STRINGSTRING
Lcho_0346 Lcho_0346 Lcho_0422 Lcho_0422 rppH rppH rne rne Lcho_0617 Lcho_0617 Lcho_0704 Lcho_0704 rph rph Lcho_0708 Lcho_0708 pnp pnp xseB xseB Lcho_4365 Lcho_4365 Lcho_3983 Lcho_3983 Lcho_3778 Lcho_3778 Lcho_3399 Lcho_3399 surE surE rnhA rnhA Lcho_2318 Lcho_2318 Lcho_2527 Lcho_2527 xseA xseA dut dut rhlE rhlE rnhB rnhB Lcho_2963 Lcho_2963 Lcho_2997 Lcho_2997 Lcho_3013 Lcho_3013 Lcho_3171 Lcho_3171 Lcho_3214 Lcho_3214 Lcho_3215 Lcho_3215 Lcho_0014 Lcho_0014 Lcho_0190 Lcho_0190
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Lcho_0346KEGG: mpt:Mpe_A0279 hypothetical protein. (850 aa)
Lcho_0422Adenosylhomocysteine nucleosidase; PFAM: purine or other phosphorylase family 1; KEGG: mpt:Mpe_A3574 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. (258 aa)
rppHNUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (203 aa)
rneRibonuclease, Rne/Rng family; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1058 aa)
Lcho_0617PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: mpt:Mpe_A0631 putative ATP-dependent RNA helicase 2; Belongs to the DEAD box helicase family. (479 aa)
Lcho_0704Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (212 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (241 aa)
Lcho_0708PFAM: YicC domain protein; domain of unknown function DUF1732; KEGG: mpt:Mpe_A2708 hypothetical protein. (302 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (767 aa)
xseBExodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (81 aa)
Lcho_4365PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: cvi:CV_2841 ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (417 aa)
Lcho_3983KEGG: mpt:Mpe_A3203 hypothetical protein. (208 aa)
Lcho_3778PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mpt:Mpe_A2432 putative sulfur oxidation signal peptide protein; Belongs to the 5'-nucleotidase family. (580 aa)
Lcho_3399KEGG: aav:Aave_1004 putative deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; Belongs to the dGTPase family. Type 2 subfamily. (381 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (160 aa)
Lcho_2318Hypothetical protein. (178 aa)
Lcho_2527PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: mfa:Mfla_1258 DEAD/DEAH box helicase-like protein; Belongs to the DEAD box helicase family. (502 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (432 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa)
rhlEDEAD/DEAH box helicase domain protein; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (479 aa)
rnhBRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (218 aa)
Lcho_2963TIGRFAM: addiction module toxin, Txe/YoeB family; PFAM: Addiction module toxin Txe/YoeB; KEGG: eba:ebD102 hypothetical protein. (82 aa)
Lcho_2997PFAM: helicase domain protein; DbpA RNA-binding domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: bxe:Bxe_A4436 ATP-dependent RNA helicase DbpA; Belongs to the DEAD box helicase family. (477 aa)
Lcho_3013PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpa:RPA0955 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. (557 aa)
Lcho_3171KEGG: eba:ebB86 RelE-like cytotoxic translational repressor of toxin-antitoxin stability system. (111 aa)
Lcho_3214PFAM: 5'-Nucleotidase domain protein; KEGG: sde:Sde_0580 alkaline phosphatase; Belongs to the 5'-nucleotidase family. (668 aa)
Lcho_3215KEGG: maq:Maqu_3484 hypothetical protein. (576 aa)
Lcho_0014KEGG: ajs:Ajs_0603 MazG nucleotide pyrophosphohydrolase. (126 aa)
Lcho_0190PFAM: beta-lactamase domain protein; KEGG: mpt:Mpe_A0066 cAMP phosphodiesterases, class-II, metallo-beta-lactamase superfamily. (258 aa)
Your Current Organism:
Leptothrix cholodnii
NCBI taxonomy Id: 395495
Other names: L. cholodnii SP-6, Leptothrix cholodnii SP-6, Leptothrix cholodnii str. SP-6, Leptothrix cholodnii strain SP-6
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