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| | mltF | Membrane-bound lytic murein transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (486 aa) |
| | ppc | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (876 aa) |
| | SED17722.1 | 2-Methylisocitrate lyase, PEP mutase family. (273 aa) |
| | SED18160.1 | tRNA A37 threonylcarbamoyladenosine dehydratase. (272 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | SED22252.1 | 3-carboxy-cis,cis-muconate cycloisomerase. (454 aa) |
| | SED23508.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (295 aa) |
| | SED24110.1 | Uncharacterized conserved protein; Manually curated. (134 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | SED27500.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (324 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa) |
| | SED29481.1 | Aminodeoxychorismate lyase apoprotein. (271 aa) |
| | mltG | UPF0755 protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (400 aa) |
| | SED29710.1 | Cyclic pyranopterin phosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (322 aa) |
| | SED30284.1 | 2-keto-3-deoxy-phosphogalactonate aldolase. (206 aa) |
| | fumC | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | SED34375.1 | Chorismate mutase. (364 aa) |
| | SED34687.1 | dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (358 aa) |
| | SED35060.1 | 3-hydroxybutyryl-CoA dehydratase. (155 aa) |
| | SED36108.1 | Membrane-bound lytic murein transglycosylase MltF; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (473 aa) |
| | SED36217.1 | Deoxyribodipyrimidine photolyase-related protein. (512 aa) |
| | SED39055.1 | Protein of unknown function. (600 aa) |
| | SED40736.1 | ADP-ribosyl-[dinitrogen reductase] hydrolase. (132 aa) |
| | SED42638.1 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (118 aa) |
| | SED43513.1 | Porphobilinogen synthase; Belongs to the ALAD family. (324 aa) |
| | SED44015.1 | D-glucarate dehydratase. (447 aa) |
| | SED46424.1 | hydroxymethylglutaryl-CoA lyase. (299 aa) |
| | SED47873.1 | Isocitrate lyase. (441 aa) |
| | SED48022.1 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | cysG | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (464 aa) |
| | SED50367.1 | Surfactin synthase thioesterase subunit. (233 aa) |
| | SED50424.1 | Uncharacterized conserved protein; Manually curated. (133 aa) |
| | SED51486.1 | Isochorismate pyruvate lyase. (106 aa) |
| | SED52167.1 | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (219 aa) |
| | ribB-2 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (369 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (560 aa) |
| | SED54240.1 | Cystathionine gamma-lyase. (392 aa) |
| | SED54270.1 | Cystathionine beta-synthase. (458 aa) |
| | moaA | Cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (332 aa) |
| | menB | 1,4-Dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (260 aa) |
| | SED58818.1 | 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (286 aa) |
| | SED62749.1 | Aconitate hydratase 2 / 2-methylisocitrate dehydratase. (99 aa) |
| | SED62883.1 | Predicted metal-dependent hydrolase, TIM-barrel fold. (441 aa) |
| | SED63064.1 | Acyl dehydratase. (158 aa) |
| | SED63099.1 | NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (300 aa) |
| | SED63173.1 | N-terminal half of MaoC dehydratase. (283 aa) |
| | SED63241.1 | Acyl dehydratase. (289 aa) |
| | SED63528.1 | Hypothetical protein. (123 aa) |
| | SED63773.1 | Predicted metal-dependent hydrolase, TIM-barrel fold. (396 aa) |
| | SED64389.1 | Acyl dehydratase. (286 aa) |
| | SED64638.1 | enoyl-CoA hydratase. (264 aa) |
| | SED64703.1 | Enoyl-CoA hydratase/carnithine racemase. (259 aa) |
| | SED65452.1 | Uncharacterized OB-fold protein, contains Zn-ribbon domain. (135 aa) |
| | SED65730.1 | crotonobetainyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa) |
| | SED66328.1 | Aconitase; Belongs to the aconitase/IPM isomerase family. (866 aa) |
| | SED66460.1 | Uncharacterized conserved protein. (160 aa) |
| | SED67485.1 | Ornithine decarboxylase. (751 aa) |
| | SED67971.1 | L-arabinonate dehydratase; Belongs to the IlvD/Edd family. (578 aa) |
| | gmd | GDPmannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (348 aa) |
| | ilvA-2 | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (337 aa) |
| | SEB59359.1 | Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase. (791 aa) |
