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TK90_0011 TK90_0011 hemC hemC TK90_0233 TK90_0233 hemE hemE hemA hemA hemL hemL TK90_0398 TK90_0398 TK90_0488 TK90_0488 TK90_0654 TK90_0654 TK90_0655 TK90_0655 TK90_0656 TK90_0656 TK90_0657 TK90_0657 TK90_0658 TK90_0658 TK90_0659 TK90_0659 TK90_0660 TK90_0660 TK90_0661 TK90_0661 TK90_0662 TK90_0662 TK90_0663 TK90_0663 TK90_0664 TK90_0664 TK90_0665 TK90_0665 TK90_0666 TK90_0666 TK90_0667 TK90_0667 TK90_0668 TK90_0668 TK90_0669 TK90_0669 TK90_0670 TK90_0670 cysG cysG TK90_0672 TK90_0672 rlmL rlmL TK90_0689 TK90_0689 TK90_0690 TK90_0690 TK90_0790 TK90_0790 TK90_0791 TK90_0791 TK90_0792 TK90_0792 TK90_0793 TK90_0793 TK90_0794 TK90_0794 TK90_0795 TK90_0795 TK90_0796 TK90_0796 TK90_0797 TK90_0797 cbiD cbiD TK90_0799 TK90_0799 TK90_0800 TK90_0800 TK90_0801 TK90_0801 TK90_0802 TK90_0802 TK90_0803 TK90_0803 TK90_0804 TK90_0804 TK90_0805 TK90_0805 TK90_0806 TK90_0806 TK90_0807 TK90_0807 TK90_0808 TK90_0808 TK90_0962 TK90_0962 TK90_0963 TK90_0963 TK90_0964 TK90_0964 TK90_0966 TK90_0966 TK90_0967 TK90_0967 TK90_0968 TK90_0968 TK90_0969 TK90_0969 TK90_0970 TK90_0970 TK90_0971 TK90_0971 TK90_0972 TK90_0972 TK90_0973 TK90_0973 TK90_0974 TK90_0974 TK90_1078 TK90_1078 TK90_1079 TK90_1079 TK90_1352 TK90_1352 TK90_1353 TK90_1353 TK90_1354 TK90_1354 TK90_1451 TK90_1451 cobS cobS TK90_1453 TK90_1453 cobT cobT TK90_1455 TK90_1455 cobQ cobQ TK90_1457 TK90_1457 cobD cobD TK90_1459 TK90_1459 TK90_1511 TK90_1511 TK90_1586 TK90_1586 TK90_1652 TK90_1652 TK90_1763 TK90_1763 TK90_2250 TK90_2250 TK90_2251 TK90_2251 TK90_2253 TK90_2253 hemF hemF TK90_2280 TK90_2280
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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TK90_0011Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (271 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (315 aa)
TK90_0233PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: noc:Noc_0836 oxidoreductase FAD/NAD(P)-binding. (246 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (352 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (432 aa)
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: tcx:Tcr_1570 glutamate-1-semialdehyde-2,1-aminomutase. (425 aa)
TK90_0398PFAM: conserved hypothetical protein; KEGG: aeh:Mlg_0431 hypothetical protein. (172 aa)
TK90_0488PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: tbd:Tbd_2358 ferredoxin-NADP reductase. (263 aa)
TK90_0654PFAM: Polyketide cyclase/dehydrase; KEGG: hha:Hhal_0376 cyclase/dehydrase. (186 aa)
TK90_0655PFAM: major facilitator superfamily MFS_1; KEGG: bam:Bamb_0424 major facilitator transporter. (408 aa)
TK90_0656PFAM: GTP-binding protein HSR1-related; SMART: AAA ATPase; KEGG: aeh:Mlg_1599 GTP-binding protein, HSR1-related. (512 aa)
TK90_0657KEGG: aeh:Mlg_1600 hypothetical protein. (411 aa)
TK90_0658PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: aeh:Mlg_1710 recombination factor protein RarA. (454 aa)
TK90_0659PFAM: SNARE associated Golgi protein; KEGG: mgm:Mmc1_1105 rhodanese domain-containing protein. (230 aa)
TK90_0660PFAM: glycosyl transferase family 2; KEGG: tmz:Tmz1t_3554 glycosyl transferase family 2. (234 aa)
TK90_0661PFAM: Protein of unknown function DUF2064; KEGG: app:CAP2UW1_2821 hypothetical protein. (217 aa)
TK90_0662KEGG: gem:GM21_0424 hypothetical protein. (80 aa)
TK90_0663PFAM: DsrE family protein; KEGG: mca:MCA0352 hypothetical protein. (118 aa)
TK90_0664PFAM: Nitrate and nitrite sensing domain protein; ANTAR domain protein; KEGG: azo:azo0941 nitrate regulatory protein. (441 aa)
TK90_0665KEGG: cja:CJA_0529 nitrate-binding protein NrtA precursor, periplasmic. (475 aa)
TK90_0666TIGRFAM: nitrate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: psa:PST_4093 nitrate ABC transporter permease protein. (311 aa)
