(23 nodes) Pyridoxal phosphate-dependent transferase, small domain network (Eubacterium ramulus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	patA	Putative aminotransferase A. (393 aa)
	patB	Cystathionine beta-lyase PatB. (389 aa)
	nifS_1	Cysteine desulfurase. (398 aa)
	nifS_2	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (395 aa)
	aspC_1	Aspartate aminotransferase. (390 aa)
	mdeA_1	Methionine gamma-lyase. (436 aa)
	aspC_2	Aspartate aminotransferase. (394 aa)
	dapL	LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (404 aa)
	mdeA_2	Methionine gamma-lyase. (427 aa)
	ltaE_1	Low specificity L-threonine aldolase. (345 aa)
	hisC	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa)
	csd_2	Probable cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (417 aa)
	glyA	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
	norG	HTH-type transcriptional regulator norG. (489 aa)
	argD	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa)
	ltaE_2	Low specificity L-threonine aldolase. (270 aa)
	CUN23477.1	Putative aminotransferase MSMEG_6286. (430 aa)
	sufS	Cysteine desulfurase. (378 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (361 aa)
	iscS	Cysteine desulfurase. (387 aa)
	hemL	Glutamate-1-semialdehyde 2%2C1-aminomutase. (428 aa)
	csd_1	Probable cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (408 aa)
	cobD	Threonine-phosphate decarboxylase. (347 aa)

Your Current Organism:

Eubacterium ramulus

NCBI taxonomy Id: 39490
Other names: ATCC 29099, DSM 3995, E. ramulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aspC_1	cobD	ERS852448_00827	ERS852448_00746	Aspartate aminotransferase.	Threonine-phosphate decarboxylase.	0.491
aspC_1	hisC	ERS852448_00827	ERS852448_02312	Aspartate aminotransferase.	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.495
aspC_1	patB	ERS852448_00827	ERS852448_00765	Aspartate aminotransferase.	Cystathionine beta-lyase PatB.	0.688
aspC_2	cobD	ERS852448_01434	ERS852448_00746	Aspartate aminotransferase.	Threonine-phosphate decarboxylase.	0.492
aspC_2	hisC	ERS852448_01434	ERS852448_02312	Aspartate aminotransferase.	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.658
aspC_2	patB	ERS852448_01434	ERS852448_00765	Aspartate aminotransferase.	Cystathionine beta-lyase PatB.	0.659
cobD	aspC_1	ERS852448_00746	ERS852448_00827	Threonine-phosphate decarboxylase.	Aspartate aminotransferase.	0.491
cobD	aspC_2	ERS852448_00746	ERS852448_01434	Threonine-phosphate decarboxylase.	Aspartate aminotransferase.	0.492
cobD	hemL	ERS852448_00746	ERS852448_00754	Threonine-phosphate decarboxylase.	Glutamate-1-semialdehyde 2%2C1-aminomutase.	0.606
cobD	patA	ERS852448_00746	ERS852448_02762	Threonine-phosphate decarboxylase.	Putative aminotransferase A.	0.446
glyA	ltaE_1	ERS852448_02415	ERS852448_02280	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Low specificity L-threonine aldolase.	0.721
glyA	ltaE_2	ERS852448_02415	ERS852448_02982	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Low specificity L-threonine aldolase.	0.721
glyA	serC	ERS852448_02415	ERS852448_00394	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.758
hemL	cobD	ERS852448_00754	ERS852448_00746	Glutamate-1-semialdehyde 2%2C1-aminomutase.	Threonine-phosphate decarboxylase.	0.606
hisC	aspC_1	ERS852448_02312	ERS852448_00827	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Aspartate aminotransferase.	0.495
hisC	aspC_2	ERS852448_02312	ERS852448_01434	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Aspartate aminotransferase.	0.658
hisC	patA	ERS852448_02312	ERS852448_02762	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Putative aminotransferase A.	0.418
iscS	nifS_1	ERS852448_00412	ERS852448_00767	Cysteine desulfurase.	Cysteine desulfurase.	0.702
iscS	nifS_2	ERS852448_00412	ERS852448_00823	Cysteine desulfurase.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.	0.700
ltaE_1	glyA	ERS852448_02280	ERS852448_02415	Low specificity L-threonine aldolase.	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.721