| | SEB60024.1 | 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase. (262 aa) |
| | SEB60076.1 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (336 aa) |
| | SEB60666.1 | Hypothetical protein. (324 aa) |
| | SEB60728.1 | MaoC like domain-containing protein. (139 aa) |
| | SEB61277.1 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (342 aa) |
| | SEB61334.1 | 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase. (263 aa) |
| | arnA | UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (663 aa) |
| | SEB66047.1 | Deferrochelatase/peroxidase EfeB; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (431 aa) |
| | SEB67421.1 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (173 aa) |
| | SEB68403.1 | Citrate lyase subunit beta / citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (296 aa) |
| | SEB68436.1 | Diaminopimelate decarboxylase. (464 aa) |
| | SEB69425.1 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa) |
| | SEB71326.1 | Class II Aldolase and Adducin N-terminal domain-containing protein. (224 aa) |
| | SEB71437.1 | Class II Aldolase and Adducin N-terminal domain-containing protein. (244 aa) |
| | SEB72193.1 | 5-carboxy-2-oxohept-3-enedioate decarboxylase HpaG1 subunit. (219 aa) |
| | SEB72226.1 | 5-carboxy-2-oxohept-3-enedioate decarboxylase HpaG2 subunit. (256 aa) |
| | SEB72414.1 | 2-oxo-hept-3-ene-1,7-dioate hydratase. (267 aa) |
| | SEB72454.1 | 2,4-dihydroxyhept-2-enedioate aldolase; Belongs to the HpcH/HpaI aldolase family. (266 aa) |
| | SEB73785.1 | D-serine deaminase, pyridoxal phosphate-dependent. (405 aa) |
| | SEB75235.1 | Strictosidine synthase. (362 aa) |
| | SEB77433.1 | L-alanine-DL-glutamate epimerase. (368 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | SEB80438.1 | Hypothetical protein. (311 aa) |
| | SEB80932.1 | L-serine/L-threonine ammonia-lyase. (304 aa) |
| | SEB81342.1 | Ureidoglycolate lyase. (282 aa) |
| | SEB81550.1 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (595 aa) |
| | SEB82314.1 | Threonine dehydratase. (318 aa) |
| | SEB83219.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (305 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | SEB87345.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (293 aa) |
| | SEB88041.1 | Threonine synthase. (459 aa) |
| | SEB88151.1 | Cystathionine gamma-synthase. (425 aa) |
| | SEB91919.1 | Carboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (289 aa) |
| | SEB92249.1 | Putative intracellular protease/amidase. (225 aa) |
| | SEB92325.1 | Predicted secreted hydrolase. (357 aa) |
| | cynS | Cyanate lyase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (155 aa) |
| | SEB95200.1 | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (220 aa) |
| | SEC03405.1 | Carbonic anhydrase. (250 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa) |
| | fadB | Short chain enoyl-CoA hydratase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa) |
| | SEC07455.1 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa) |
| | SEC09526.1 | Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions. (163 aa) |
| | SEC09684.1 | 2-methylcitrate dehydratase. (494 aa) |
| | SEC09758.1 | Aconitase /2-methylcitrate dehydratase (trans-methylaconitate-forming). (864 aa) |
| | prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (297 aa) |
| | SEC10921.1 | Short chain enoyl-CoA hydratase. (714 aa) |
| | mtnB | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (208 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | SEC12238.1 | OHCU decarboxylase. (171 aa) |
| | allA | Ureidoglycolate lyase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source. (167 aa) |
| | SEC14458.1 | L-threonine O-3-phosphate decarboxylase. (330 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (302 aa) |
| | SEC16396.1 | Tartronate-semialdehyde synthase; Belongs to the TPP enzyme family. (591 aa) |
| | SEC20403.1 | Pterin-4-alpha-carbinolamine dehydratase. (118 aa) |
| | fabA | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa) |
| | SEC24529.1 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa) |
| | SEC26917.1 | L-threonine aldolase. (334 aa) |
| | SEC30624.1 | Acyl dehydratase. (156 aa) |
| | SEC30974.1 | 2-keto-3-deoxy-phosphogluconate aldolase. (221 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (229 aa) |
| | SEC32139.1 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa) |
| | SEC34813.1 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa) |
