STRINGSTRING
fdhC-2 fdhC-2 gyaR-2 gyaR-2 BAG46272.1 BAG46272.1 fdh-4 fdh-4 pdhD-3 pdhD-3 BAG46599.1 BAG46599.1 gph-6 gph-6 glnA-4 glnA-4 acs-3 acs-3 purU-2 purU-2 acs acs pdhD pdhD BAG43634.1 BAG43634.1 phbB phbB atoB atoB gcl gcl gip gip garR garR fadA-3 fadA-3 glxK glxK garR-2 garR-2 ldcA ldcA BAG43918.1 BAG43918.1 aceA aceA glcB glcB BAG43991.1 BAG43991.1 BAG44022.1 BAG44022.1 pdhD-2 pdhD-2 glnA-2 glnA-2 glnA-3 glnA-3 hutG hutG acs-2 acs-2 BAG44111.1 BAG44111.1 gltA gltA kynB kynB phbB-2 phbB-2 atoB-2 atoB-2 purU purU gcvT gcvT gcvH gcvH gcvP gcvP ttuC ttuC merA merA acnB acnB merA-2 merA-2 ttuC-2 ttuC-2 BAG45666.1 BAG45666.1 acnA acnA mdh mdh gltA-2 gltA-2 fdh-2 fdh-2 fdhA-2 fdhA-2 fdhB fdhB gph-5 gph-5 acs-5 acs-5 atoB-4 atoB-4 atoB-3 atoB-3 fdh-6 fdh-6 fdh-5 fdh-5 BAG47653.1 BAG47653.1 arsC1-4 arsC1-4 arsC1-3 arsC1-3 phbB-4 phbB-4 BAG47527.1 BAG47527.1 BAG47499.1 BAG47499.1 phbB-3 phbB-3 acs-4 acs-4 ttuC-3 ttuC-3 arsC1-2 arsC1-2 glcB-2 glcB-2 gip-2 gip-2 serA-4 serA-4 glyA-2 glyA-2 BAG42045.1 BAG42045.1 glnA glnA serA-2 serA-2 gph gph eda-2 eda-2 glcD glcD glcD-2 glcD-2 glcD-3 glcD-3 glyA glyA BAG42645.1 BAG42645.1 fadA-2 fadA-2 fdsD fdsD fdhA fdhA BAG42829.1 BAG42829.1 fdhC fdhC arsC1 arsC1 gyaR gyaR gph-3 gph-3 katE katE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fdhC-2COG2864: Cytochrome b subunit of formate dehydrogenase, Pseudomonas aeruginosa; KEGG, K00127. (208 aa)
gyaR-2Glyoxylate reductase; COG1052: Lactate dehydrogenase and related dehydrogenases, Sinorhizobium meliloti; KEGG, K00015; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
BAG46272.1COG3665: Uncharacterized conserved protein, Schizosaccharomyces pombe. (286 aa)
fdh-4COG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Ralstonia solanacearum; KEGG, K00122; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (774 aa)
pdhD-3COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Vibrio cholerae; KEGG, K00382. (464 aa)
BAG46599.1Conserved hypothetical protein. (350 aa)
gph-6COG0546: Predicted phosphatases, Ralstonia solanacearum; KEGG, K01091. (207 aa)
glnA-4COG0174: Glutamine synthetase, Pseudomonas aeruginosa; KEGG, K01915. (448 aa)
acs-3COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Ralstonia solanacearum; KEGG, K01895. (568 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
acsCOG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Mesorhizobium loti; KEGG, K01895. (539 aa)
pdhDCOG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00382. (476 aa)
BAG43634.1Gluconate 2-dehydrogenase; COG1052: Lactate dehydrogenase and related dehydrogenases, Escherichia coli K12; KEGG, K00090; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
phbBacetoacetyl-CoA reductase; COG1028: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases), Ralstonia solanacearum; KEGG, K00023; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
atoBCOG0183: Acetyl-CoA acetyltransferase, Ralstonia solanacearum; KEGG, K00626; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
gclTartronate-semialdehyde synthase; COG3960: Glyoxylate carboligase, Pseudomonas aeruginosa; KEGG, K01608; Belongs to the TPP enzyme family. (591 aa)
gipCOG3622: Hydroxypyruvate isomerase, Ralstonia solanacearum; KEGG, K01816; Belongs to the hyi family. (269 aa)
garR2-hydroxy-3-oxopropionate reductase; COG2084: 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases, Mesorhizobium loti; KEGG, K00042. (296 aa)
fadA-3COG0183: Acetyl-CoA acetyltransferase, Ralstonia solanacearum; KEGG, K00632; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
glxKCOG1929: Glycerate kinase, Pseudomonas aeruginosa; KEGG, K00865; Belongs to the glycerate kinase type-1 family. (381 aa)
