STRINGSTRING
CUN45892.1 CUN45892.1 hom_1 hom_1 lysC lysC luxS luxS CUN47755.1 CUN47755.1 cysS cysS aroL aroL serA serA asd2 asd2 trpD trpD aroC aroC aspC_1 aspC_1 hisZ hisZ hisG hisG hisD hisD hisB hisB hisI hisI dapF dapF dapL_1 dapL_1 aroE_1 aroE_1 metA metA thrC thrC dapA dapA dapB dapB trpB_1 trpB_1 hom_2 hom_2 CUN89974.1 CUN89974.1 hisC hisC lysA lysA CUO10914.1 CUO10914.1 mtnN mtnN serC serC metH_1 metH_1 metH_2 metH_2 metH_3 metH_3 mtnK_1 mtnK_1 mtnK_2 mtnK_2 cysE cysE mtnK_3 mtnK_3 aroB aroB trpE trpE pabA pabA trpC trpC trpF trpF trpB_2 trpB_2 trpA trpA CUO36086.1 CUO36086.1 CUO36125.1 CUO36125.1 CUO41948.1 CUO41948.1 tdcB tdcB cysK1_1 cysK1_1 mdeA_1 mdeA_1 cysK1_2 cysK1_2 aroK aroK aroE_2 aroE_2 aroD aroD aroE_3 aroE_3 gltC gltC CUO61883.1 CUO61883.1 aroE_4 aroE_4 ydiN ydiN CUO62279.1 CUO62279.1 cooS1 cooS1 pheA pheA pepA pepA CUO93869.1 CUO93869.1 CUO95164.1 CUO95164.1 hisH1 hisH1 hisF hisF hisK hisK aroG aroG CUP13821.1 CUP13821.1 CUP13866.1 CUP13866.1 mdeA_2 mdeA_2 aroA1 aroA1 metF metF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CUN45892.1ACT domain-containing protein; Belongs to the UPF0735 family. (147 aa)
hom_1Homoserine dehydrogenase. (401 aa)
lysCAspartokinase 2; Belongs to the aspartokinase family. (402 aa)
luxSS-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (159 aa)
CUN47755.1Uncharacterised protein. (304 aa)
cysSCysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (464 aa)
aroLShikimate kinase 2; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (388 aa)
asd2Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa)
aspC_1Aspartate aminotransferase. (395 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (421 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (213 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
hisBImidazoleglycerol-phosphate dehydratase. (196 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (112 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa)
dapL_1LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (404 aa)
aroE_1Shikimate dehydrogenase. (569 aa)
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (309 aa)
thrCThreonine synthase. (496 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa)
trpB_1Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (458 aa)
hom_2Homoserine dehydrogenase. (430 aa)
CUN89974.11-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m ethylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (258 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
lysADiaminopimelate decarboxylase. (417 aa)
CUO10914.1Na(+)-translocating NADH-quinone reductase subunit F. (537 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (234 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)
metH_1Methionine synthase. (823 aa)
metH_2Methionine synthase. (636 aa)
metH_3Methionine synthase. (220 aa)
mtnK_1Methylthioribose kinase. (407 aa)
mtnK_2Methylthioribose kinase. (417 aa)
cysESerine acetyltransferase. (316 aa)
mtnK_3Methylthioribose kinase. (409 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa)
trpEAnthranilate synthase component 1. (466 aa)
pabAPara-aminobenzoate synthase glutamine amidotransferase component II. (187 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase. (227 aa)
trpB_2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (390 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
CUO36086.1Prevent-host-death family protein; Antitoxin component of a type II toxin-antitoxin (TA) system. (82 aa)
CUO36125.1Addiction module toxin%2C RelE/StbE family. (99 aa)
CUO41948.1Methylcobalamin:coenzyme M methyltransferase. (284 aa)
tdcBL-threonine dehydratase catabolic TdcB. (409 aa)
cysK1_1O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
mdeA_1Methionine gamma-lyase. (436 aa)
cysK1_2O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (262 aa)
aroE_2Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (253 aa)
aroE_3Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (311 aa)
gltCHTH-type transcriptional regulator gltC; Belongs to the LysR transcriptional regulatory family. (302 aa)
CUO61883.1Hydroxypyruvate isomerase. (279 aa)
aroE_4Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (291 aa)
ydiNInner membrane transport protein ydiN. (431 aa)
CUO62279.1NADH oxidase. (667 aa)
cooS1Carbon monoxide dehydrogenase 1. (654 aa)
pheAP-protein. (380 aa)
pepACytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (491 aa)
CUO93869.1Aspartate aminotransferase. (555 aa)
CUO95164.1Phosphoserine phosphatase. (201 aa)
hisH1Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisKHistidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (271 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase%2C Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (344 aa)
CUP13821.1Bifunctional chorismate mutase/prephenate dehydratase. (287 aa)
CUP13866.1Uncharacterised protein. (227 aa)
mdeA_2Methionine gamma-lyase. (427 aa)
aroA13-phosphoshikimate 1-carboxyvinyltransferase 1; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa)
metF5%2C10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa)
Your Current Organism:
Anaerobutyricum hallii
NCBI taxonomy Id: 39488
Other names: A. hallii, ATCC 27751, DSM 3353, Eubacterium hallii, VPI B4-27
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