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leuB_1 leuB_1 dmdA_1 dmdA_1 ilvD ilvD ttdA ttdA accB accB accD accD accA accA gcdB gcdB CUQ83156.1 CUQ83156.1 leuA leuA fumB fumB ppdK ppdK prpC prpC maeB maeB tdcB tdcB ilvC ilvC ilvH_1 ilvH_1 ilvB_1 ilvB_1 leuB_2 leuB_2 DmdB DmdB dmdA_2 dmdA_2 ilvH_2 ilvH_2 ilvB_2 ilvB_2 porA_1 porA_1 pckG pckG pflA_2 pflA_2 pflB pflB ilvK ilvK porA_2 porA_2 porB porB adhE_2 adhE_2
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
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leuB_13-isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa)
dmdA_12%2C3-dimethylmalate dehydratase large subunit. (649 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
ttdAL(+)-tartrate dehydratase subunit alpha. (280 aa)
accBBiotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (295 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (269 aa)
gcdBGlutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (412 aa)
CUQ83156.1Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase%2C gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (138 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (558 aa)
fumBFumarate hydratase class I%2C anaerobic. (181 aa)
ppdKPyruvate%2C phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (876 aa)
prpC2-methylcitrate synthase; Belongs to the citrate synthase family. (446 aa)
maeBNADP-dependent malic enzyme. (386 aa)
tdcBL-threonine dehydratase catabolic TdcB; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (397 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (345 aa)
ilvH_1Acetolactate synthase small subunit. (163 aa)
ilvB_1Acetolactate synthase large subunit. (543 aa)
leuB_23-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
DmdB2%2C3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
dmdA_22%2C3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
ilvH_2Acetolactate synthase small subunit. (157 aa)
ilvB_2Acetolactate synthase large subunit. (564 aa)
porA_1Pyruvate synthase subunit porA. (1183 aa)
pckGPhosphoenolpyruvate carboxykinase [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (593 aa)
pflA_2Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (237 aa)
pflBFormate acetyltransferase. (752 aa)
ilvKBranched-chain-amino-acid aminotransferase 2. (354 aa)
porA_2Pyruvate synthase subunit porA. (355 aa)
porBPyruvate synthase subunit porB. (246 aa)
adhE_2Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (885 aa)
Your Current Organism:
Eubacterium siraeum
NCBI taxonomy Id: 39492
Other names: ATCC 29066, DSM 15702, DSM 3996, [. siraeum, [Eubacterium] siraeum
Server load: medium (42%) [HD]
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