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gpm-2 gpm-2 serA serA fdh fdh BAG42446.1 BAG42446.1 gpm gpm BAG42515.1 BAG42515.1 glyA glyA BAG42633.1 BAG42633.1 BAG42645.1 BAG42645.1 fbp1 fbp1 fdsD fdsD fdhA fdhA BAG42829.1 BAG42829.1 fdhC fdhC serC serC BAG43172.1 BAG43172.1 acs acs BAG43616.1 BAG43616.1 serB serB ppsA ppsA BAG43991.1 BAG43991.1 eno eno acs-2 acs-2 ppc ppc BAG44457.1 BAG44457.1 adhC adhC fbaA fbaA BAG44515.1 BAG44515.1 fadH-2 fadH-2 serA-3 serA-3 mdh mdh fdh-2 fdh-2 fdhA-2 fdhA-2 fdhB fdhB fdhC-2 fdhC-2 pta pta fdh-4 fdh-4 acs-3 acs-3 BAG46780.1 BAG46780.1 BAG46783.1 BAG46783.1 BAG46813.1 BAG46813.1 fadH-3 fadH-3 glyA-2 glyA-2 fdhA2 fdhA2 BAG46833.1 BAG46833.1 BAG47117.1 BAG47117.1 dak1 dak1 acs-4 acs-4 ppsA-2 ppsA-2 ackA ackA ptb ptb fruK fruK BAG47580.1 BAG47580.1 ptb-2 ptb-2 ackA-2 ackA-2 adhC-3 adhC-3 fdh-5 fdh-5 fdh-6 fdh-6 acs-5 acs-5
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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gpm-2Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
serACOG0111: Phosphoglycerate dehydrogenase and related dehydrogenases, Ralstonia solanacearum; KEGG, K00058; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa)
fdhCOG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Ralstonia solanacearum; KEGG, K00122; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (691 aa)
BAG42446.1Conserved hypothetical protein. (352 aa)
gpmPhosphoglycerate mutase; COG0406: Fructose-2,6-bisphosphatase, Ralstonia solanacearum; KEGG, K01834. (220 aa)
BAG42515.1COG0069: Glutamate synthase domain 2, Ralstonia solanacearum; KEGG, K00264. (539 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
BAG42633.1Probable glutathione-dependent formaldehyde-activating protein; COG3791: Uncharacterized conserved protein, Pseudomonas aeruginosa. (136 aa)
BAG42645.1Aminotransferase; COG0075: Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase, Vibrio cholerae; KEGG, K00839. (403 aa)
fbp1COG0158: Fructose-1,6-bisphosphatase, Ralstonia solanacearum; KEGG, K03841. (337 aa)
fdsDFormate dehydrogenase delta subunit; KEGG, K00126. (83 aa)
fdhAFormate dehydrogenase alpha subunit; COG3383: Uncharacterized anaerobic dehydrogenase, Sinorhizobium meliloti; KEGG, K00123. (983 aa)
BAG42829.1COG1894: NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit, Sinorhizobium meliloti; KEGG, K05903. (525 aa)
fdhCFormate dehydrogenase gamma subunit; COG1905: NADH:ubiquinone oxidoreductase 24 kD subunit, Sinorhizobium meliloti; KEGG, K00127. (166 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa)
BAG43172.1Conserved hypothetical protein. (143 aa)
acsCOG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Mesorhizobium loti; KEGG, K01895. (539 aa)
BAG43616.1Probable glutathione-dependent formaldehyde-activating protein; COG3791: Uncharacterized conserved protein, Salmonella typhimurium LT2; GFA protein. (123 aa)
serBCOG0560: Phosphoserine phosphatase, Ralstonia solanacearum; KEGG, K01079. (281 aa)
ppsAATP:pyruvate, water phosphotransferase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa)
BAG43991.1COG2833: Uncharacterized protein conserved in bacteria, Ralstonia solanacearum. (285 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
acs-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1004 aa)
BAG44457.1Putative esterase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
adhCCOG1062: Zn-dependent alcohol dehydrogenases, class III, Ralstonia solanacearum; KEGG, K00121; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
fbaAClass II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
BAG44515.1Probable glutathione-dependent formaldehyde-activating protein; COG3791: Uncharacterized conserved protein, Ralstonia solanacearum. (115 aa)
fadH-2NADPH2-dependent 2,4-dienoyl-CoA reductase; COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family, Pseudomonas aeruginosa; KEGG, K00219. (677 aa)
serA-3COG0111: Phosphoglycerate dehydrogenase and related dehydrogenases, Agrobacterium tumefaciens strain C58; KEGG, K00058; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
fdh-2Formate dehydrogenase; KEGG, K00122. (196 aa)
fdhA-2Formate dehydrogenase alpha subunit; COG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Escherichia coli K12; KEGG, K00123; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (810 aa)
fdhBFormate dehydrogenase beta subunit; COG0437: Fe-S-cluster-containing hydrogenase components 1, Pseudomonas aeruginosa; KEGG, K00124. (304 aa)
fdhC-2COG2864: Cytochrome b subunit of formate dehydrogenase, Pseudomonas aeruginosa; KEGG, K00127. (208 aa)
ptaPhosphate acetyltransferase; COG0280: Phosphotransacetylase, Sinorhizobium meliloti; KEGG, K00625. (344 aa)
fdh-4COG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Ralstonia solanacearum; KEGG, K00122; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (774 aa)
acs-3COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Ralstonia solanacearum; KEGG, K01895. (568 aa)
BAG46780.1Amine dehydrogenase; KEGG, K08685; Belongs to the aromatic amine dehydrogenase light chain family. (181 aa)
BAG46783.1Amine dehydrogenase; KEGG, K08685. (385 aa)
BAG46813.1COG0247: Fe-S oxidoreductase, Ralstonia solanacearum; KEGG, K08263. (641 aa)
fadH-3NADPH2-dependent 2,4-dienoyl-CoA reductase; COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family, Ralstonia solanacearum; KEGG, K00219. (687 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
fdhA2Glutathione-independent formaldehyde dehydrogenase; COG1063: Threonine dehydrogenase and related Zn-dependent dehydrogenases, Ralstonia solanacearum; KEGG, K00148. (398 aa)
BAG46833.1COG0627: Predicted esterase, Pasteurella multocida. (292 aa)
BAG47117.1Conserved hypothetical protein; COG2879: Uncharacterized small protein, Ralstonia solanacearum. (68 aa)
dak1Dihydroxyacetone kinase; Inactivated permease of the major facilitator superfamily. (566 aa)
acs-4acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
ppsA-2Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (803 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
ptbPhosphate butyryltransferase; COG0280: Phosphotransacetylase, Rickettsia prowazekii; KEGG, K00634. (343 aa)
fruK1-phosphofructokinase; COG1105: Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB), Mycobacterium tuberculosis CDC1551; KEGG, K00882; Belongs to the carbohydrate kinase PfkB family. (311 aa)
BAG47580.1Hypothetical protein. (162 aa)
ptb-2Phosphate butyryltransferase; COG0280: Phosphotransacetylase, Rickettsia prowazekii; KEGG, K00634. (313 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (392 aa)
adhC-3COG1062: Zn-dependent alcohol dehydrogenases, class III, Escherichia coli O157:H7; KEGG, K00121; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
fdh-5Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (386 aa)
fdh-6COG0243: Anaerobic dehydrogenases, typically selenocysteine-containing, Caulobacter vibrioides; KEGG, K00122; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
acs-5COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, Brucella melitensis; KEGG, K01895. (555 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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