STRINGSTRING
merA merA pdhD-3 pdhD-3 pckA pckA ach1 ach1 gltA-2 gltA-2 BAG45728.1 BAG45728.1 sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC mdh mdh acnA acnA merA-2 merA-2 acnB acnB sdhC-2 sdhC-2 sucC sucC sucD sucD gltA gltA icd-2 icd-2 icd icd ftr1-2 ftr1-2 fumA fumA aceE aceE pdhC-2 pdhC-2 pdhD-2 pdhD-2 sdh sdh pdhC pdhC pdhD pdhD sucB sucB sucA sucA fumC fumC ftr1 ftr1 sdhB-4 sdhB-4 sdhB-3 sdhB-3 sdhB-2 sdhB-2 sdhA-2 sdhA-2 sdhD-2 sdhD-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
merAMercuric reductase; COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Agrobacterium tumefaciens strain C58; KEGG, K00520. (454 aa)
pdhD-3COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Vibrio cholerae; KEGG, K00382. (464 aa)
pckAGTP-dependent phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (621 aa)
ach1COG0427: Acetyl-CoA hydrolase, Caulobacter vibrioides; KEGG, K01067. (504 aa)
gltA-2COG0372: Citrate synthase, Ralstonia solanacearum; KEGG, K01647. (433 aa)
BAG45728.1COG2938: Uncharacterized conserved protein, Ralstonia solanacearum; KEGG, K09159. (90 aa)
sdhBCOG0479: Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit, Ralstonia solanacearum; KEGG, K00240. (233 aa)
sdhACOG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit, Ralstonia solanacearum; KEGG, K00239; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (591 aa)
sdhDCOG2142: Succinate dehydrogenase, hydrophobic anchor subunit, Ralstonia solanacearum; KEGG, K00242. (122 aa)
sdhCCOG2009: Succinate dehydrogenase/fumarate reductase, cytochrome b subunit, Ralstonia solanacearum; KEGG, K00241. (138 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
merA-2Mercuric reductase; COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00520. (459 aa)
acnBAconitate hydratase 2; COG1049: Aconitase B, Xylella fastidiosa 9a5c; KEGG, K01682; Belongs to the aconitase/IPM isomerase family. (861 aa)
sdhC-2COG2009: Succinate dehydrogenase/fumarate reductase, cytochrome b subunit, Ralstonia solanacearum; KEGG, K00241. (138 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
gltACOG0372: Citrate synthase, Agrobacterium tumefaciens strain C58. (410 aa)
icd-2COG0538: Isocitrate dehydrogenases, Ralstonia solanacearum; KEGG, K00031. (418 aa)
icdCOG2838: Monomeric isocitrate dehydrogenase, Xylella fastidiosa 9a5c; KEGG, K00031; Belongs to the monomeric-type IDH family. (741 aa)
ftr1-2High-affinity iron transporter; COG0672: High-affinity Fe2+/Pb2+ permease, Brucella melitensis; KEGG, K07243. (280 aa)
fumAClass I fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
aceEPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa)
pdhC-2Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (555 aa)
pdhD-2COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00382. (589 aa)
sdhCOG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit, Pseudomonas aeruginosa; KEGG, K00238. (579 aa)
pdhCPyruvate dehydrogenase E2 component; COG0596: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily), Pseudomonas aeruginosa; KEGG, K00627. (371 aa)
pdhDCOG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00382. (476 aa)
sucB2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (430 aa)
sucACOG0567: 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes, Ralstonia solanacearum; KEGG, K00164. (954 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
ftr1High-affinity iron transporter; COG0672: High-affinity Fe2+/Pb2+ permease, Rickettsia prowazekii; KEGG, K07243. (278 aa)
sdhB-4Succinate dehydrogenase iron-sulfur protein; COG2010: Cytochrome c, mono- and diheme variants, Pseudomonas aeruginosa; truncated cytochrome c oxidase subunit I. (236 aa)
sdhB-3COG0479: Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit, Ralstonia solanacearum; KEGG, K00240. (235 aa)
sdhB-2COG0479: Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit, Ralstonia solanacearum; KEGG, K00240. (233 aa)
sdhA-2COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit, Ralstonia solanacearum; KEGG, K00239. (591 aa)
sdhD-2COG2142: Succinate dehydrogenase, hydrophobic anchor subunit, Ralstonia solanacearum; KEGG, K00242. (122 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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