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Ccel_0175 Ccel_0175 Ccel_0438 Ccel_0438 Ccel_0494 Ccel_0494 Ccel_1039 Ccel_1039 Ccel_1189 Ccel_1189 Ccel_1469 Ccel_1469 Ccel_1624 Ccel_1624 glyA glyA ackA ackA Ccel_2137 Ccel_2137 Ccel_2140 Ccel_2140 Ccel_2222 Ccel_2222 pfp pfp eno eno gpmI gpmI Ccel_2373 Ccel_2373 pfkA pfkA Ccel_2918 Ccel_2918 Ccel_3425 Ccel_3425
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Ccel_0175PFAM: metalloenzyme domain protein; KEGG: cth:Cthe_2087 metalloenzyme. (297 aa)
Ccel_0438TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane; KEGG: cth:Cthe_2801 carbon-monoxide dehydrogenase, catalytic subunit. (663 aa)
Ccel_0494PFAM: AMP-dependent synthetase and ligase; KEGG: cth:Cthe_0551 AMP-dependent synthetase and ligase. (552 aa)
Ccel_1039PFAM: Pyridoxal-dependent decarboxylase; KEGG: mst:Msp_0329 MfnA. (412 aa)
Ccel_1189TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: csc:Csac_1304 D-3-phosphoglycerate dehydrogenase. (535 aa)
Ccel_1469PFAM: AMP-dependent synthetase and ligase; KEGG: cth:Cthe_0551 AMP-dependent synthetase and ligase. (559 aa)
Ccel_1624PFAM: pyruvate carboxyltransferase; KEGG: mth:MTH1630 trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
Ccel_2137TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: cth:Cthe_1029 phosphotransacetylase. (331 aa)
Ccel_2140Proposed homoserine kinase; TIGRFAM: phosphonopyruvate decarboxylase-related protein; proposed homoserine kinase; PFAM: metalloenzyme domain protein; Homoserine kinase family protein; KEGG: cth:Cthe_1292 phosphoglycerate mutase. (403 aa)
Ccel_2222TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; KEGG: cth:Cthe_0349 fructose-bisphosphate aldolase. (311 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (415 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
Ccel_2373PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: hya:HY04AAS1_1586 predicted phospho-2-dehydro-3-deoxyheptonate aldolase. (267 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
Ccel_2918TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane; KEGG: amt:Amet_1177 carbon-monoxide dehydrogenase, catalytic subunit. (710 aa)
Ccel_3425PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: ppd:Ppro_2951 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (319 aa)
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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