:Cthe_1263 transcription attenuation protein MtrB. (77 aa) |
| | Ccel_1459 | DNA polymerase III, alpha subunit; KEGG: cth:Cthe_1264 DNA polymerase III DnaE; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1159 aa) |
| | Ccel_1447 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: cth:Cthe_1384 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (424 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | Ccel_1364 | KEGG: ctc:CTC02054 metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. (190 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (204 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (171 aa) |
| | Ccel_1333 | PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; KEGG: tte:TTE0370 ATP:corrinoid adenosyltransferase. (177 aa) |
| | Ccel_1332 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: cno:NT01CX_0374 bifunctional folate synthesis protein. (157 aa) |
| | Ccel_1331 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | Ccel_1330 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (274 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: cbb:CLD_2996 GTP cyclohydrolase I. (195 aa) |
| | Ccel_1327 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cth:Cthe_0166 4Fe-4S ferredoxin, iron-sulfur binding. (227 aa) |
| | dinB | UMUC domain protein DNA-repair protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (399 aa) |
| | Ccel_1310 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (320 aa) |
| | Ccel_1285 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: cpy:Cphy_1382 precorrin-8X methylmutase CbiC/CobH. (211 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (514 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa) |
| | Ccel_1282 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: cpy:Cphy_1379 precorrin-6x reductase. (395 aa) |
| | Ccel_1281 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: ppd:Ppro_1299 cobalamin (vitamin B12) biosynthesis CbiX protein. (120 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: aoe:Clos_1330 glutamate-1-semialdehyde-2,1-aminomutase. (434 aa) |
| | Ccel_1279 | PFAM: delta-aminolevulinic acid dehydratase; KEGG: aoe:Clos_1329 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (325 aa) |
| | Ccel_3187 | PFAM: DNA/pantothenate metabolism flavoprotein domain protein; KEGG: efa:EF2655 phosphopantothenate--cysteine ligase. (264 aa) |
| | Ccel_3183 | TIGRFAM: seryl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Seryl-tRNA synthetase, class IIa-like; KEGG: cbe:Cbei_1431 seryl-tRNA synthetase. (425 aa) |
| | Ccel_3161 | PFAM: zinc finger CHC2-family protein; KEGG: aoe:Clos_1919 zinc finger CHC2-family protein. (340 aa) |
| | Ccel_3104 | PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; KEGG: cbe:Cbei_4439 thiamine biosynthesis protein ThiH. (470 aa) |
| | Ccel_3093 | UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (390 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | Ccel_3478 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; KEGG: cth:Cthe_2354 nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family. (278 aa) |
| | Ccel_3450 | PFAM: dehydrogenase E1 component; KEGG: tpd:Teth39_0790 pyruvate dehydrogenase (acetyl-transferring). (321 aa) |
| | murA-2 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (690 aa) |
| | Ccel_3319 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-H factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: cth:Cthe_2059 RNA polymerase factor sigma-70. (214 aa) |
| | Ccel_3259 | PFAM: aminotransferase class-III; KEGG: bca:BCE_4189 adenosylmethionine--8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (436 aa) |
| | Ccel_3257 | KEGG: saq:Sare_0485 hypothetical protein. (437 aa) |
| | Ccel_3227 | PFAM: RelA/SpoT domain protein; KEGG: cbe:Cbei_2333 RelA/SpoT domain protein. (230 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: rsd:TGRD_120 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: rsd:TGRD_119 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (488 aa) |
| | Ccel_3189 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: cpy:Cphy_2083 biotin synthase. (345 aa) |
| | Ccel_3188 | PFAM: flavoprotein; KEGG: efa:EF2656 phosphopantothenoylcysteine decarboxylase. (178 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | Ccel_3062 | PFAM: DNA-directed DNA polymerase; KEGG: drm:Dred_1191 DNA-directed DNA polymerase. (652 aa) |
| | Ccel_3006 | PFAM: cobalamin synthesis protein P47K; KEGG: cbe:Cbei_2463 cobalamin synthesis protein, P47K. (310 aa) |
| | Ccel_2987 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (479 aa) |
| | carB-2 | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: cth:Cthe_1868 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1070 aa) |
| | carA-2 | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: cth:Cthe_1867 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (351 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | Ccel_2862 | Putative RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; KEGG: ckl:CKL_2666 hypothetical protein. (177 aa) |
| | Ccel_2856 | PFAM: DNA-directed DNA polymerase; KEGG: bca:BCE_0377 DNA polymerase I. (647 aa) |
| | Ccel_2851 | KEGG: bca:BCE_0383 hypothetical protein. (144 aa) |
| | Ccel_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | Ccel_0082 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (446 aa) |
| | Ccel_0084 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (255 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (206 aa) |
| | Ccel_0159 | KEGG: cth:Cthe_2105 DNA polymerase III, delta prime subunit. (322 aa) |
| | Ccel_0177 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (167 aa) |
| | Ccel_0204 | NusG antitermination factor; PFAM: NGN domain protein; KEGG: cth:Cthe_1362 NusG antitermination factor. (188 aa) |
| | Ccel_0211 | ATPase; KEGG: cbt:CLH_3263 ATPase. (366 aa) |
| | Ccel_0228 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: csc:Csac_0467 ECF subfamily RNA polymerase sigma-24 factor. (180 aa) |
