STRINGSTRING
dnaN dnaN dnaA dnaA topB topB holA holA recN recN mutL mutL dnaQ dnaQ uvrC uvrC dnaQ-2 dnaQ-2 rnhA rnhA uvrD uvrD BAG43314.1 BAG43314.1 lexA lexA dinG dinG dnaX dnaX dnaB dnaB holB holB mfd mfd rnhA-2 rnhA-2 sms sms mutS mutS dinB dinB uvrB uvrB dnaE dnaE holC holC recX recX recA recA ssb ssb uvrA uvrA dnaE-2 dnaE-2 BAG44668.1 BAG44668.1 BAG44669.1 BAG44669.1 recQ recQ BAG44946.1 BAG44946.1 rep-2 rep-2 priA priA polB polB polA polA dnaG dnaG recQ-2 recQ-2 ssb-2 ssb-2 uvrA-2 uvrA-2 BAG47959.1 BAG47959.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaNDNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (368 aa)
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (524 aa)
topBCOG0550: Topoisomerase IA, Ralstonia solanacearum; KEGG, K01862. (865 aa)
holACOG1466: DNA polymerase III, delta subunit, Ralstonia solanacearum; KEGG, K02340. (364 aa)
recNDNA repair protein; May be involved in recombinational repair of damaged DNA. (549 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (662 aa)
dnaQCOG0847: DNA polymerase III, epsilon subunit and related 3'-5' exonucleases, Neisseria meningitidis Z2491; KEGG, K02342. (375 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (674 aa)
dnaQ-2DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (244 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (147 aa)
uvrDCOG0210: Superfamily I DNA and RNA helicases, Ralstonia solanacearum; KEGG, K03657. (786 aa)
BAG43314.1Putative calcineurin-like metallophosphoesterase. (276 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (215 aa)
dinGCOG1199: Rad3-related DNA helicases, Ralstonia solanacearum; DinG protein; KEGG, K03722. (750 aa)
dnaXCOG2812: DNA polymerase III, gamma/tau subunits, Ralstonia solanacearum; KEGG, K02343. (821 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (460 aa)
holBDNA polymerase III delta' subunit; COG0470: ATPase involved in DNA replication, Ralstonia solanacearum; KEGG, K02341. (342 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1185 aa)
rnhA-2Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (210 aa)
smsDNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (458 aa)
mutSDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (388 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (704 aa)
dnaECOG0587: DNA polymerase III, alpha subunit, Ralstonia solanacearum; KEGG, K02337. (1179 aa)
holCCOG2927: DNA polymerase III, chi subunit, Ralstonia solanacearum; KEGG, K02339. (138 aa)
recXRegulatory protein; Modulates RecA activity; Belongs to the RecX family. (285 aa)
recARecombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (348 aa)
ssbSingle-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (182 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (961 aa)
dnaE-2DNA polymerase III alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1071 aa)
BAG44668.1COG0389: Nucleotidyltransferase/DNA polymerase involved in DNA repair, Ralstonia solanacearum; involved in DNA repair. (495 aa)
BAG44669.1Conserved hypothetical protein. (235 aa)
recQCOG0514: Superfamily II DNA helicase, Ralstonia solanacearum; KEGG, K03654; RecQ protein. (615 aa)
BAG44946.1Conserved hypothetical protein. (219 aa)
rep-2ATP-dependent DNA helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (695 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (757 aa)
polBCOG0417: DNA polymerase elongation subunit (family B), Pseudomonas aeruginosa; KEGG, K02336. (791 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (917 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (622 aa)
recQ-2ATP-dependent DNA helicase; KEGG, K03654; RecQ protein. (607 aa)
ssb-2Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (184 aa)
uvrA-2Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1974 aa)
BAG47959.1COG0420: DNA repair exonuclease, Sinorhizobium meliloti. (416 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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