garR-22-hydroxy-3-oxopropionate reductase; COG2084: 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases, Pseudomonas aeruginosa; KEGG, K00042. (296 aa)
ldcAMuramoyltetrapeptide carboxypeptidase; COG1619: Uncharacterized proteins, homologs of microcin C7 resistance protein MccF, Salmonella typhimurium LT2; KEGG, K01297. (312 aa)
BAG43918.1Conserved hypothetical protein; COG1393: Arsenate reductase and related proteins, glutaredoxin family, Ralstonia solanacearum; Belongs to the ArsC family. (122 aa)
aceACOG2224: Isocitrate lyase, Ralstonia solanacearum; KEGG, K01637. (435 aa)
glcBCOG2225: Malate synthase, Ralstonia solanacearum; KEGG, K01638. (530 aa)
BAG43991.1COG2833: Uncharacterized protein conserved in bacteria, Ralstonia solanacearum. (285 aa)
BAG44022.1COG0247: Fe-S oxidoreductase, Ralstonia solanacearum; KEGG, K08263. (240 aa)
pdhD-2COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00382. (589 aa)
glnA-2COG0174: Glutamine synthetase, Ralstonia solanacearum; KEGG, K01915. (471 aa)
glnA-3COG0174: Glutamine synthetase, Caulobacter vibrioides; KEGG, K01915. (445 aa)
hutGCOG3741: N-formylglutamate amidohydrolase, Pseudomonas aeruginosa; KEGG, K01458. (265 aa)
acs-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
BAG44111.1COG2030: Acyl dehydratase, Ralstonia solanacearum. (158 aa)
gltACOG0372: Citrate synthase, Agrobacterium tumefaciens strain C58. (410 aa)
kynBN-formyl-L-kynurenine/ N-Formylanthranilate amidohydrolase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (213 aa)
phbB-2acetoacetyl-CoA reductase; COG1028: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases), Ralstonia solanacearum; KEGG, K00023. (247 aa)
atoB-2COG0183: Acetyl-CoA acetyltransferase, Ralstonia solanacearum; KEGG, K00626; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPGlycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
ttuCTartrate dehydrogenase; COG0473: Isocitrate/isopropylmalate dehydrogenase, Ralstonia solanacearum; KEGG, K00056. (361 aa)
merAMercuric reductase; COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Agrobacterium tumefaciens strain C58; KEGG, K00520. (454 aa)
acnBAconitate hydratase 2; COG1049: Aconitase B, Xylella fastidiosa 9a5c; KEGG, K01682; Belongs to the aconitase/IPM isomerase family. (861 aa)
merA-2Mercuric reductase; COG1249: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes, Ralstonia solanacearum; KEGG, K00520. (459 aa)
ttuC-2Tartrate dehydrogenase; COG0473: Isocitrate/isopropylmalate dehydrogenase, Ralstonia solanacearum; KEGG, K00056. (360 aa)
BAG45666.1Hypothetical protein. (131 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
gltA-2COG0372: Citrate synthase, Ralstonia solanacearum; KEGG, K01647. (433 aa)
fdh-2Formate dehydrogenase; KEGG, K00122. (196 aa)
fdhA-2Formate dehydrogenase alpha subunit; COG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Escherichia coli K12; KEGG, K00123; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (810 aa)
fdhBFormate dehydrogenase beta subunit; COG0437: Fe-S-cluster-containing hydrogenase components 1, Pseudomonas aeruginosa; KEGG, K00124. (304 aa)
gph-5COG0546: Predicted phosphatases, Sinorhizobium meliloti; KEGG, K01091. (224 aa)
acs-5COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Brucella melitensis; KEGG, K01895. (555 aa)
atoB-4COG0183: Acetyl-CoA acetyltransferase, Brucella melitensis; KEGG, K00626; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
atoB-3COG0183: Acetyl-CoA acetyltransferase, Ralstonia solanacearum; KEGG, K00626; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
fdh-6COG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Caulobacter vibrioides; KEGG, K00122; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
