STRINGSTRING
maeB maeB fumC fumC acs acs acs-2 acs-2 fumA fumA icd icd icd-2 icd-2 gltA gltA sucD sucD sucC sucC BAG44783.1 BAG44783.1 BAG44918.1 BAG44918.1 maeB-2 maeB-2 BAG45007.1 BAG45007.1 acnB acnB BAG45277.1 BAG45277.1 acnA acnA prpD prpD citE citE mdh mdh gltA-2 gltA-2 ach1 ach1 BAG46670.1 BAG46670.1 acs-3 acs-3 prpF prpF acnA-2 acnA-2 prpC prpC prpB prpB yfiQ yfiQ acs-4 acs-4 ackA ackA ptb ptb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
maeBNADP-dependent oxaloacetate-decarboxylating malate dehydrogenase; COG0281: Malic enzyme, Ralstonia solanacearum; KEGG, K00029. (766 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
acsCOG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Mesorhizobium loti; KEGG, K01895. (539 aa)
acs-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
fumAClass I fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
icdCOG2838: Monomeric isocitrate dehydrogenase, Xylella fastidiosa 9a5c; KEGG, K00031; Belongs to the monomeric-type IDH family. (741 aa)
icd-2COG0538: Isocitrate dehydrogenases, Ralstonia solanacearum; KEGG, K00031. (418 aa)
gltACOG0372: Citrate synthase, Agrobacterium tumefaciens strain C58. (410 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
BAG44783.1COG4231: Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits, Ralstonia solanacearum; KEGG, K04090. (1190 aa)
BAG44918.1COG4231: Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits, Ralstonia solanacearum; KEGG, K04090. (1196 aa)
maeB-2NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase; COG0281: Malic enzyme, Ralstonia solanacearum; KEGG, K00029; Belongs to the malic enzymes family. (756 aa)
BAG45007.1COG1012: NAD-dependent aldehyde dehydrogenases, Deinococcus radiodurans; KEGG, K00128; Belongs to the aldehyde dehydrogenase family. (508 aa)
acnBAconitate hydratase 2; COG1049: Aconitase B, Xylella fastidiosa 9a5c; KEGG, K01682; Belongs to the aconitase/IPM isomerase family. (861 aa)
BAG45277.1COG2513: PEP phosphonomutase and related enzymes, Sinorhizobium meliloti. (253 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
prpD2-methylcitrate dehydratase; COG2079: Uncharacterized protein involved in propionate catabolism, Ralstonia solanacearum; KEGG, K01720. (484 aa)
citECOG2301: Citrate lyase beta subunit, Ralstonia solanacearum; KEGG, K01644; Belongs to the HpcH/HpaI aldolase family. (335 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
gltA-2COG0372: Citrate synthase, Ralstonia solanacearum; KEGG, K01647. (433 aa)
ach1COG0427: Acetyl-CoA hydrolase, Caulobacter vibrioides; KEGG, K01067. (504 aa)
BAG46670.1COG2513: PEP phosphonomutase and related enzymes, Ralstonia solanacearum. (286 aa)
acs-3COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Ralstonia solanacearum; KEGG, K01895. (568 aa)
prpFProbable AcnD-accessory protein; COG2828: Uncharacterized protein conserved in bacteria, Ralstonia solanacearum; PrpF protein. (396 aa)
acnA-2Aconitate hydratase 1; COG1048: Aconitase A, Ralstonia solanacearum; KEGG, K01681. (865 aa)
prpCCOG0372: Citrate synthase, Ralstonia solanacearum; KEGG, K01659. (390 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (297 aa)
yfiQConserved hypothetical protein; COG1042: Acyl-CoA synthetase (NDP forming), Mesorhizobium loti; KEGG, K09181. (785 aa)
acs-4acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
ptbPhosphate butyryltransferase; COG0280: Phosphotransacetylase, Rickettsia prowazekii; KEGG, K00634. (343 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.