STRINGSTRING
topB topB recN recN mutL mutL BAG43314.1 BAG43314.1 lexA lexA dinG dinG mutS mutS dinB dinB recA recA BAG44668.1 BAG44668.1 BAG44669.1 BAG44669.1 recQ recQ rep-2 rep-2 polB polB polA polA recQ-2 recQ-2 BAG47959.1 BAG47959.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
topBCOG0550: Topoisomerase IA, Ralstonia solanacearum; KEGG, K01862. (865 aa)
recNDNA repair protein; May be involved in recombinational repair of damaged DNA. (549 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (662 aa)
BAG43314.1Putative calcineurin-like metallophosphoesterase. (276 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (215 aa)
dinGCOG1199: Rad3-related DNA helicases, Ralstonia solanacearum; DinG protein; KEGG, K03722. (750 aa)
mutSDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (388 aa)
recARecombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (348 aa)
BAG44668.1COG0389: Nucleotidyltransferase/DNA polymerase involved in DNA repair, Ralstonia solanacearum; involved in DNA repair. (495 aa)
BAG44669.1Conserved hypothetical protein. (235 aa)
recQCOG0514: Superfamily II DNA helicase, Ralstonia solanacearum; KEGG, K03654; RecQ protein. (615 aa)
rep-2ATP-dependent DNA helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (695 aa)
polBCOG0417: DNA polymerase elongation subunit (family B), Pseudomonas aeruginosa; KEGG, K02336. (791 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (917 aa)
recQ-2ATP-dependent DNA helicase; KEGG, K03654; RecQ protein. (607 aa)
BAG47959.1COG0420: DNA repair exonuclease, Sinorhizobium meliloti. (416 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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