| | Ccel_0233 | TIGRFAM: C_GCAxxG_C_C family protein; KEGG: cth:Cthe_1399 C_GCAxxG_C_C family protein. (156 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (562 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (235 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (76 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (161 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (175 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (505 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (465 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (172 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1246 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1169 aa) |
| | Ccel_0366 | TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit; KEGG: swo:Swol_1124 hypothetical protein. (304 aa) |
| | Ccel_0375 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: dsy:DSY4418 hypothetical protein. (189 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: cth:Cthe_2885 phosphoribosylaminoimidazole-succinocarboxamide synthase. (298 aa) |
| | Ccel_0394 | PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. (500 aa) |
| | Ccel_0400 | TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG: cth:Cthe_2900 RNA polymerase, sigma 28 subunit. (249 aa) |
| | Ccel_0414 | PFAM: phosphoribosyltransferase; KEGG: ypg:YpAngola_A4140 putative phosphoribosyl transferase protein. (187 aa) |
| | Ccel_0417 | PFAM: cellulosome protein dockerin type I; KEGG: cth:Cthe_0246 carbohydrate-binding family 6 protein. (848 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | polC | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1433 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (382 aa) |
| | Ccel_0461 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: cth:Cthe_0987 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (311 aa) |
| | Ccel_0499 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; KEGG: cth:Cthe_0554 phosphoribosylformylglycinamidine synthase. (1256 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (340 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (373 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (604 aa) |
| | sigA | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (359 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | pyrR | Phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: cth:Cthe_0953 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: cth:Cthe_0951 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (312 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: cth:Cthe_0950 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (360 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: cth:Cthe_0949 carbamoyl phosphate synthase large subunit; Belongs to the CarB family. (1071 aa) |
| | pyrK | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (307 aa) |
| | Ccel_0620 | KEGG: cth:Cthe_0784 hypothetical protein. (285 aa) |
| | Ccel_0632 | KEGG: cts:Ctha_2703 hypothetical protein. (115 aa) |
| | Ccel_0634 | KEGG: ckl:CKL_2293 hypothetical protein. (176 aa) |
| | Ccel_0644 | PFAM: cobalbumin biosynthesis protein; SMART: AAA ATPase; KEGG: tte:TTE0381 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase. (190 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (250 aa) |
| | cobT | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (352 aa) |
| | cinA | Competence/damage-inducible protein CinA; TIGRFAM: molybdenum cofactor synthesis domain protein; competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; KEGG: cth:Cthe_1052 competence/damage-inducible protein CinA. (415 aa) |
| | Ccel_0705 | KEGG: pdi:BDI_2301 pantothenate kinase. (281 aa) |
| | Ccel_0723 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: cth:Cthe_0741 adenylosuccinate lyase. (475 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (315 aa) |
| | Ccel_0803 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: cth:Cthe_2731 ECF subfamily RNA polymerase sigma-24 factor. (184 aa) |
| | Ccel_0849 | NusG antitermination factor; PFAM: NGN domain protein; KEGG: cth:Cthe_1362 NusG antitermination factor. (173 aa) |
| | Ccel_0873 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: sez:Sez_1209 oxygen-independent coproporphyrinogen III oxidase 1. (443 aa) |
| | Ccel_0927 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: lsp:Bsph_1728 RNA polymerase sigma factor SigX; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | Ccel_0932 | PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: mja:MJ1229 pyruvate carboxylase subunit A. (513 aa) |
| | Ccel_0934 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (458 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (260 aa) |
| | Ccel_1043 | PFAM: Haloacid dehalogenase domain protein hydrolase type 3; KEGG: cth:Cthe_1482 Cof-like hydrolase. (292 aa) |
| | Ccel_1081 | PFAM: purine or other phosphorylase family 1; KEGG: cbt:CLH_3244 uridine phosphorylase. (252 aa) |
| | Ccel_1084 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; KEGG: cbt:CLH_3241 tryptophan synthase, alpha subunit. (240 aa) |
| | Ccel_1120 | PFAM: FRG domain protein; KEGG: hne:HNE_3339 hypothetical protein. (238 aa) |
| | Ccel_1182 | PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: cth:Cthe_1803 cobalamin (vitamin B12) biosynthesis CbiM protein. (331 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (642 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (309 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (248 aa) |
| | cbiN | Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (97 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (384 aa) |
| | Ccel_1271 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: cpy:Cphy_1375 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (226 aa) |
| | Ccel_1272 | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: cpy:Cphy_1376 precorrin-4 C11-methyltransferase. (251 aa) |
| | Ccel_1273 | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: cpy:Cphy_1377 cobalamin (vitamin B12) biosynthesis CbiG protein. (340 aa) |
| | hemA | Tetrapyrrole biosynthesis, glutamyl-tRNA reductase-like protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (336 aa) |
| | Ccel_1275 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: cpy:Cphy_1378 precorrin-3B C17-methyltransferase. (244 aa) |
