STRINGSTRING
Tgr7_0120 Tgr7_0120 Tgr7_0241 Tgr7_0241 Tgr7_0443 Tgr7_0443 dksA dksA Tgr7_0677 Tgr7_0677 folE2 folE2 Tgr7_0831 Tgr7_0831 Tgr7_0861 Tgr7_0861 Tgr7_0862 Tgr7_0862 Tgr7_0863 Tgr7_0863 Tgr7_0864 Tgr7_0864 Tgr7_0865 Tgr7_0865 queG queG Tgr7_1369 Tgr7_1369 Tgr7_1370 Tgr7_1370 folE folE Tgr7_1468 Tgr7_1468 queF queF secF secF secD secD tgt tgt queA queA queC queC queE queE cpoB cpoB tolB tolB Tgr7_2230 Tgr7_2230 tolR tolR tolQ tolQ Tgr7_2233 Tgr7_2233 ruvB ruvB ruvA ruvA ruvC ruvC Tgr7_2237 Tgr7_2237 Tgr7_2239 Tgr7_2239 Tgr7_2353 Tgr7_2353 Tgr7_2404 Tgr7_2404 Tgr7_2450 Tgr7_2450 Tgr7_2453 Tgr7_2453 Tgr7_2648 Tgr7_2648 Tgr7_2776 Tgr7_2776 Tgr7_2781 Tgr7_2781 Tgr7_2784 Tgr7_2784 Tgr7_2909 Tgr7_2909 Tgr7_2927 Tgr7_2927 Tgr7_3127 Tgr7_3127
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tgr7_0120PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: aeh:Mlg_0328 OmpA/MotB domain-containing protein. (218 aa)
Tgr7_0241PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: aeh:Mlg_2728 TonB-dependent receptor. (675 aa)
Tgr7_0443TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (284 aa)
dksATranscriptional regulator, TraR/DksA family; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (134 aa)
Tgr7_0677KEGG: tcx:Tcr_1564 TonB-dependent receptor. (672 aa)
folE2Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (270 aa)
Tgr7_0831KEGG: tcx:Tcr_1389 putative 6-pyruvoyl tetrahydropterin synthase. (126 aa)
Tgr7_0861TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (244 aa)
Tgr7_0862PFAM: MotA/TolQ/ExbB proton channel; KEGG: cvi:CV_0399 ExbB-like biopolymer transport. (240 aa)
Tgr7_0863PFAM: Biopolymer transport protein ExbD/TolR; KEGG: eba:ebA1842 biopolymer transport protein ExbD/TolR. (138 aa)
Tgr7_0864KEGG: kpe:KPK_2155 hypothetical protein. (63 aa)
Tgr7_0865PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: amc:MADE_02035 outer membrane iron(III) dicitrate receptor. (700 aa)
queG4Fe-4S cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (363 aa)
Tgr7_1369PFAM: MotA/TolQ/ExbB proton channel; KEGG: noc:Noc_2673 MotA/TolQ/ExbB proton channel. (206 aa)
Tgr7_1370PFAM: Biopolymer transport protein ExbD/TolR; KEGG: cja:CJA_1780 ExbD/TolR family protein. (140 aa)
folEPFAM: GTP cyclohydrolase I; KEGG: pfo:Pfl01_0891 GTP cyclohydrolase I. (200 aa)
Tgr7_1468PFAM: OmpA/MotB domain protein; KEGG: aav:Aave_3279 OmpA/MotB domain protein. (227 aa)
queF7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (129 aa)
secFPreprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (313 aa)
secDPreprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (623 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (371 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (364 aa)
queCExsB ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (229 aa)
queEPutative radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (227 aa)
cpoBConserved hypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (265 aa)
tolBConserved hypothetical protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (435 aa)
Tgr7_2230KEGG: aeh:Mlg_0243 TonB family protein. (308 aa)
tolRTolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (148 aa)
tolQTolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (228 aa)
Tgr7_2233KEGG: noc:Noc_0141 4-hydroxybenzoyl-CoA thioesterase. (149 aa)
ruvBHolliday junction DNA helicase B; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (353 aa)
ruvADNA recombination protein, RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
ruvCCrossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (179 aa)
Tgr7_2237KEGG: mca:MCA1220 hypothetical protein. (249 aa)
Tgr7_2239KEGG: tbd:Tbd_0444 dATP pyrophosphohydrolase. (148 aa)
Tgr7_2353Hypothetical protein; KEGG: NEWSINFRUG00000160756. (206 aa)
Tgr7_2404PFAM: Lytic transglycosylase catalytic; KEGG: bcl:ABC2523 lytic transglycosylase. (216 aa)
Tgr7_2450Surface lipoprotein-like protein; KEGG: pmy:Pmen_1927 VacJ family lipoprotein. (263 aa)
Tgr7_2453KEGG: psp:PSPPH_3887 sodium-type flagellar protein MotY, putative. (280 aa)
Tgr7_2648KEGG: aeh:Mlg_2815 TonB-dependent receptor. (602 aa)
Tgr7_2776KEGG: noc:Noc_0305 hypothetical protein. (69 aa)
Tgr7_2781KEGG: eba:ebA5358 outer membrane protein (porin). (355 aa)
Tgr7_2784KEGG: cja:CJA_2273 putative porin. (339 aa)
Tgr7_2909TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: xac:XAC3104 TonB protein. (292 aa)
Tgr7_2927ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (213 aa)
Tgr7_3127PFAM: porin Gram-negative type; KEGG: abo:ABO_2163 hypothetical protein. (333 aa)
Your Current Organism:
Thioalkalivibrio sulfidiphilus
NCBI taxonomy Id: 396588
Other names: T. sulfidiphilus HL-EbGr7, Thioalkalivibrio sp. HL-EbGR7, Thioalkalivibrio sulfidiphilus HL-EbGr7, Thioalkalivibrio sulfidiphilus str. HL-EbGr7, Thioalkalivibrio sulfidiphilus strain HL-EbGr7, Thioalkalivibrio sulfidophilus HL-EbGr7
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