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ttcA ttcA BAG42454.1 BAG42454.1 trmU trmU scoA scoA scoB scoB phnB phnB pvdF pvdF rimO rimO lipA-2 lipA-2 moaE moaE iscS iscS phnB-2 phnB-2 miaB miaB fdhD fdhD lipA-3 lipA-3 bioB bioB thiG thiG pcaI pcaI pcaJ pcaJ iscS-2 iscS-2 sseA-3 sseA-3 ach1 ach1 BAG46033.1 BAG46033.1 BAG46081.1 BAG46081.1 BAG46666.1 BAG46666.1 fdhD-2 fdhD-2 moaE-2 moaE-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ttcAPredicted ATPase of the PP-loop superfamily implicated in cell cycle control; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (331 aa)
BAG42454.1glyoxalase/Bleomycin resistance protein; COG2764: Uncharacterized protein conserved in bacteria, Ralstonia solanacearum. (138 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (381 aa)
scoACOG1788: Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit, Ralstonia solanacearum; KEGG, K01028. (234 aa)
scoBCOG2057: Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit, Deinococcus radiodurans; KEGG, K01029. (213 aa)
phnBPhnB protein; COG2764: Uncharacterized protein conserved in bacteria, Ralstonia solanacearum; KEGG, K04750. (157 aa)
pvdFOrnibactin synthetase F. (279 aa)
rimOPutative 2-methylthioadenine synthetase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (453 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
moaEMolybdenum cofactor biosynthesis protein E; COG0314: Molybdopterin converting factor, large subunit, Ralstonia solanacearum; KEGG, K03635. (158 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (407 aa)
phnB-2PhnB protein; COG2764: Uncharacterized protein conserved in bacteria, Ralstonia solanacearum; KEGG, K04750. (149 aa)
miaBBifunctional enzyme; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (457 aa)
fdhDFdhD protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (274 aa)
lipA-3Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (330 aa)
bioBBiotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (339 aa)
thiGThiamine biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (271 aa)
pcaICOG1788: Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit, Ralstonia solanacearum; KEGG, K01031. (237 aa)
pcaJCOG2057: Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit, Ralstonia solanacearum; KEGG, K01032. (217 aa)
iscS-2COG1104: Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes, Pseudomonas aeruginosa; KEGG, K04487. (492 aa)
sseA-3COG2897: Rhodanese-related sulfurtransferase, Ralstonia solanacearum; KEGG, K01010. (289 aa)
ach1COG0427: Acetyl-CoA hydrolase, Caulobacter vibrioides; KEGG, K01067. (504 aa)
BAG46033.1COG0607: Rhodanese-related sulfurtransferase, Pseudomonas aeruginosa. (542 aa)
BAG46081.1COG2764: Uncharacterized protein conserved in bacteria, Mesorhizobium loti. (153 aa)
BAG46666.1COG0607: Rhodanese-related sulfurtransferase, Vibrio cholerae. (141 aa)
fdhD-2FdhD protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (284 aa)
moaE-2Molybdenum cofactor biosynthesis protein E; COG0314: Molybdopterin converting factor, large subunit, Ralstonia solanacearum; KEGG, K03635. (187 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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