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glmS glmS glmU glmU scrK scrK rpe rpe tktA tktA gapD gapD edd edd eda-2 eda-2 gntK gntK gpm gpm glmS-2 glmS-2 glk glk pgl pgl zwf zwf fbp1 fbp1 glmM glmM scrK-2 scrK-2 nanK nanK rpiA rpiA BAG43537.1 BAG43537.1 rbsK rbsK kdgK-2 kdgK-2 pgi pgi ppsA ppsA BAG43891.1 BAG43891.1 eno eno tpiA tpiA talA talA ppc ppc fbaA fbaA pyk pyk pgk pgk glpR glpR ptsN ptsN prsA prsA pts-Nag-EIIB pts-Nag-EIIB pts-EI pts-EI BAG44664.1 BAG44664.1 nagA nagA BAG44666.1 BAG44666.1 gpm-2 gpm-2 pts-EI-2 pts-EI-2 pts-HPR pts-HPR pts-Unk-EIIA pts-Unk-EIIA nagK nagK glmS-3 glmS-3 BAG45230.1 BAG45230.1 BAG45395.1 BAG45395.1 BAG45396.1 BAG45396.1 gnd gnd gntR gntR glmS-4 glmS-4 pckA pckA fruR1 fruR1 BAG46914.1 BAG46914.1 zwf-2 zwf-2 BAG47164.1 BAG47164.1 ppsA-2 ppsA-2 fruK fruK
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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glmSGlucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (453 aa)
scrKFructokinase; COG0524: Sugar kinases, ribokinase family, Deinococcus radiodurans; KEGG, K00847. (302 aa)
rpeCOG0036: Pentose-5-phosphate-3-epimerase, Ralstonia solanacearum; KEGG, K01783; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
tktACOG0021: Transketolase, Ralstonia solanacearum; KEGG, K00615; Belongs to the transketolase family. (690 aa)
gapDCOG0057: Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase, Pseudomonas aeruginosa; KEGG, K00134; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (618 aa)
eda-2COG0800: 2-keto-3-deoxy-6-phosphogluconate aldolase, Ralstonia solanacearum; KEGG, K01625. (208 aa)
gntKGluconokinase; COG3265: Gluconate kinase, Ralstonia solanacearum; KEGG, K00851. (167 aa)
gpmPhosphoglycerate mutase; COG0406: Fructose-2,6-bisphosphatase, Ralstonia solanacearum; KEGG, K01834. (220 aa)
glmS-2Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
glkCOG0837: Glucokinase, Neisseria meningitidis Z2491; KEGG, K00845; Belongs to the bacterial glucokinase family. (642 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (226 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
fbp1COG0158: Fructose-1,6-bisphosphatase, Ralstonia solanacearum; KEGG, K03841. (337 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (451 aa)
scrK-2Fructokinase; COG0524: Sugar kinases, ribokinase family, Ralstonia solanacearum; KEGG, K00847. (319 aa)
nanKCOG1940: Transcriptional regulator/sugar kinase, Agrobacterium tumefaciens strain C58; KEGG, K00885. (416 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa)
BAG43537.1COG1609: Transcriptional regulators, Pseudomonas aeruginosa; KEGG, K02529. (343 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (310 aa)
kdgK-22-dehydro-3-deoxygluconokinase; COG0524: Sugar kinases, ribokinase family, Ralstonia solanacearum; KEGG, K00874. (308 aa)
pgiCOG0166: Glucose-6-phosphate isomerase, Deinococcus radiodurans; KEGG, K01810; Belongs to the GPI family. (540 aa)
ppsAATP:pyruvate, water phosphotransferase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa)
BAG43891.1Conserved hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (271 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
talATransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1004 aa)
fbaAClass II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pykCOG0469: Pyruvate kinase, Ralstonia solanacearum; KEGG, K00873. (478 aa)
pgkCOG0126: 3-phosphoglycerate kinase, Ralstonia solanacearum; KEGG, K00927. (398 aa)
glpRGlycerol-3-phosphate regulon repressor; COG1349: Transcriptional regulators of sugar metabolism, Ralstonia solanacearum; KEGG, K02444. (259 aa)
ptsNPTS system nitrogen regulatory IIA component; COG1762: Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type), Ralstonia solanacearum; KEGG, K02806. (151 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa)
pts-Nag-EIIBCOG1263: Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific, Pseudomonas aeruginosa; KEGG, K02803. (596 aa)
pts-EICOG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria), Pseudomonas aeruginosa; KEGG, K02766; Belongs to the PEP-utilizing enzyme family. (860 aa)
BAG44664.1COG2222: Predicted phosphosugar isomerases, Pseudomonas aeruginosa; KEGG, K01504. (335 aa)
nagACOG1820: N-acetylglucosamine-6-phosphate deacetylase, Pseudomonas aeruginosa; KEGG, K01443. (367 aa)
BAG44666.1COG2188: Transcriptional regulators, Pseudomonas aeruginosa; KEGG, K03710. (244 aa)
gpm-2Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
pts-EI-2Phosphotransferase system enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (590 aa)
pts-HPRPhosphocarrier protein HPr; COG1925: Phosphotransferase system, HPr-related proteins, Ralstonia solanacearum; KEGG, K02784. (89 aa)
pts-Unk-EIIACOG2893: Phosphotransferase system, mannose/fructose-specific component IIA, Ralstonia solanacearum; KEGG, K02821. (156 aa)
nagKCOG2971: Predicted N-acetylglucosamine kinase, Mesorhizobium loti; KEGG, K00884. (293 aa)
glmS-3Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
BAG45230.1COG1012: NAD-dependent aldehyde dehydrogenases, Pseudomonas aeruginosa. (542 aa)
BAG45395.1COG3958: Transketolase, C-terminal subunit, Mesorhizobium loti; KEGG, K00615; contains putative C-terminal regulatory molecule-binding domain. (332 aa)
BAG45396.1COG3959: Transketolase, N-terminal subunit, Mesorhizobium loti; KEGG, K00615. (281 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (470 aa)
gntRLacI family gluconate utilization system Gnt-I transcriptional repressor; COG1609: Transcriptional regulators, Agrobacterium tumefaciens strain C58; KEGG, K06145. (335 aa)
glmS-4Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (607 aa)
pckAGTP-dependent phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (621 aa)
fruR1LacI family fructose operon transcriptional repressor; COG1609: Transcriptional regulators, Agrobacterium tumefaciens strain C58; KEGG, K03435. (354 aa)
BAG46914.1COG1349: Transcriptional regulators of sugar metabolism, Sinorhizobium meliloti. (252 aa)
zwf-2Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
BAG47164.1LacI family putative ribose operon repressor; COG1609: Transcriptional regulators, Ralstonia solanacearum. (338 aa)
ppsA-2Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (803 aa)
fruK1-phosphofructokinase; COG1105: Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB), Mycobacterium tuberculosis CDC1551; KEGG, K00882; Belongs to the carbohydrate kinase PfkB family. (311 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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