TK90_0667KEGG: psa:PST_4094 nitrate ABC transporter, ATP-binding protein, putative; TIGRFAM: nitrate ABC transporter, ATPase subunits C and D; PFAM: ABC transporter related; SMART: AAA ATPase. (266 aa)
TK90_0668TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: mca:MCA0592 nitrite reductase [NAD(P)H], large subunit. (826 aa)
TK90_0669TIGRFAM: nitrite reductase [NAD(P)H], small subunit; PFAM: Rieske [2Fe-2S] iron-sulphur domain; KEGG: pag:PLES_35491 assimilatory nitrite reductase small subunit. (123 aa)
TK90_0670PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; BFD domain protein [2Fe-2S]-binding domain protein; molybdopterin oxidoreductase Fe4S4 region; KEGG: hch:HCH_05823 anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (896 aa)
cysGuroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (482 aa)
TK90_0672PFAM: Uroporphyrinogen III synthase HEM4; KEGG: aeh:Mlg_1707 uroporphyrinogen III synthase HEM4. (284 aa)
rlmLPutative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (734 aa)
TK90_0689TIGRFAM: ABC-2 type transporter, NodJ family; PFAM: ABC-2 type transporter; KEGG: aeh:Mlg_1093 ABC transporter. (262 aa)
TK90_0690PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: hha:Hhal_0240 ABC transporter related. (311 aa)
TK90_0790PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: aeh:Mlg_2815 TonB-dependent receptor. (614 aa)
TK90_0791TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: hha:Hhal_1925 ATP--cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (184 aa)
TK90_0792Cobaltochelatase; PFAM: CobN/magnesium chelatase; KEGG: avn:Avin_27480 CobN/magnesium chelatase family protein. (1515 aa)
TK90_0793KEGG: avn:Avin_27470 hypothetical protein. (147 aa)
TK90_0794PFAM: Protein of unknown function DUF2149; KEGG: avn:Avin_27460 hypothetical protein. (96 aa)
TK90_0795cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (204 aa)
TK90_0796PFAM: CobB/CobQ domain protein glutamine amidotransferase; Cobyrinic acid ac-diamide synthase; KEGG: rso:RSp0615 cobyrinic acid a,c-diamide synthase. (430 aa)
TK90_0797TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: psb:Psyr_3174 uroporphyrin-III C-methyltransferase, C-terminal:siroheme synthase, N-terminal; Belongs to the precorrin methyltransferase family. (284 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (369 aa)
TK90_0799PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pag:PLES_22601 putative ATP-binding component of ABC transporter. (314 aa)
TK90_0800PFAM: ABC-2 type transporter; KEGG: vsa:VSAL_I2614 ABC transporter, integral membrane protein. (257 aa)
TK90_0801TIGRFAM: precorrin-3B synthase; PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: msl:Msil_3267 precorrin-3B synthase. (464 aa)
TK90_0802PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: sco:SCO3282 precorrin-8X methylmutase. (217 aa)
TK90_0803TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mch:Mchl_5690 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (251 aa)
TK90_0804precorrin-3B C17-methyltransferase; KEGG: pmy:Pmen_4574 precorrin-6Y C5,15-methyltransferase (decarboxylating) / precorrin-3 methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (261 aa)
TK90_0805KEGG: sma:SAV_1601 cobalt-precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK. (266 aa)
TK90_0806KEGG: met:M446_2444 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. (411 aa)
TK90_0807KEGG: mdi:METDI1514 putative cobalamin biosynthesis protein. (142 aa)
TK90_0808TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mea:Mex_1p0804 precorrin-4 C(11)-methyltransferase (precorrin-3 methylase); Belongs to the precorrin methyltransferase family. (254 aa)
TK90_0962KEGG: aeh:Mlg_2587 nitrate ABC transporter, ATPase subunits C and D; TIGRFAM: nitrate ABC transporter, ATPase subunits C and D; PFAM: ABC transporter related; SMART: AAA ATPase. (304 aa)
