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iorA-2 iorA-2 BAG43274.1 BAG43274.1 BAG43229.1 BAG43229.1 coxL-3 coxL-3 iorA iorA BAG43094.1 BAG43094.1 coxL-2 coxL-2 coxS coxS pncB pncB lolA lolA BAG42741.1 BAG42741.1 BAG42670.1 BAG42670.1 nadK nadK pntB pntB pntA-2 pntA-2 pntA pntA cinA cinA nahG-3 nahG-3 BAG46260.1 BAG46260.1 coxL-5 coxL-5 iorA-4 iorA-4 gabD gabD iorB-2 iorB-2 iorA-3 iorA-3 BAG46077.1 BAG46077.1 BAG46015.1 BAG46015.1 cccA-2 cccA-2 gabD-3 gabD-3 coxL-4 coxL-4 cobB-2 cobB-2 BAG45633.1 BAG45633.1 nadC-2 nadC-2 BAG45558.1 BAG45558.1 BAG45372.1 BAG45372.1 BAG45199.1 BAG45199.1 surE-2 surE-2 nadA nadA nadC nadC nadB nadB nadE nadE rsfS rsfS nadD nadD BAG44041.1 BAG44041.1 pncA pncA BAG43731.1 BAG43731.1 surE surE BAG43588.1 BAG43588.1 iorB iorB BAG43310.1 BAG43310.1 BAG47219.1 BAG47219.1 BAG47307.1 BAG47307.1 gabD-5 gabD-5 coxS-2 coxS-2 nahG nahG maiA-2 maiA-2 BAG45820.1 BAG45820.1 BAG45819.1 BAG45819.1 pncB-2 pncB-2 BAG47524.1 BAG47524.1 nadE-2 nadE-2 iorA-6 iorA-6 iorB-4 iorB-4 BAG46696.1 BAG46696.1 iorB-3 iorB-3 iorA-5 iorA-5 BAG46416.1 BAG46416.1 BAG46379.1 BAG46379.1 nadX nadX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
iorA-2Isoquinoline 1-oxidoreductase, alpha subunit; COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Ralstonia solanacearum; KEGG, K07302. (155 aa)
BAG43274.1COG1051: ADP-ribose pyrophosphatase, Ralstonia solanacearum. (178 aa)
BAG43229.1Putative exported protein. (259 aa)
coxL-3COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Pseudomonas aeruginosa; CoxL protein. (773 aa)
iorAIsoquinoline 1-oxidoreductase, alpha subunit; COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Ralstonia solanacearum; KEGG, K07302. (153 aa)
BAG43094.1COG1289: Predicted membrane protein, Ralstonia solanacearum. (763 aa)
coxL-2COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Pseudomonas aeruginosa; CoxL protein. (727 aa)
coxSCOG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Ralstonia solanacearum; CoxS protein. (146 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (399 aa)
lolAOuter membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (229 aa)
BAG42741.1COG0846: NAD-dependent protein deacetylases, SIR2 family, Aquifex aeolicus. (290 aa)
BAG42670.1Conserved hypothetical protein. (210 aa)
nadKNAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (300 aa)
pntBNAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (484 aa)
pntA-2COG3288: NAD/NADP transhydrogenase alpha subunit, Ralstonia solanacearum; KEGG, K00324. (108 aa)
pntACOG3288: NAD/NADP transhydrogenase alpha subunit, Ralstonia solanacearum; KEGG, K00324. (379 aa)
cinAC-terminal domain; COG1546: Uncharacterized protein (competence- and mitomycin-induced), Ralstonia solanacearum; CinA protein; KEGG, K03743; Belongs to the CinA family. (166 aa)
nahG-3Salicylate hydroxylase; COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases, Agrobacterium tumefaciens strain C58; KEGG, K00480. (404 aa)
BAG46260.1NUDIX hydrolase. (161 aa)
coxL-5COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Ralstonia solanacearum; CoxL protein. (827 aa)
iorA-4Isoquinoline 1-oxidoreductase, alpha subunit; COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Ralstonia solanacearum; KEGG, K07302. (152 aa)
gabDNADP-dependent succinate-semialdehyde dehydrogenase; COG1012: NAD-dependent aldehyde dehydrogenases, Agrobacterium tumefaciens strain C58; KEGG, K00135. (481 aa)
iorB-2Isoquinoline 1-oxidoreductase, beta subunit; COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Pseudomonas aeruginosa; KEGG, K00256. (739 aa)
iorA-3Isoquinoline 1-oxidoreductase, alpha subunit; COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Ralstonia solanacearum; KEGG, K07302. (151 aa)
BAG46077.1Putative fusaric acid resistance protein; COG1289: Predicted membrane protein, Pseudomonas aeruginosa. (682 aa)
BAG46015.1Conserved hypothetical protein. (453 aa)
cccA-2COG2010: Cytochrome c, mono- and diheme variants, Pseudomonas aeruginosa. (831 aa)
gabD-3NADP-dependent succinate-semialdehyde dehydrogenase; COG1012: NAD-dependent aldehyde dehydrogenases, Pseudomonas aeruginosa; KEGG, K00135; Belongs to the aldehyde dehydrogenase family. (489 aa)
coxL-4COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Pseudomonas aeruginosa; CoxL protein. (763 aa)
