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Ccel_0084 Ccel_0084 purC purC Ccel_0394 Ccel_0394 Ccel_0414 Ccel_0414 Ccel_0499 Ccel_0499 Ccel_0702 Ccel_0702 Ccel_0723 Ccel_0723 adk adk Ccel_1080 Ccel_1080 Ccel_1174 Ccel_1174 Ccel_1353 Ccel_1353 xpt xpt Ccel_1417 Ccel_1417 Ccel_1753 Ccel_1753 gmk gmk Ccel_1804 Ccel_1804 Ccel_1831 Ccel_1831 Ccel_1951 Ccel_1951 apt apt Ccel_2092 Ccel_2092 purD purD purH purH purN purN purM purM purF purF purE purE guaA guaA Ccel_2401 Ccel_2401 purA purA Ccel_2519 Ccel_2519 Ccel_2569 Ccel_2569 prs prs deoB deoB Ccel_3227 Ccel_3227 deoD deoD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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Ccel_0084TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
purCTIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: cth:Cthe_2885 phosphoribosylaminoimidazole-succinocarboxamide synthase. (298 aa)
Ccel_0394PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; KEGG: dsy:DSY2052 inositol-5-monophosphate dehydrogenase. (500 aa)
Ccel_0414PFAM: phosphoribosyltransferase; KEGG: ypg:YpAngola_A4140 putative phosphoribosyl transferase protein. (187 aa)
Ccel_0499TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; KEGG: cth:Cthe_0554 phosphoribosylformylglycinamidine synthase. (1256 aa)
Ccel_0702TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; KEGG: dsy:DSY0397 anaerobic ribonucleoside triphosphate reductase. (769 aa)
Ccel_0723TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: cth:Cthe_0741 adenylosuccinate lyase. (475 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
Ccel_1080PFAM: PfkB domain protein; KEGG: cbt:CLH_3246 kinase, PfkB family. (317 aa)
Ccel_1174PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: pmy:Pmen_1038 metallophosphoesterase; Belongs to the 5'-nucleotidase family. (645 aa)
Ccel_1353Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
Ccel_1417PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; KEGG: cth:Cthe_1265 alpha-phosphoglucomutase. (576 aa)
Ccel_1753PFAM: NUDIX hydrolase; KEGG: cth:Cthe_0674 NUDIX hydrolase. (180 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (201 aa)
Ccel_1804KEGG: gur:Gura_0243 metal-dependent phosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; Belongs to the dGTPase family. Type 2 subfamily. (381 aa)
Ccel_1831PFAM: RelA/SpoT domain protein; KEGG: esi:Exig_1629 RelA/SpoT domain-containing protein. (198 aa)
Ccel_1951(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (726 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa)
Ccel_2092PFAM: adenylate cyclase; KEGG: cth:Cthe_2577 adenylate cyclase. (154 aa)
purDTIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-grasp domain protein; KEGG: cth:Cthe_1245 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (419 aa)
purHTIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: cth:Cthe_1246 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (514 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: cth:Cthe_1248 phosphoribosylformylglycinamidine cyclo-ligase. (340 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (487 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (511 aa)
Ccel_2401Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (795 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (424 aa)
Ccel_2519PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: afl:Aflv_2607 protein UshA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. (523 aa)
Ccel_2569TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein mobile region; Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: csc:Csac_1831 pyruvate kinase; Belongs to the pyruvate kinase family. (580 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa)
Ccel_3227PFAM: RelA/SpoT domain protein; KEGG: cbe:Cbei_2333 RelA/SpoT domain protein. (230 aa)
deoDTIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: cpy:Cphy_0752 purine nucleoside phosphorylase. (235 aa)
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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