STRINGSTRING
asd asd ACL47419.1 ACL47419.1 ACL47333.1 ACL47333.1 ACL47331.1 ACL47331.1 ACL47275.1 ACL47275.1 ACL47235.1 ACL47235.1 gshB gshB ACL47095.1 ACL47095.1 lipA-2 lipA-2 ACL46867.1 ACL46867.1 ACL46790.1 ACL46790.1 lipA lipA ACL46590.1 ACL46590.1 ACL46575.1 ACL46575.1 metK metK dxs dxs ACL46232.1 ACL46232.1 ACL46215.1 ACL46215.1 acsA acsA accD accD mtnA mtnA mtnP mtnP ACL45826.1 ACL45826.1 cysC cysC thiC thiC ACL45203.1 ACL45203.1 metXA metXA ACL45196.1 ACL45196.1 ACL44905.1 ACL44905.1 ACL44879.1 ACL44879.1 thiE thiE ackA ackA ACL44521.1 ACL44521.1 thiG thiG ACL43911.1 ACL43911.1 bioB bioB ACL43850.1 ACL43850.1 bioD bioD pdhA pdhA folD folD ACL43348.1 ACL43348.1 ACL43198.1 ACL43198.1 thiL thiL bioF bioF ACL42819.1 ACL42819.1 accA accA ACL42789.1 ACL42789.1 ACL42677.1 ACL42677.1 ACL42667.1 ACL42667.1 sat sat
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa)
ACL47419.1Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
ACL47333.1TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: amr:AM1_4291 glycine oxidase ThiO. (360 aa)
ACL47331.1TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: amr:AM1_2417 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
ACL47275.1PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: tel:tll1299 dihydrolipoamide S-acetyltransferase. (432 aa)
ACL47235.1PFAM: protein of unknown function DUF540; KEGG: tel:tlr2143 unknown protein. (262 aa)
gshBKEGG: ana:all3859 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; Belongs to the prokaryotic GSH synthase family. (322 aa)
ACL47095.1TIGRFAM: serine O-acetyltransferase; KEGG: ana:alr1404 serine acetyltransferase. (213 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (306 aa)
ACL46867.1PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: tel:tll2311 cysteine synthase. (328 aa)
ACL46790.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (698 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (307 aa)
ACL46590.1KEGG: cyb:CYB_2833 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (279 aa)
ACL46575.1PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: amr:AM1_2061 homoserine dehydrogenase. (469 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (421 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa)
ACL46232.1PFAM: NAD-dependent epimerase/dehydratase; KEGG: ava:Ava_0293 UDP-sulfoquinovose synthase. (383 aa)
ACL46215.1PFAM: aminotransferase class-III; KEGG: tel:tlr0408 omega-amino acid:pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (306 aa)
mtnATranslation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (350 aa)
mtnPMethylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (290 aa)
ACL45826.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1212 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (203 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (458 aa)
ACL45203.1KEGG: ava:Ava_4077 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase. (433 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (364 aa)
ACL45196.1TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cyt:cce_1473 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
ACL44905.1PFAM: glutamine amidotransferase class-II; KEGG: ava:Ava_4279 hypothetical protein. (271 aa)
ACL44879.1TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: ava:Ava_5046 hypothetical protein. (77 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (346 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa)
ACL44521.1PFAM: LmbE family protein; KEGG: sme:SM_b21057 hypothetical protein. (292 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (277 aa)
ACL43911.1TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: npu:Npun_F5408 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (330 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (388 aa)
ACL43850.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa)
ACL43348.1PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mms:mma_1841 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein. (156 aa)
ACL43198.1PFAM: protein of unknown function DUF39; KEGG: ana:all1701 hypothetical protein. (438 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (329 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (399 aa)
ACL42819.1PFAM: DRTGG domain protein; KEGG: npu:Npun_R4741 DRTGG domain-containing protein. (362 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
ACL42789.1TIGRFAM: serine O-acetyltransferase; KEGG: amr:AM1_1002 serine acetyltransferase. (242 aa)
ACL42677.1PFAM: alpha/beta hydrolase fold; KEGG: gvi:gll2500 proable homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (338 aa)
ACL42667.1PFAM: NAD-dependent epimerase/dehydratase; KEGG: ana:alr1744 sulfolipid biosynthesis protein. (383 aa)
satKEGG: tel:tll1044 sulfate adenylyltransferase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family. (397 aa)
Your Current Organism:
Cyanothece sp. PCC7425
NCBI taxonomy Id: 395961
Other names: C. sp. PCC 7425, Cyanothece sp. ATCC 29141, Cyanothece sp. PCC 7425, Synechococcus sp. PCC 7425
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