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| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (243 aa) |
| | BAG44580.1 | COG0500: SAM-dependent methyltransferases, Ralstonia solanacearum. (208 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (275 aa) |
| | cfa | COG2230: Cyclopropane fatty acid synthase and related methyltransferases, Ralstonia solanacearum; KEGG, K00574. (406 aa) |
| | ada-2 | methylated-DNA-[protein]-cysteine S-methyltransferase; COG0350: Methylated DNA-protein cysteine methyltransferase, Ralstonia solanacearum; KEGG, K00567. (156 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (309 aa) |
| | BAG44394.1 | COG0500: SAM-dependent methyltransferases, Ralstonia solanacearum. (201 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (220 aa) |
| | sun-2 | Sun protein; COG0144: tRNA and rRNA cytosine-C5-methylases, Ralstonia solanacearum; KEGG, K03500; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (421 aa) |
| | cysG-2 | uroporphyrin-III C-methyltransferase; COG0007: Uroporphyrinogen-III methylase, Ralstonia solanacearum; KEGG, K02302; Belongs to the precorrin methyltransferase family. (252 aa) |
| | BAG44285.1 | COG0500: SAM-dependent methyltransferases, Escherichia coli O157:H7. (250 aa) |
| | hemX | uroporphyrin-III C-methyltransferase; COG1587: Uroporphyrinogen-III synthase, Ralstonia solanacearum; KEGG, K02496. (656 aa) |
| | pcm-3 | protein-L-isoaspartate (D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (675 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (404 aa) |
| | ybeA | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (156 aa) |
| | rlmJ | Conserved hypothetical protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (281 aa) |
| | BAG43985.1 | COG0500: SAM-dependent methyltransferases, Ralstonia solanacearum. (200 aa) |
| | lasT | tRNA/rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (276 aa) |
| | accA | acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa) |
| | yfcB | Putative adenine-specific DNA-methyltransferase; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (302 aa) |
| | spoU | TrmH family RNA methyltransferase; COG0566: rRNA methylases, Ralstonia solanacearum; KEGG, K03437. (260 aa) |
| | fmt-2 | COG0223: Methionyl-tRNA formyltransferase, Ralstonia solanacearum; KEGG, K00604. (315 aa) |
| | pcm-2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (309 aa) |
| | rlmD | SAM-dependent methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (465 aa) |
| | rlmN | Cfr family radical SAM enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (378 aa) |
| | BAG43630.1 | Conserved hypothetical protein. (143 aa) |
| | cobM | COG2875: Precorrin-4 methylase, Pseudomonas aeruginosa; KEGG, K00596. (242 aa) |
| | cbiD | Cobalamin biosynthesis protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (362 aa) |
| | BAG43149.1 | COG0500: SAM-dependent methyltransferases, Ralstonia solanacearum. (270 aa) |
| | ftsJ | Cell division protein methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (220 aa) |
| | dcm | DNA (cytosine-5-)-methyltransferase; KEGG, K00558. (380 aa) |
| | yjfH | TrmH family RNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (247 aa) |
| | pvdF | Ornibactin synthetase F. (279 aa) |
| | cysG | uroporphyrin-III C-methyltransferase; COG0007: Uroporphyrinogen-III methylase, Pseudomonas aeruginosa; KEGG, K02302. (254 aa) |
| | cobJ | COG1010: Precorrin-3B methylase, Pseudomonas aeruginosa; KEGG, K00594. (571 aa) |
| | cobI | Precorrin-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. (244 aa) |
| | cobL | precorrin-6Y C5,15-methyltransferase; COG2242: Precorrin-6B methylase 2, Pseudomonas aeruginosa; KEGG, K00595. (412 aa) |
| | sun | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (467 aa) |
| | metW | Methionine biosynthesis protein; COG0500: SAM-dependent methyltransferases, Ralstonia solanacearum; MetW protein. (202 aa) |
| | BAG42126.1 | COG1092: Predicted SAM-dependent methyltransferases, Ralstonia solanacearum; KEGG, K06969. (404 aa) |
| | BAG42236.1 | COG1565: Uncharacterized conserved protein, Ralstonia solanacearum. (396 aa) |
| | BAG42307.1 | COG2890: Methylase of polypeptide chain release factors, Ralstonia solanacearum; Belongs to the methyltransferase superfamily. (377 aa) |
| | BAG42308.1 | COG0500: SAM-dependent methyltransferases, Ralstonia solanacearum. (296 aa) |
| | hemK | HemK protein; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (280 aa) |
| | mraW | S-adenosyl-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa) |
| | pilD | Leader peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (303 aa) |
| | prmA | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (300 aa) |
| | BAG42453.1 | Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (254 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase; COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful), Ralstonia solanacearum; KEGG, K00602. (521 aa) |
| | BAG42525.1 | COG0116: Predicted N6-adenine-specific DNA methylase, Ralstonia solanacearum; KEGG, K07444; Belongs to the methyltransferase superfamily. (432 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | pyrB | COG0540: Aspartate carbamoyltransferase, catalytic chain, Ralstonia solanacearum; KEGG, K00609; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (343 aa) |
