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BF93_11280 BF93_11280 thyA thyA BF93_03415 BF93_03415 BF93_03965 BF93_03965 BF93_04865 BF93_04865 BF93_05805 BF93_05805 BF93_02875 BF93_02875 BF93_02715 BF93_02715 BF93_06470 BF93_06470 BF93_11210 BF93_11210 BF93_10990 BF93_10990 BF93_10940 BF93_10940 BF93_09815 BF93_09815 BF93_09810 BF93_09810 BF93_09495 BF93_09495 gcvT gcvT tgt tgt BF93_08360 BF93_08360 purU purU BF93_07065 BF93_07065 BF93_06915 BF93_06915 BF93_01000 BF93_01000 glyA glyA folD folD BF93_01560 BF93_01560 BF93_01930 BF93_01930 BF93_01935 BF93_01935 purN purN purH purH BF93_15395 BF93_15395 BF93_15625 BF93_15625 BF93_15810 BF93_15810 BF93_16185 BF93_16185 BF93_17090 BF93_17090 fhs fhs BF93_14190 BF93_14190 BF93_13330 BF93_13330 fmt fmt BF93_12555 BF93_12555 BF93_06850 BF93_06850 BF93_11605 BF93_11605 BF93_11490 BF93_11490 BF93_11305 BF93_11305
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BF93_11280Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (265 aa)
BF93_03415Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (610 aa)
BF93_03965Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (155 aa)
BF93_04865Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
BF93_05805Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1193 aa)
BF93_028755,10-methenyltetrahydrofolate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (227 aa)
BF93_02715Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
BF93_06470Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
BF93_11210Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
BF93_10990Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
BF93_10940Riboflavin biosynthesis protein RibD domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
BF93_09815Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (398 aa)
BF93_09810Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (279 aa)
BF93_09495Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (469 aa)
BF93_08360Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (628 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
BF93_070655-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
BF93_06915Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa)
BF93_01000Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa)
BF93_01560Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
BF93_01930Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (213 aa)
BF93_01935Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (665 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (190 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
BF93_153955,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (325 aa)
BF93_15625Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
BF93_15810Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
BF93_16185RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
BF93_17090HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
fhsFormate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (558 aa)
BF93_14190Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
BF93_13330Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (320 aa)
BF93_12555Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
BF93_06850HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
BF93_11605Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
BF93_11490MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
BF93_11305Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
Your Current Organism:
Brachybacterium phenoliresistens
NCBI taxonomy Id: 396014
Other names: B. phenoliresistens, BCRC 17589, Brachybacterium phenoliresistens Chou et al. 2007, Brachybacterium sp. phenol-A, JCM 15157, LMG 23707, LMG:23707, strain phenol-A
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