TK90_0963TIGRFAM: nitrate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: cja:CJA_0010 possible nitrate transport system permease protein. (281 aa)
TK90_0964KEGG: aeh:Mlg_2589 putative nitrate transporter component. (486 aa)
TK90_0966PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: tcx:Tcr_0034 binding-protein dependent transport system inner membrane protein. (279 aa)
TK90_0967KEGG: rpb:RPB_0308 twin-arginine translocation pathway signal. (427 aa)
TK90_0968PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: tcx:Tcr_0032 ABC transporter related. (276 aa)
TK90_0969PFAM: OsmC family protein; KEGG: hna:Hneap_2212 OsmC family protein. (182 aa)
TK90_0970KEGG: hna:Hneap_2211 acyl-CoA dehydrogenase domain protein. (379 aa)
TK90_0971PFAM: protein of unknown function DUF302; KEGG: tvo:TVN0121 hypothetical protein. (126 aa)
TK90_0972PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rubredoxin-type Fe(Cys)4 protein; KEGG: aeh:Mlg_0757 rubredoxin-type Fe(Cys)4 protein; Belongs to the FAD-dependent oxidoreductase family. (476 aa)
TK90_0973KEGG: fal:FRAAL1965 hypothetical protein. (208 aa)
TK90_0974KEGG: noc:Noc_0351 hypothetical protein. (104 aa)
TK90_1078PFAM: ABC-2 type transporter; KEGG: ppr:PBPRA3177 putative permease. (260 aa)
TK90_1079PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: hha:Hhal_1778 ABC transporter related. (325 aa)
TK90_1352PFAM: ABC-2 type transporter; KEGG: aeh:Mlg_2716 ABC-2 type transporter. (254 aa)
TK90_1353KEGG: aeh:Mlg_2715 daunorubicin resistance ABC transporter ATPase subunit; TIGRFAM: daunorubicin resistance ABC transporter ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase. (320 aa)
TK90_1354PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: mno:Mnod_2992 YbaK/prolyl-tRNA synthetase associated region. (156 aa)
TK90_1451KEGG: aeh:Mlg_1146 hypothetical protein. (209 aa)
cobSCobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (256 aa)
TK90_1453PFAM: Phosphoglycerate mutase; KEGG: ppg:PputGB1_1279 alpha-ribazole phosphatase. (190 aa)
cobTNicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (353 aa)
TK90_1455Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (495 aa)
TK90_1457TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: tbd:Tbd_2715 threonine-phosphate decarboxylase. (341 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (300 aa)
TK90_1459TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: pmy:Pmen_1752 cob(II)yrinic acid a,c-diamide reductase. (240 aa)
TK90_1511KEGG: aeh:Mlg_1372 oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (462 aa)
TK90_1586PFAM: Rieske [2Fe-2S] iron-sulphur domain; KEGG: pol:Bpro_4275 Rieske (2Fe-2S) region. (107 aa)
TK90_1652PFAM: blue (type 1) copper domain protein; multicopper oxidase type 3; KEGG: bpd:BURPS668_A2061 multicopper oxidase domain-containing protein. (486 aa)
TK90_1763PFAM: Radical SAM domain protein; KEGG: eba:ebA4360 hypothetical protein. (319 aa)
TK90_2250PFAM: Phosphoglycerate mutase; SMART: Phosphoglycerate mutase; KEGG: tbd:Tbd_1121 alpha-ribazole-5`-phosphate phosphatase CobC, putative. (195 aa)
TK90_2251N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD; PFAM: N-acetylmuramoyl-L-alanine amidase family 2; SMART: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: aha:AHA_3865 N-acetyl-anhydromuranmyl-L-alanine amidase. (188 aa)
TK90_2253PFAM: Entericidin EcnAB; KEGG: amc:MADE_01751 hypothetical protein. (52 aa)
hemFCoproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (309 aa)
TK90_2280Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mca:MCA2793 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (338 aa)
Your Current Organism:
Thioalkalivibrio sp. K90mix
NCBI taxonomy Id: 396595
Other names: T. sp. K90mix
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