| | pcm | protein-L-isoaspartate (D-aspartate) O-methyltransferase; COG2518: Protein-L-isoaspartate carboxylmethyltransferase, Ralstonia solanacearum; KEGG, K00573. (217 aa) |
| | trmB | tRNA (guanine-N7-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (254 aa) |
| | BAG42851.1 | Conserved hypothetical protein; COG2020: Putative protein-S-isoprenylcysteine methyltransferase, Nostoc sp. PCC 7120. (215 aa) |
| | BAG42909.1 | COG0863: DNA modification methylase, Ralstonia solanacearum. (421 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (232 aa) |
| | trmD | tRNA (guanine-N1-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (264 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa) |
| | BAG42997.1 | Methyltransferase; COG0313: Predicted methyltransferases, Ralstonia solanacearum; KEGG, K07056. (240 aa) |
| | pcc | COG0777: Acetyl-CoA carboxylase beta subunit, Pseudomonas aeruginosa; KEGG, K01964. (310 aa) |
| | BAG47723.1 | Conserved hypothetical protein. (333 aa) |
| | cfa-3 | COG2230: Cyclopropane fatty acid synthase and related methyltransferases, Caulobacter vibrioides; KEGG, K00574. (366 aa) |
| | cfa-2 | COG2230: Cyclopropane fatty acid synthase and related methyltransferases, Caulobacter vibrioides; KEGG, K00574. (405 aa) |
| | vanA | Putative vanillate o-demethylase oxygenase subunit; COG4638: Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit, Ralstonia solanacearum; KEGG, K03862. (347 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | pyrB-2 | COG0540: Aspartate carbamoyltransferase, catalytic chain, Methanothermobacter thermautotrophicus; KEGG, K00609. (431 aa) |
| | BAG46532.1 | Bacteriophage DNA methylase. (159 aa) |
| | BAG46346.1 | Putative O-methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. (286 aa) |
| | BAG46272.1 | COG3665: Uncharacterized conserved protein, Schizosaccharomyces pombe. (286 aa) |
| | cysG-3 | uroporphyrin-III C-methyltransferase; COG0007: Uroporphyrinogen-III methylase, Pseudomonas aeruginosa; KEGG, K02302. (251 aa) |
| | BAG46196.1 | Putative SAM-dependent methyltransferase. (278 aa) |
| | BAG46185.1 | COG0500: SAM-dependent methyltransferases, Mesorhizobium loti. (272 aa) |
| | BAG46096.1 | COG3189: Uncharacterized conserved protein, Ralstonia solanacearum. (132 aa) |
| | BAG46089.1 | Methylase; Involved in ubiquinone/menaquinone biosynthesis-like protein. (243 aa) |
| | BAG46016.1 | Conserved hypothetical protein. (609 aa) |
| | BAG45934.1 | COG0500: SAM-dependent methyltransferases, Mesorhizobium loti. (284 aa) |
| | accD | acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | yhdJ-2 | Putative adenine-specific DNA-methyltransferase; COG0863: DNA modification methylase, Ralstonia solanacearum; KEGG, K07319; Belongs to the N(4)/N(6)-methyltransferase family. (283 aa) |
| | BAG45697.1 | Putative SAM-dependent methyltransferase. (213 aa) |
| | BAG45685.1 | O-methyltransferase family protein; COG4122: Predicted O-methyltransferase, Pseudomonas aeruginosa. (219 aa) |
| | BAG45651.1 | Hypothetical protein. (317 aa) |
| | BAG45650.1 | COG4422: Bacteriophage protein gp37, Mycobacterium tuberculosis CDC1551. (285 aa) |
| | BAG45649.1 | Hypothetical protein. (423 aa) |
| | yhdJ | Putative adenine-specific DNA-methyltransferase; COG0863: DNA modification methylase, Xylella fastidiosa 9a5c; KEGG, K07319; Belongs to the N(4)/N(6)-methyltransferase family. (249 aa) |
| | BAG45490.1 | COG0500: SAM-dependent methyltransferases, Agrobacterium tumefaciens strain C58. (234 aa) |
| | cheR-2 | COG1352: Methylase of chemotaxis methyl-accepting proteins, Ralstonia solanacearum; CheR protein; KEGG, K00575. (479 aa) |
| | BAG45357.1 | COG0500: SAM-dependent methyltransferases, Mesorhizobium loti. (255 aa) |
| | BAG45356.1 | O-methyltransferase family protein; COG4122: Predicted O-methyltransferase, Mesorhizobium loti; KEGG, K00599. (222 aa) |
| | ada-4 | methylated-DNA-[protein]-cysteine S-methyltransferase; COG2169: Adenosine deaminase, Ralstonia solanacearum; KEGG, K00567. (487 aa) |
| | ada-3 | methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (177 aa) |
| | gidB | Glucose inhibited division protein B; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (228 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa) |
| | cheR | COG1352: Methylase of chemotaxis methyl-accepting proteins, Ralstonia solanacearum; CheR protein; KEGG, K00575. (328 aa) |
| | rsmI | Methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (292 aa) |
| | metH-2 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (905 aa) |
| | metH | COG0646: Methionine synthase I (cobalamin-dependent), methyltransferase domain, Ralstonia solanacearum; KEGG, K00548. (356 aa) |
| | cspR | TrmH family RNA methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (156 aa) |
| | bioC | Biotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (321 aa) |
| | BAG44650.1 | COG0742: N6-adenine-specific methylase, Ralstonia solanacearum; KEGG, K00599. (204 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | mnmC | Conserved hypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (657 aa) |
| | mod | Adenine-specific DNA methyltransferase; COG2189: Adenine specific DNA methylase Mod, Listeria innocua; KEGG, K07316. (668 aa) |
| | BAG42031.1 | COG4301: Uncharacterized conserved protein, Nostoc sp. PCC 7120. (318 aa) |
| | ada | methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. (365 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (327 aa) |