cobB-2SIR2 family NAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. (297 aa)
BAG45633.1Hypothetical protein. (256 aa)
nadC-2COG0157: Nicotinate-nucleotide pyrophosphorylase, Ralstonia solanacearum; KEGG, K00767; Belongs to the NadC/ModD family. (278 aa)
BAG45558.1COG1683: Uncharacterized conserved protein, Agrobacterium tumefaciens strain C58. (163 aa)
BAG45372.1COG1289: Predicted membrane protein, Ralstonia solanacearum. (356 aa)
BAG45199.1Putative extracellular endonuclease/exonuclease/phosphatase; COG2374: Predicted extracellular nuclease, Pseudomonas aeruginosa; KEGG, K07004. (603 aa)
surE-25'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (259 aa)
nadAQuinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (378 aa)
nadCCOG0157: Nicotinate-nucleotide pyrophosphorylase, Ralstonia solanacearum; KEGG, K00767; Belongs to the NadC/ModD family. (293 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (528 aa)
nadENAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (566 aa)
rsfSIojap domain protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (149 aa)
nadDCOG1057: Nicotinic acid mononucleotide adenylyltransferase, Ralstonia solanacearum; KEGG, K00969; Belongs to the NadD family. (196 aa)
BAG44041.1Molybdopterin-binding protein; COG1058: Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA, Ralstonia solanacearum. (272 aa)
pncANicotinamidase; COG1335: Amidases related to nicotinamidase, Ralstonia solanacearum; KEGG, K01440. (210 aa)
BAG43731.1ATP-NAD/AcoX kinase; COG3199: Uncharacterized conserved protein, Pseudomonas aeruginosa. (352 aa)
surE5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
BAG43588.1Putative NUDIX hydrolase; Belongs to the Nudix hydrolase family. (137 aa)
iorBIsoquinoline 1-oxidoreductase, beta subunit; COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Ralstonia solanacearum; KEGG, K07303. (765 aa)
BAG43310.1Putative fusaric acid resistance protein; COG1289: Predicted membrane protein, Pseudomonas aeruginosa. (733 aa)
BAG47219.1Putative fusaric acid resistance efflux transporter permease protein; COG1289: Predicted membrane protein, Brucella melitensis. (710 aa)
BAG47307.1Amidohydrolase-like protein; COG1574: Predicted metal-dependent hydrolase with the TIM-barrel fold, Mycobacterium tuberculosis CDC1551; KEGG, K07047. (555 aa)
gabD-5NADP-dependent succinate-semialdehyde dehydrogenase; COG1012: NAD-dependent aldehyde dehydrogenases, Pseudomonas aeruginosa; KEGG, K00135; Belongs to the aldehyde dehydrogenase family. (486 aa)
coxS-2COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Pseudomonas aeruginosa; CoxS protein. (167 aa)
nahGSalicylate hydroxylase; COG0654: 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases, Salmonella typhimurium LT2; KEGG, K00480. (385 aa)
maiA-2Maleate isomerase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. (250 aa)
BAG45820.1Predicted hydrolase or acyltransferase. (276 aa)
BAG45819.1Putative leucyl aminopeptidase. (346 aa)
pncB-2Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (458 aa)
BAG47524.1Predicted membrane protein. (659 aa)
nadE-2NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (292 aa)
iorA-6Isoquinoline 1-oxidoreductase, alpha subunit; COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Caulobacter vibrioides; KEGG, K00256. (164 aa)
iorB-4Isoquinoline 1-oxidoreductase, beta subunit; COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Pseudomonas aeruginosa; KEGG, K07303. (749 aa)
BAG46696.1YcaC-related amidohydrolase; COG1335: Amidases related to nicotinamidase, Ralstonia solanacearum. (212 aa)
iorB-3Isoquinoline 1-oxidoreductase, beta subunit; COG1529: Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs, Pseudomonas aeruginosa; KEGG, K07303. (738 aa)
iorA-5Isoquinoline 1-oxidoreductase, alpha subunit; COG2080: Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs, Pseudomonas aeruginosa; KEGG, K07302. (153 aa)
BAG46416.1Cysteine hydrolase; COG1335: Amidases related to nicotinamidase, Bacillus subtilis. (203 aa)
BAG46379.1Putative fusaric acid resistance protein; COG1289: Predicted membrane protein, Yersinia pestis. (720 aa)
nadXAspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (276 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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