fdh-5Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (386 aa)
BAG47653.1Conserved hypothetical protein. (136 aa)
arsC1-4COG1393: Arsenate reductase and related proteins, glutaredoxin family, Mesorhizobium loti; KEGG, K00537. (140 aa)
arsC1-3COG1393: Arsenate reductase and related proteins, glutaredoxin family, Mesorhizobium loti; KEGG, K00537. (140 aa)
phbB-4acetoacetyl-CoA reductase; COG1028: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases), Ralstonia solanacearum; KEGG, K00023. (249 aa)
BAG47527.1COG0247: Fe-S oxidoreductase, Bacillus halodurans. (247 aa)
BAG47499.1COG0657: Esterase/lipase, Caulobacter vibrioides. (319 aa)
phbB-3acetoacetyl-CoA reductase; COG1028: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases), Ralstonia solanacearum; KEGG, K00023. (248 aa)
acs-4acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
ttuC-3Tartrate dehydrogenase; COG0473: Isocitrate/isopropylmalate dehydrogenase, Escherichia coli O157:H7; KEGG, K00056. (359 aa)
arsC1-2COG1393: Arsenate reductase and related proteins, glutaredoxin family, Vibrio cholerae; KEGG, K00537. (118 aa)
glcB-2Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa)
gip-2COG3622: Hydroxypyruvate isomerase, Ralstonia solanacearum; KEGG, K01816; Belongs to the hyi family. (258 aa)
serA-4COG1052: Lactate dehydrogenase and related dehydrogenases, Ralstonia solanacearum; KEGG, K00058; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (309 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
BAG42045.1Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (363 aa)
glnACOG0174: Glutamine synthetase, Caulobacter vibrioides; KEGG, K01915. (445 aa)
serA-2COG0111: Phosphoglycerate dehydrogenase and related dehydrogenases, Ralstonia solanacearum; KEGG, K00058. (313 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (256 aa)
eda-2COG0800: 2-keto-3-deoxy-6-phosphogluconate aldolase, Ralstonia solanacearum; KEGG, K01625. (208 aa)
glcD(S)-2-hydroxy-acid oxidase; COG0247: Fe-S oxidoreductase, Ralstonia solanacearum; KEGG, K00104. (408 aa)
glcD-2(S)-2-hydroxy-acid oxidase; COG0277: FAD/FMN-containing dehydrogenases, Ralstonia solanacearum; KEGG, K00104. (362 aa)
glcD-3(S)-2-hydroxy-acid oxidase; COG0277: FAD/FMN-containing dehydrogenases, Ralstonia solanacearum; KEGG, K00104. (497 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
BAG42645.1Aminotransferase; COG0075: Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase, Vibrio cholerae; KEGG, K00839. (403 aa)
fadA-2COG0183: Acetyl-CoA acetyltransferase, Sinorhizobium meliloti; KEGG, K00632; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
fdsDFormate dehydrogenase delta subunit; KEGG, K00126. (83 aa)
fdhAFormate dehydrogenase alpha subunit; COG3383: Uncharacterized anaerobic dehydrogenase, Sinorhizobium meliloti; KEGG, K00123. (983 aa)
BAG42829.1COG1894: NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit, Sinorhizobium meliloti; KEGG, K05903. (525 aa)
fdhCFormate dehydrogenase gamma subunit; COG1905: NADH:ubiquinone oxidoreductase 24 kD subunit, Sinorhizobium meliloti; KEGG, K00127. (166 aa)
arsC1COG1393: Arsenate reductase and related proteins, glutaredoxin family, Mesorhizobium loti; KEGG, K00537. (140 aa)
gyaRGlyoxylate reductase; COG1052: Lactate dehydrogenase and related dehydrogenases, Ralstonia solanacearum; KEGG, K00015; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
gph-3COG0546: Predicted phosphatases, Ralstonia solanacearum; KEGG, K01091. (219 aa)
katECatalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (701 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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