STRINGSTRING
murA murA ddl ddl Ccel_0371 Ccel_0371 murE murE murF murF mraY mraY murG murG Ccel_0487 Ccel_0487 Ccel_0520 Ccel_0520 murJ murJ Ccel_0711 Ccel_0711 Ccel_0965 Ccel_0965 Ccel_0982 Ccel_0982 uppP uppP Ccel_1370 Ccel_1370 mltG mltG Ccel_1555 Ccel_1555 Ccel_1558 Ccel_1558 murD murD Ccel_1749 Ccel_1749 Ccel_1807 Ccel_1807 Ccel_2018 Ccel_2018 Ccel_2069 Ccel_2069 Ccel_2070 Ccel_2070 murB murB Ccel_2390 Ccel_2390 Ccel_2514 Ccel_2514 Ccel_2590 Ccel_2590 Ccel_2610 Ccel_2610 Ccel_2876 Ccel_2876 amj amj Ccel_3093 Ccel_3093 murC murC Ccel_3207 Ccel_3207 Ccel_3348 Ccel_3348 murA-2 murA-2 murI murI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa)
ddlD-alanine/D-alanine ligase; Cell wall formation. (376 aa)
Ccel_0371PFAM: sulfatase; KEGG: cac:CAC2802 phosphoglycerol transferase. (625 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (486 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (459 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (327 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (364 aa)
Ccel_0487PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: cth:Cthe_3179 serine-type D-Ala-D-Ala carboxypeptidase. (401 aa)
Ccel_0520PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: cth:Cthe_1171 serine-type D-Ala-D-Ala carboxypeptidase. (406 aa)
murJIntegral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (549 aa)
Ccel_0711KEGG: cth:Cthe_0768 nucleic acid binding protein; Belongs to the UPF0109 family. (77 aa)
Ccel_0965TIGRFAM: non-ribosomal peptide synthase; amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; phosphopantetheine-binding; KEGG: bwe:BcerKBAB4_1782 amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. (1506 aa)
Ccel_0982TIGRFAM: non-ribosomal peptide synthase; amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; phosphopantetheine-binding; KEGG: ava:Ava_4099 non-ribosomal peptide synthase. (2006 aa)
uppPBacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (281 aa)
Ccel_1370PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: cth:Cthe_1231 serine-type D-Ala-D-Ala carboxypeptidase. (440 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (424 aa)
Ccel_1555PFAM: phosphoesterase PA-phosphatase related; KEGG: tpd:Teth39_0213 phosphoesterase, PA-phosphatase related. (176 aa)
Ccel_1558KEGG: cac:CAC1540 hypothetical protein. (328 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (465 aa)
Ccel_1749PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: cth:Cthe_0679 serine-type D-Ala-D-Ala carboxypeptidase. (408 aa)
Ccel_1807PFAM: sulfatase; KEGG: cpy:Cphy_0635 sulfatase. (670 aa)
Ccel_2018KEGG: cth:Cthe_0501 hypothetical protein. (176 aa)
Ccel_2069PFAM: Mur ligase middle domain protein; domain of unknown function DUF1727; KEGG: cth:Cthe_0440 hypothetical protein. (467 aa)
Ccel_2070PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: cth:Cthe_0439 CobB/CobQ-like glutamine amidotransferase. (248 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (319 aa)
Ccel_2390TIGRFAM: non-ribosomal peptide synthase; amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; phosphopantetheine-binding; KEGG: bwe:BcerKBAB4_1782 amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. (1490 aa)
Ccel_2514KEGG: cac:CA_P0137 hypothetical protein. (369 aa)
Ccel_2590PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: amt:Amet_3113 ErfK/YbiS/YcfS/YnhG family protein. (307 aa)
Ccel_2610KEGG: oih:OB1131 hypothetical protein. (330 aa)
Ccel_2876PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: cth:Cthe_1760 1A family penicillin-binding protein. (861 aa)
amjConserved hypothetical protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (267 aa)
Ccel_3093UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (390 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (467 aa)
Ccel_3207PFAM: sulfatase; KEGG: cbb:CLD_1681 sulfatase family protein. (595 aa)
Ccel_3348PFAM: phosphoesterase PA-phosphatase related; KEGG: cbt:CLH_3231 PAP2 family protein. (186 aa)
murA-2UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (258 aa)
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.