STRINGSTRING
TK90_0021 TK90_0021 TK90_0022 TK90_0022 hemH hemH TK90_0293 TK90_0293 TK90_0295 TK90_0295 TK90_0296 TK90_0296 TK90_0297 TK90_0297 TK90_0298 TK90_0298 TK90_0299 TK90_0299 TK90_0354 TK90_0354 TK90_0414 TK90_0414 TK90_0436 TK90_0436 TK90_0437 TK90_0437 TK90_0438 TK90_0438 TK90_0439 TK90_0439 TK90_0440 TK90_0440 TK90_0441 TK90_0441 TK90_0442 TK90_0442 TK90_0443 TK90_0443 TK90_0444 TK90_0444 TK90_0445 TK90_0445 TK90_0547 TK90_0547 TK90_0557 TK90_0557 TK90_0559 TK90_0559 TK90_0560 TK90_0560 ruvB ruvB TK90_0562 TK90_0562 tolQ tolQ tolR tolR TK90_0565 TK90_0565 tolB tolB cpoB cpoB queE queE queC queC TK90_0591 TK90_0591 TK90_0592 TK90_0592 TK90_0867 TK90_0867 TK90_1290 TK90_1290 secF secF secD secD tgt tgt queA queA TK90_1371 TK90_1371 TK90_1382 TK90_1382 TK90_1383 TK90_1383 TK90_1384 TK90_1384 TK90_1386 TK90_1386 TK90_1460 TK90_1460 TK90_1461 TK90_1461 TK90_1462 TK90_1462 TK90_1463 TK90_1463 TK90_1464 TK90_1464 queF queF TK90_1610 TK90_1610 TK90_1690 TK90_1690 TK90_1691 TK90_1691 TK90_1814 TK90_1814 ruvA ruvA ruvC ruvC TK90_2018 TK90_2018 TK90_2019 TK90_2019 TK90_2020 TK90_2020 TK90_2021 TK90_2021 TK90_2022 TK90_2022 TK90_2023 TK90_2023 TK90_2024 TK90_2024 TK90_2027 TK90_2027 TK90_2282 TK90_2282 TK90_2405 TK90_2405 TK90_2422 TK90_2422 folE2 folE2 TK90_2479 TK90_2479
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TK90_0021PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: aeh:Mlg_2728 TonB-dependent receptor. (705 aa)
TK90_0022PFAM: porin Gram-negative type; KEGG: cja:CJA_2273 putative porin. (342 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (364 aa)
TK90_0293PFAM: OmpA/MotB domain protein; KEGG: har:HEAR2583 putative outer membrane protein 3a (II*;G;d). (213 aa)
TK90_0295PFAM: protein of unknown function DUF490; KEGG: abo:ABO_0741 hypothetical protein. (1382 aa)
TK90_0296PFAM: surface antigen (D15); surface antigen variable number repeat protein; KEGG: abo:ABO_0742 hypothetical protein. (596 aa)
TK90_0297PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase; KEGG: eba:ebA4892 transport system ATP-binding protein; Belongs to the ABC transporter superfamily. (371 aa)
TK90_0298PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: mmw:Mmwyl1_3753 binding-protein-dependent transport systems inner membrane component. (589 aa)
TK90_0299PFAM: extracellular solute-binding protein family 1; KEGG: ilo:IL1059 ABC-type Fe3+ transport system, periplasmic component. (345 aa)
TK90_0354PFAM: OmpA/MotB domain protein; KEGG: scl:sce5306 outer membrane protein. (315 aa)
TK90_0414PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: tcx:Tcr_1389 putative 6-pyruvoyl tetrahydropterin synthase. (127 aa)
TK90_0436PFAM: peptidylprolyl isomerase FKBP-type; KEGG: csa:Csal_1297 peptidylprolyl isomerase, FKBP-type. (160 aa)
TK90_0437PFAM: BFD domain protein [2Fe-2S]-binding domain protein; KEGG: aeh:Mlg_0429 BFD/(2Fe-2S)-binding domain-containing protein. (84 aa)
TK90_0438PFAM: MotA/TolQ/ExbB proton channel; KEGG: sbp:Sbal223_4165 MotA/TolQ/ExbB proton channel. (249 aa)
TK90_0439PFAM: Biopolymer transport protein ExbD/TolR; KEGG: hha:Hhal_0453 biopolymer transport protein ExbD/TolR. (132 aa)
TK90_0440PFAM: Biopolymer transport protein ExbD/TolR; KEGG: aeh:Mlg_1846 biopolymer transport protein ExbD/TolR. (140 aa)
TK90_0441TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (305 aa)
TK90_0442KEGG: mrd:Mrad2831_3164 hypothetical protein. (144 aa)
TK90_0443Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (158 aa)
TK90_0444PFAM: Hemin uptake protein hemP; KEGG: ade:Adeh_3132 hypothetical protein. (68 aa)
TK90_0445PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: ilo:IL2393 outer membrane receptor for Fe3+-dicitrate. (734 aa)
TK90_0547KEGG: csa:Csal_2317 hypothetical protein. (69 aa)
TK90_0557PFAM: Protein of unknown function DUF2069, membrane; KEGG: aeh:Mlg_0519 putative transmembrane protein. (120 aa)
TK90_0559TIGRFAM: arsenate reductase; PFAM: arsenate reductase and related; KEGG: ppg:PputGB1_1247 arsenate reductase. (118 aa)
TK90_0560PFAM: acylphosphatase; KEGG: aeh:Mlg_0522 acylphosphatase. (96 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
TK90_0562TIGRFAM: tol-pal system-associated acyl-CoA thioesterase; PFAM: thioesterase superfamily protein; KEGG: bxe:Bxe_A3916 4-hydroxybenzoyl-CoA thioesterase. (150 aa)
