STRINGSTRING
recD_2 recD_2 rbr3A rbr3A lon1_2 lon1_2 dfx_1 dfx_1 recQ recQ mutY mutY CUN93073.1 CUN93073.1 pdg pdg gph_2 gph_2 dfx_2 dfx_2 ung ung uvrC uvrC recF recF CUO08976.1 CUO08976.1 CUO09900.1 CUO09900.1 exoA exoA recU recU nfo nfo mutT mutT gltD_5 gltD_5 mfd mfd cstA cstA CUO82331.1 CUO82331.1 CUO81592.1 CUO81592.1 CUO81469.1 CUO81469.1 dinB_2 dinB_2 CUO79942.1 CUO79942.1 CUO78351.1 CUO78351.1 recO recO polA_3 polA_3 addB addB addA addA recA recA trxB_2 trxB_2 mutX mutX barA barA umuC umuC lexA lexA ytkD ytkD ruvB ruvB ruvA ruvA recN recN polA_2 polA_2 CUO39337.1 CUO39337.1 mutL mutL mutS mutS dinB_1 dinB_1 CUO32188.1 CUO32188.1 recR recR mutS2 mutS2 CUO20705.1 CUO20705.1 recG_2 recG_2 CUN47354.1 CUN47354.1 CUN47392.1 CUN47392.1 radA radA recG_1 recG_1 ligA_1 ligA_1 recJ_1 recJ_1 recD_1 recD_1 CUN53559.1 CUN53559.1 CUN56805.1 CUN56805.1 comEA comEA CUN59824.1 CUN59824.1 polA_1 polA_1 recJ_2 recJ_2 gph_1 gph_1 lon1_1 lon1_1 ligA_2 ligA_2 trxB_1 trxB_1 CUN77253.1 CUN77253.1 CUN79858.1 CUN79858.1 CUN79939.1 CUN79939.1 uvrA uvrA uvrB uvrB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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recD_2Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (736 aa)
rbr3ANADH peroxidase. (180 aa)
lon1_2Lon protease 1. (494 aa)
dfx_1Superoxide reductase. (119 aa)
recQATP-dependent DNA helicase recQ. (667 aa)
mutYA/G-specific adenine glycosylase. (522 aa)
CUN93073.1Uncharacterised protein. (341 aa)
pdgUV-endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (218 aa)
gph_2Phosphoglycolate phosphatase. (215 aa)
dfx_2Superoxide reductase. (120 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (224 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (629 aa)
recFDNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (366 aa)
CUO08976.1DNA polymerase IV. (113 aa)
CUO09900.1Radical SAM superfamily. (302 aa)
exoAExodeoxyribonuclease. (250 aa)
recUHolliday junction resolvase recU; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (181 aa)
nfoProbable endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (303 aa)
mutT8-oxo-dGTP diphosphatase. (128 aa)
gltD_5Glutamate synthase [NADPH] small chain. (438 aa)
mfdTranscription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1173 aa)
cstACarbon starvation protein A. (565 aa)
CUO82331.1Predicted ATPase. (457 aa)
CUO81592.1Oxidative stress defense protein. (235 aa)
CUO81469.1Nucleoside triphosphatase YtkD. (251 aa)
dinB_2DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (414 aa)
CUO79942.1NUDIX domain. (251 aa)
CUO78351.1Site-specific DNA methylase. (274 aa)
recORecombination protein O; Involved in DNA repair and RecF pathway recombination. (245 aa)
polA_3DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (878 aa)
addBATP-dependent helicase/deoxyribonuclease subunit B; ATP-dependent DNA helicase. (1134 aa)
addAATP-dependent helicase/nuclease subunit A. (1221 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (381 aa)
trxB_2Thioredoxin reductase. (307 aa)
mutX8-oxo-dGTP diphosphatase; Belongs to the Nudix hydrolase family. (155 aa)
barASignal transduction histidine-protein kinase BarA. (488 aa)
umuCDNA polymerase IV. (490 aa)
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (208 aa)
ytkDPutative 8-oxo-dGTP diphosphatase YtkD; Belongs to the Nudix hydrolase family. (150 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (230 aa)
recNRecombination protein N; May be involved in recombinational repair of damaged DNA. (555 aa)
polA_2DNA polymerase I%2C thermostable. (477 aa)
CUO39337.1Uncharacterised protein. (282 aa)
mutLDNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (731 aa)
mutSDNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (876 aa)
dinB_1DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (200 aa)
CUO32188.1DNA polymerase IV. (168 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
mutS2MutS2 protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (791 aa)
CUO20705.1Ribosome-associated heat shock protein Hsp15. (79 aa)
recG_2ATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (673 aa)
CUN47354.1Probable DNA double-strand break repair Rad50 ATPase. (88 aa)
CUN47392.1Predicted ATP-binding protein involved in virulence. (175 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (457 aa)
recG_1ATP-dependent DNA helicase recG. (663 aa)
ligA_1DNA ligase. (645 aa)
recJ_1Single-stranded-DNA-specific exonuclease recJ. (530 aa)
recD_1Exodeoxyribonuclease V alpha chain. (690 aa)
CUN53559.1Poly(ADP-ribose) polymerase catalytic domain. (388 aa)
CUN56805.1ComEC family competence protein. (421 aa)
comEAComE operon protein 1. (203 aa)
CUN59824.1Uncharacterised protein. (132 aa)
polA_1DNA polymerase I. (644 aa)
recJ_2Single-stranded-DNA-specific exonuclease recJ. (591 aa)
gph_1Phosphoglycolate phosphatase. (220 aa)
lon1_1Lon protease 1; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (768 aa)
ligA_2DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (653 aa)
trxB_1Thioredoxin reductase. (424 aa)
CUN77253.1Sugar phosphate phosphatase. (670 aa)
CUN79858.1Probable DNA metabolism protein. (268 aa)
CUN79939.1Putative DNA modification/repair radical SAM protein. (564 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (950 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (664 aa)
Your Current Organism:
Anaerobutyricum hallii
NCBI taxonomy Id: 39488
Other names: A. hallii, ATCC 27751, DSM 3353, Eubacterium hallii, VPI B4-27
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