(43 nodes) Pyruvate metabolism, and 2-Oxocarboxylic acid metabolism network (Anaerobutyricum hallii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
	ilvD	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
	ilvB1	Acetolactate synthase large subunit IlvB1. (567 aa)
	csdB	4-hydroxyphenylacetate decarboxylase large subunit. (843 aa)
	porB_1	Pyruvate synthase subunit porB. (180 aa)
	porB_2	Pyruvate synthase subunit porB. (124 aa)
	porC	Pyruvate synthase subunit porC. (173 aa)
	dmdA_1	2%2C3-dimethylmalate dehydratase large subunit. (762 aa)
	ilvB	Acetolactate synthase large subunit. (577 aa)
	ilvH_1	Acetolactate synthase isozyme 3 small subunit. (172 aa)
	ldh_1	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (317 aa)
	cfiB_1	2-oxoglutarate carboxylase small subunit. (1154 aa)
	CUN73158.1	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
	pflB	Formate acetyltransferase. (750 aa)
	pflA	Pyruvate formate-lyase-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (250 aa)
	porA	Pyruvate synthase subunit porA. (1185 aa)
	fumA	Fumarate hydratase class I%2C aerobic. (182 aa)
	ttdA_1	L(+)-tartrate dehydratase subunit alpha. (280 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
	ilvH_2	Acetolactate synthase small subunit. (163 aa)
	pta_1	Phosphate acetyltransferase. (350 aa)
	pckA	Phosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa)
	ilvE	Branched-chain-amino-acid aminotransferase. (346 aa)
	ppdK	Pyruvate%2C phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (876 aa)
	ttdA_2	L(+)-tartrate dehydratase subunit alpha. (299 aa)
	ttdB	L(+)-tartrate dehydratase subunit beta. (208 aa)
	hpdA_1	4-hydroxyphenylacetate decarboxylase activating enzyme. (310 aa)
	hpdB_1	4-hydroxyphenylacetate decarboxylase large subunit. (865 aa)
	cfiB_2	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1188 aa)
	leuA_1	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (560 aa)
	gltA	Citrate synthase; Belongs to the citrate synthase family. (456 aa)
	ackA	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (411 aa)
	CUO94524.1	Methylmalonyl-CoA carboxyltransferase 5S subunit. (470 aa)
	gcdB	Glutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (374 aa)
	gcdC	Glutaconyl-CoA decarboxylase subunit gamma. (122 aa)
	pta_2	Phosphate acetyltransferase. (319 aa)
	maeB	NADP-dependent malic enzyme. (383 aa)
	CUO97717.1	Iron hydrogenase 1. (506 aa)
	DmdB	2%2C3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (158 aa)
	dmdA_2	2%2C3-dimethylmalate dehydratase large subunit. (417 aa)
	hacB	Homoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa)
	hacA	Homoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (412 aa)
	leuA_2	2-isopropylmalate synthase. (464 aa)

Your Current Organism:

Anaerobutyricum hallii

NCBI taxonomy Id: 39488
Other names: A. hallii, ATCC 27751, DSM 3353, Eubacterium hallii, VPI B4-27

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUN73158.1	dmdA_1	ERS852450_00538	ERS852450_00506	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	2%2C3-dimethylmalate dehydratase large subunit.	0.992
CUN73158.1	fumA	ERS852450_00538	ERS852450_01096	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Fumarate hydratase class I%2C aerobic.	0.453
CUN73158.1	gltA	ERS852450_00538	ERS852450_02532	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate synthase; Belongs to the citrate synthase family.	0.944
CUN73158.1	ilvB	ERS852450_00538	ERS852450_00507	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Acetolactate synthase large subunit.	0.661
CUN73158.1	ilvB1	ERS852450_00538	ERS852450_00251	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Acetolactate synthase large subunit IlvB1.	0.661
CUN73158.1	ldh_1	ERS852450_00538	ERS852450_00523	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.801
CUN73158.1	leuB	ERS852450_00538	ERS852450_00249	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.714
CUN73158.1	porA	ERS852450_00538	ERS852450_00975	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Pyruvate synthase subunit porA.	0.730
CUN73158.1	ppdK	ERS852450_00538	ERS852450_01980	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Pyruvate%2C phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	0.401
CUN73158.1	ttdA_1	ERS852450_00538	ERS852450_01097	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	L(+)-tartrate dehydratase subunit alpha.	0.469
CUN73158.1	ttdA_2	ERS852450_00538	ERS852450_02088	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	L(+)-tartrate dehydratase subunit alpha.	0.469
CUN73158.1	ttdB	ERS852450_00538	ERS852450_02089	Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	L(+)-tartrate dehydratase subunit beta.	0.453
CUO94524.1	DmdB	ERS852450_02719	ERS852450_03083	Methylmalonyl-CoA carboxyltransferase 5S subunit.	2%2C3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.	0.814
CUO94524.1	cfiB_1	ERS852450_02719	ERS852450_00534	Methylmalonyl-CoA carboxyltransferase 5S subunit.	2-oxoglutarate carboxylase small subunit.	0.921
CUO94524.1	cfiB_2	ERS852450_02719	ERS852450_02250	Methylmalonyl-CoA carboxyltransferase 5S subunit.	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.922
CUO94524.1	csdB	ERS852450_02719	ERS852450_00450	Methylmalonyl-CoA carboxyltransferase 5S subunit.	4-hydroxyphenylacetate decarboxylase large subunit.	0.904
CUO94524.1	dmdA_2	ERS852450_02719	ERS852450_03084	Methylmalonyl-CoA carboxyltransferase 5S subunit.	2%2C3-dimethylmalate dehydratase large subunit.	0.800
CUO94524.1	gcdB	ERS852450_02719	ERS852450_02720	Methylmalonyl-CoA carboxyltransferase 5S subunit.	Glutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).	0.991
CUO94524.1	gcdC	ERS852450_02719	ERS852450_02721	Methylmalonyl-CoA carboxyltransferase 5S subunit.	Glutaconyl-CoA decarboxylase subunit gamma.	0.970
CUO94524.1	gltA	ERS852450_02719	ERS852450_02532	Methylmalonyl-CoA carboxyltransferase 5S subunit.	Citrate synthase; Belongs to the citrate synthase family.	0.824