tolQProtein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (230 aa)
tolRProtein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (150 aa)
TK90_0565TIGRFAM: protein TolA; TonB family protein; PFAM: Tol-Pal system TolA; KEGG: aeh:Mlg_0243 TonB family protein. (337 aa)
tolBTol-Pal system beta propeller repeat protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (428 aa)
cpoBTol-pal system protein YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (276 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (232 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (227 aa)
TK90_0591PFAM: MotA/TolQ/ExbB proton channel; KEGG: noc:Noc_2673 MotA/TolQ/ExbB proton channel. (214 aa)
TK90_0592PFAM: Biopolymer transport protein ExbD/TolR; KEGG: hha:Hhal_1247 biopolymer transport protein ExbD/TolR. (141 aa)
TK90_0867Ferritin Dps family protein; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (141 aa)
TK90_1290Hypothetical protein; KEGG: rpe:RPE_4867 cytochrome c family protein. (202 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (315 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (622 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (371 aa)
queAS-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (355 aa)
TK90_1371PFAM: Amidase; KEGG: acr:Acry_2933 amidase; Belongs to the amidase family. (509 aa)
TK90_1382PFAM: Patatin; KEGG: hha:Hhal_1081 patatin. (330 aa)
TK90_1383PFAM: pentapeptide repeat protein; KEGG: noc:Noc_2153 pentapeptide repeat-containing protein. (327 aa)
TK90_1384Cellulase; KEGG: xfn:XfasM23_1953 cellulase. (137 aa)
TK90_1386PFAM: OmpA/MotB domain protein; KEGG: mes:Meso_1262 OmpA/MotB. (238 aa)
TK90_1460PFAM: periplasmic binding protein; KEGG: aeh:Mlg_2820 periplasmic binding protein. (300 aa)
TK90_1461PFAM: transport system permease protein; KEGG: aeh:Mlg_2821 transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (323 aa)
TK90_1462PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_2822 ABC transporter related. (284 aa)
TK90_1463KEGG: mgm:Mmc1_1408 hypothetical protein. (129 aa)
TK90_1464PFAM: Pirin domain protein; KEGG: hna:Hneap_1025 pirin domain protein; Belongs to the pirin family. (282 aa)
queF7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (140 aa)
TK90_1610PFAM: multicopper oxidase type 3; KEGG: hla:Hlac_1904 multicopper oxidase type 3. (354 aa)
TK90_1690Magnesium transporter; Acts as a magnesium transporter. (452 aa)
TK90_1691Magnesium transporter; Acts as a magnesium transporter. (452 aa)
TK90_1814Outer membrane protein (porin)-like protein; KEGG: nmu:Nmul_A2561 porin. (354 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (171 aa)
TK90_2018PFAM: protein of unknown function DUF28; KEGG: mca:MCA1220 hypothetical protein. (245 aa)
TK90_2019TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain protein; KEGG: hha:Hhal_1208 DJ-1 family protein. (184 aa)
TK90_2020KEGG: mca:MCA2533 carboxyl-terminal protease; TIGRFAM: carboxyl-terminal protease; PFAM: peptidase S41; PDZ/DHR/GLGF domain protein; SMART: peptidase S41; PDZ/DHR/GLGF domain protein; Belongs to the peptidase S41A family. (428 aa)
TK90_2021PFAM: Peptidase M23; KEGG: aeh:Mlg_2569 peptidase M23B. (379 aa)
TK90_2022Transcriptional regulator, ArsR family; PFAM: regulatory protein ArsR; SMART: regulatory protein ArsR; KEGG: tbd:Tbd_2395 ArsR family transcriptional regulator. (111 aa)
TK90_2023PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; KEGG: mca:MCA2536 rhodanese domain-containing protein. (142 aa)
TK90_2024PFAM: glutaredoxin; KEGG: psa:PST_4078 glutaredoxin. (92 aa)
TK90_2027KEGG: afr:AFE_2532 hypothetical protein. (192 aa)
TK90_2282PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: aeh:Mlg_0328 OmpA/MotB domain-containing protein. (221 aa)
TK90_2405TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: hha:Hhal_0937 TonB family protein. (310 aa)
TK90_2422Queuosine synthesis-like protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (217 aa)
folE2Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. (314 aa)
TK90_2479Protease Do; KEGG: mca:MCA2343 protease DO; TIGRFAM: protease Do; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; Belongs to the peptidase S1C family. (450 aa)
Your Current Organism:
Thioalkalivibrio sp. K90mix
NCBI taxonomy Id: 396595
Other names: T. sp. K90mix
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