| | nth | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa) |
| | SEC37934.1 | Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (156 aa) |
| | SEC38372.1 | L-threonine synthase. (469 aa) |
| | moaC | Cyclic pyranopterin monophosphate synthase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (157 aa) |
| | algL | poly(beta-D-mannuronate) lyase; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism; Belongs to the polysaccharide lyase 5 family. (373 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (341 aa) |
| | SEC44254.1 | Deoxyribodipyrimidine photo-lyase type I. (481 aa) |
| | mhpD | 2-keto-4-pentenoate hydratase; Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. Belongs to the hydratase/decarboxylase family. MhpD subfamily. (268 aa) |
| | SEC45293.1 | 4-hydroxy-2-oxovalerate aldolase. (336 aa) |
| | SEC45858.1 | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (214 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (637 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | nnrE | NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] (499 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (286 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (629 aa) |
| | SEC57167.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (559 aa) |
| | SEC57286.1 | Histidine ammonia-lyase. (514 aa) |
| | SEC57643.1 | Predicted 3-hydroxylacyl-ACP dehydratase, HotDog domain. (157 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa) |
| | hutH | Histidine ammonia-lyase. (510 aa) |
| | SEC60486.1 | Histidine ammonia-lyase. (507 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (562 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | SEC69334.1 | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (243 aa) |
| | SEC71229.1 | Uncharacterized conserved protein. (133 aa) |
| | SEC76032.1 | Pyruvate carboxylase subunit B. (602 aa) |
| | SEC76628.1 | Aspartate ammonia-lyase. (474 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa) |
| | ubiC | Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (187 aa) |
| | SEC78436.1 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa) |
| | SEC79736.1 | Secondary thiamine-phosphate synthase enzyme. (141 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa) |
| | SEC80136.1 | Adenylate cyclase. (948 aa) |
| | argH | Argininosuccinate lyase. (464 aa) |
| | SEC80420.1 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (255 aa) |
| | SEC80912.1 | Enhancing lycopene biosynthesis protein 2; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (222 aa) |
| | SEC81017.1 | Porphobilinogen synthase; Belongs to the ALAD family. (337 aa) |
| | ubiD | 3-octaprenyl-4hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (488 aa) |
| | SEC81496.1 | Cation transport protein ChaC; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (613 aa) |
| | mutM | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (270 aa) |
| | SEC87926.1 | Membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (394 aa) |
| | SEC88331.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | SEC89226.1 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | SEC90169.1 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa) |
| | SEC92555.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (493 aa) |
| | SEC93445.1 | Anthranilate synthase, component II. (197 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (278 aa) |
| | speD | Adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (363 aa) |
| | eutC | Ethanolamine ammonia-lyase light chain; Belongs to the EutC family. (274 aa) |
| | SEC97573.1 | Ethanolamine ammonia-lyase heavy chain. (464 aa) |
| | ubiX | 4-hydroxy-3-polyprenylbenzoate decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (210 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (335 aa) |
| | SED00374.1 | 4-hydroxyphenylpyruvate dioxygenase. (633 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | SED00952.1 | ferredoxin--NADP+ reductase. (258 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | SED07107.1 | Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (387 aa) |
| | SED07777.1 | 5-dehydro-4-deoxyglucarate dehydratase; Belongs to the DapA family. (303 aa) |
| | SED07882.1 | Galactarate dehydratase. (517 aa) |
| | rlpA-2 | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (124 aa) |
| | SED09732.1 | D-erythro-7,8-dihydroneopterin triphosphate epimerase. (126 aa) |