| | Ccel_1276 | TIGRFAM: precorrin-6x reductase; siroheme synthase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: aoe:Clos_1326 precorrin-6X reductase. (407 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (293 aa) |
| | Ccel_1278 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: cth:Cthe_2528 uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase. (504 aa) |
| | Ccel_2846 | Putative RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; KEGG: ckl:CKL_2654 hypothetical protein. (137 aa) |
| | Ccel_2809 | PFAM: GCN5-related N-acetyltransferase; protein of unknown function UPF0157; KEGG: ckl:CKL_2615 hypothetical protein. (406 aa) |
| | Ccel_2740 | KEGG: ckl:CKL_3863 hypothetical protein. (310 aa) |
| | Ccel_2734 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: efa:EF2290 ECF subfamily RNA polymerase sigma factor. (130 aa) |
| | Ccel_2635 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: cpy:Cphy_1094 ECF subfamily RNA polymerase sigma-24 factor. (170 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa) |
| | Ccel_2546 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: cth:Cthe_0373 ferredoxin--NADP(+) reductase subunit alpha. (281 aa) |
| | tmk-2 | Thymidylate kinase-like protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (230 aa) |
| | Ccel_2510 | PFAM: protein of unknown function DUF201; KEGG: saq:Sare_0485 hypothetical protein. (450 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (424 aa) |
| | Ccel_2401 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (795 aa) |
| | Ccel_2284 | RNA polymerase, sigma 28 subunit, SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (249 aa) |
| | Ccel_2207 | TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: csc:Csac_1293 Cof-like hydrolase. (273 aa) |
| | Ccel_2205 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: cth:Cthe_0368 NCAIR mutase (PurE)-related protein. (248 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (487 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: cth:Cthe_1248 phosphoribosylformylglycinamidine cyclo-ligase. (340 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa) |
| | purH | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: cth:Cthe_1246 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (514 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-grasp domain protein; KEGG: cth:Cthe_1245 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (419 aa) |
| | Ccel_2173 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: cdf:CD0677 putative RNA polymerase sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (160 aa) |
| | Ccel_2164 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: amt:Amet_4132 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (182 aa) |
| | Ccel_2137 | TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: cth:Cthe_1029 phosphotransacetylase. (331 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | Ccel_2077 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: cth:Cthe_0890 ECF subfamily RNA polymerase sigma-24 factor. (197 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (896 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa) |
| | Ccel_2070 | PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: cth:Cthe_0439 CobB/CobQ-like glutamine amidotransferase. (248 aa) |
| | Ccel_2069 | PFAM: Mur ligase middle domain protein; domain of unknown function DUF1727; KEGG: cth:Cthe_0440 hypothetical protein. (467 aa) |
| | Ccel_2062 | RNA polymerase, sigma 28 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (243 aa) |
| | Ccel_2061 | RNA polymerase, sigma 28 subunit, SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (257 aa) |
| | Ccel_2048 | ATPase FliI/YscN; KEGG: cth:Cthe_0468 flagellar protein export ATPase FliI; TIGRFAM: ATPase, FliI/YscN family; ATPase FliI/YscN; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; SMART: AAA ATPase. (437 aa) |
| | Ccel_2022 | TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: cth:Cthe_0495 RNA polymerase, sigma 28 subunit. (254 aa) |
| | Ccel_2015 | KEGG: cpy:Cphy_3137 hypothetical protein. (128 aa) |
| | dinB-2 | UMUC domain protein DNA-repair protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (413 aa) |
| | Ccel_2006 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | Ccel_2005 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: cth:Cthe_0105 riboflavin synthase subunit alpha. (218 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (420 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | Ccel_1992 | TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: cbf:CLI_0857 phosphomethylpyrimidine kinase. (270 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa) |
| | Ccel_1980 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (380 aa) |
| | Ccel_1966 | PFAM: 3-demethylubiquinone-9 3-methyltransferase; KEGG: bcl:ABC0853 hypothetical protein. (135 aa) |
| | Ccel_1954 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit. (339 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | Ccel_1951 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (726 aa) |
| | Ccel_1948 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: cth:Cthe_1341 coproporphyrinogen III oxidase. (504 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (145 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (623 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (286 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (189 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | Ccel_1851 | TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: cac:CAC2941 HAD family phosphatase. (274 aa) |
| | Ccel_1841 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; KEGG: hmo:HM1_0052 hypothetical protein. (230 aa) |
| | Ccel_1831 | PFAM: RelA/SpoT domain protein; KEGG: esi:Exig_1629 RelA/SpoT domain-containing protein. (198 aa) |
| | Ccel_1803 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: cth:Cthe_2359 metal dependent phosphohydrolase. (196 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (201 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (68 aa) |
