STRINGSTRING
bioD bioD argG argG BAG45573.1 BAG45573.1 folC folC BAG46248.1 BAG46248.1 BAG46253.1 BAG46253.1 amiE-3 amiE-3 BAG46562.1 BAG46562.1 asnB asnB glnA-4 glnA-4 nadE-2 nadE-2 gatA-4 gatA-4 purA-2 purA-2 BAG41986.1 BAG41986.1 gshA gshA exsB exsB gatC gatC gatA gatA gatB gatB BAG42177.1 BAG42177.1 glnA glnA murE murE murF murF murD murD murC murC ddlA ddlA accC accC mpl mpl purM purM pncB pncB carA carA carB carB cobB cobB purA purA purL purL guaA guaA mesJ mesJ pyrG pyrG glnA-2 glnA-2 glnA-3 glnA-3 purD purD nadE nadE panC panC dfp dfp purK purK purC purC gshB gshB pncB-2 pncB-2 birA birA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa)
argGCOG0137: Argininosuccinate synthase, Ralstonia solanacearum; KEGG, K01940; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (445 aa)
BAG45573.1COG1610: Uncharacterized conserved protein, Ralstonia solanacearum; KEGG, K09117. (148 aa)
folCCOG0285: Folylpolyglutamate synthase, Ralstonia solanacearum; KEGG, K01930. (436 aa)
BAG46248.1COG2308: Uncharacterized conserved protein, Pseudomonas aeruginosa. (868 aa)
BAG46253.1COG2308: Uncharacterized conserved protein, Mesorhizobium loti. (476 aa)
amiE-3Amidase; COG0154: Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases, Sinorhizobium meliloti; KEGG, K01426. (448 aa)
BAG46562.1Conserved hypothetical protein. (295 aa)
asnBCOG0367: Asparagine synthase (glutamine-hydrolyzing), Mesorhizobium loti; KEGG, K01953. (655 aa)
glnA-4COG0174: Glutamine synthetase, Pseudomonas aeruginosa; KEGG, K01915. (448 aa)
nadE-2NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (292 aa)
gatA-4COG0154: Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases, Caulobacter vibrioides. (442 aa)
purA-2Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
BAG41986.1Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (371 aa)
gshAGlutamate-cysteine ligase; COG2918: Gamma-glutamylcysteine synthetase, Pseudomonas aeruginosa; KEGG, K01919; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (533 aa)
exsBExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (244 aa)
gatCaspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa)
gatAaspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (499 aa)
gatBaspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (491 aa)
BAG42177.1Putative 5-formyltetrahydrofolate cyclo-ligase family protein; COG0212: 5-formyltetrahydrofolate cyclo-ligase, Ralstonia solanacearum. (198 aa)
glnACOG0174: Glutamine synthetase, Caulobacter vibrioides; KEGG, K01915. (445 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (513 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (468 aa)
murDUDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (503 aa)
murCUDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (465 aa)
ddlAD-alanine-D-alanine ligase; Cell wall formation. (313 aa)
accCacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
mplUDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (461 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COG0150: Phosphoribosylaminoimidazole (AIR) synthetase, Ralstonia solanacearum; KEGG, K01933. (351 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (399 aa)
carACOG0505: Carbamoylphosphate synthase small subunit, Ralstonia solanacearum; KEGG, K01956; Belongs to the CarA family. (381 aa)
carBCOG0458: Carbamoylphosphate synthase large subunit (split gene in MJ), Ralstonia solanacearum; KEGG, K01955; Belongs to the CarB family. (1084 aa)
cobBHydrogenobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (434 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (448 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1354 aa)
guaAGlutamine-hydrolysing GMP synthase; Catalyzes the synthesis of GMP from XMP. (539 aa)
mesJCell cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (468 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa)
glnA-2COG0174: Glutamine synthetase, Ralstonia solanacearum; KEGG, K01915. (471 aa)
glnA-3COG0174: Glutamine synthetase, Caulobacter vibrioides; KEGG, K01915. (445 aa)
purDCOG0151: Phosphoribosylamine-glycine ligase, Ralstonia solanacearum; KEGG, K01945; Belongs to the GARS family. (425 aa)
nadENAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (566 aa)
panCPantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa)
dfpPhosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (398 aa)
purCCOG0152: Phosphoribosylaminoimidazolesuccinocarboxa mide (SAICAR) synthase, Ralstonia solanacearum; KEGG, K01923; Belongs to the SAICAR synthetase family. (296 aa)
gshBCOG0189: Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase), Ralstonia solanacearum; KEGG, K01920; Belongs to the prokaryotic GSH synthase family. (318 aa)
pncB-2Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (458 aa)
birACOG0340: Biotin-(acetyl-CoA carboxylase) ligase, Ralstonia solanacearum; KEGG, K01947. (307 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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