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calB-2 calB-2 gltD-2 gltD-2 pyrD-2 pyrD-2 dpyS dpyS BAG47609.1 BAG47609.1 BAG47345.1 BAG47345.1 BAG47288.1 BAG47288.1 apbA-6 apbA-6 apbA-5 apbA-5 BAG46909.1 BAG46909.1 coaA coaA apbA-4 apbA-4 stbC stbC BAG46363.1 BAG46363.1 ilvC ilvC BAG43657.1 BAG43657.1 apbA-2 apbA-2 calB calB yacG yacG acpT acpT coaE coaE panB panB BAG42726.1 BAG42726.1 BAG42745.1 BAG42745.1 BAG42873.1 BAG42873.1 acpS acpS apbA apbA ilvD-3 ilvD-3 BAG45605.1 BAG45605.1 ilvB-3 ilvB-3 ilvB-2 ilvB-2 cutA cutA baf baf coaD coaD ilvE ilvE apbA-3 apbA-3 dfp dfp ilvD ilvD panD panD panC panC BAG44278.1 BAG44278.1 ilvB ilvB ilvH ilvH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
calB-2COG1012: NAD-dependent aldehyde dehydrogenases, Pseudomonas aeruginosa; KEGG, K00154; Belongs to the aldehyde dehydrogenase family. (475 aa)
gltD-2COG0493: NADPH-dependent glutamate synthase beta chain and related oxidoreductases, Brucella melitensis; KEGG, K00266. (445 aa)
pyrD-2COG0167: Dihydroorotate dehydrogenase, Mesorhizobium loti; KEGG, K00226. (435 aa)
dpySDihydropyrimidinase; COG0044: Dihydroorotase and related cyclic amidohydrolases, Pseudomonas aeruginosa; KEGG, K01464. (485 aa)
BAG47609.1Hypothetical protein. (272 aa)
BAG47345.1COG1012: NAD-dependent aldehyde dehydrogenases, Mesorhizobium loti; KEGG, K00128. (474 aa)
BAG47288.1COG1012: NAD-dependent aldehyde dehydrogenases, Bacillus halodurans; KEGG, K00128. (488 aa)
apbA-62-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (298 aa)
apbA-52-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (316 aa)
BAG46909.1COG1012: NAD-dependent aldehyde dehydrogenases, Ralstonia solanacearum; KEGG, K00128. (503 aa)
coaACOG1072: Panthothenate kinase, Sinorhizobium meliloti; KEGG, K00867. (217 aa)
apbA-42-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (312 aa)
stbCPlasmid stability protein-like protein. (79 aa)
BAG46363.1Acetolactate synthase; COG0028: Thiamine pyrophosphate-requiring enzymes; KEGG, K01651; Belongs to the TPP enzyme family. (555 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
BAG43657.1COG1012: NAD-dependent aldehyde dehydrogenases, Ralstonia solanacearum; KEGG, K00128. (478 aa)
apbA-22-dehydropantoate 2-reductase; COG1893: Ketopantoate reductase, Ralstonia solanacearum; KEGG, K00077. (332 aa)
calBCOG1012: NAD-dependent aldehyde dehydrogenases, Pseudomonas aeruginosa; KEGG, K00154; Belongs to the aldehyde dehydrogenase family. (480 aa)
yacGConserved hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (65 aa)
acpT4'-phosphopantetheinyl transferase; Frame shift-inactivated ABC amino acid transporter periplasmic ligand-binding protein; Belongs to the P-Pant transferase superfamily. (251 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
BAG42726.1Tyrosine recombinase; COG0582: Integrase, Escherichia coli O157:H7. (651 aa)
BAG42745.1COG5495: Uncharacterized conserved protein, Ralstonia solanacearum. (309 aa)
BAG42873.1Gene 32 protein. (275 aa)
acpSHolo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (146 aa)
apbA2-dehydropantoate 2-reductase; COG1893: Ketopantoate reductase, Staphylococcus aureus N315; KEGG, K00077. (351 aa)
ilvD-3Dihydroxy-acid dehydratase; Inactivated hypothetical protein; Belongs to the IlvD/Edd family. (619 aa)
BAG45605.1COG1012: NAD-dependent aldehyde dehydrogenases, Pseudomonas aeruginosa; Belongs to the aldehyde dehydrogenase family. (495 aa)
ilvB-3Acetolactate synthase large subunit; COG0028: Thiamine pyrophosphate-requiring enzymes; KEGG, K01652; Belongs to the TPP enzyme family. (546 aa)
ilvB-2Acetolactate synthase large subunit; COG0028: Thiamine pyrophosphate-requiring enzymes; KEGG, K01652; Belongs to the TPP enzyme family. (567 aa)
cutAPeriplasmic divalent cation tolerance protein; KEGG, K03926. (108 aa)
bafPutative transcriptional regulator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (262 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
apbA-32-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa)
dfpPhosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
ilvDCOG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase, Ralstonia solanacearum; KEGG, K01687; Belongs to the IlvD/Edd family. (557 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa)
panCPantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa)
BAG44278.1COG1012: NAD-dependent aldehyde dehydrogenases, Ralstonia solanacearum; KEGG, K00128. (479 aa)
ilvBAcetolactate synthase large subunit; COG0028: Thiamine pyrophosphate-requiring enzymes; KEGG, K01652. (587 aa)
ilvHCOG0440: Acetolactate synthase, small (regulatory) subunit, Ralstonia solanacearum; KEGG, K01653. (163 aa)
Your Current Organism:
Burkholderia multivorans
NCBI taxonomy Id: 395019
Other names: B. multivorans ATCC 17616, Burkholderia multivorans ATCC 17616, Burkholderia multivorans str. ATCC 17616, Burkholderia multivorans strain ATCC 17616
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