(21 nodes) DNA replication initiation, and Origin recognition complex network (Manihot esculenta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

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Your Input:
	MANES_S101400	DNA helicase; Belongs to the MCM family. (833 aa)
	A0A251KSS4	AAA_16 domain-containing protein. (537 aa)
	A0A2C9U6P1	DNA helicase; Belongs to the MCM family. (768 aa)
	A0A2C9U983	DNA helicase; Belongs to the MCM family. (840 aa)
	A0A2C9UG82	DNA helicase; Belongs to the MCM family. (763 aa)
	A0A2C9UHQ4	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (854 aa)
	A0A2C9UP61	Uncharacterized protein. (595 aa)
	A0A2C9UU91	CDT1 domain-containing protein. (617 aa)
	A0A2C9V445	Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (417 aa)
	A0A2C9V511	MCM domain-containing protein; Belongs to the MCM family. (664 aa)
	A0A2C9VC38	MCM domain-containing protein; Belongs to the MCM family. (797 aa)
	A0A2C9VEZ5	DNA helicase; Belongs to the MCM family. (942 aa)
	A0A2C9VGP0	Uncharacterized protein. (363 aa)
	A0A2C9VGU7	ORC_WH_C domain-containing protein. (742 aa)
	A0A2C9VMV9	DNA helicase; Belongs to the MCM family. (726 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
	A0A2C9W1U1	Zf-primase domain-containing protein. (478 aa)
	A0A2C9W2R4	CDT1 domain-containing protein. (611 aa)
	A0A2C9WL64	Cell division control protein; Belongs to the CDC6/cdc18 family. (527 aa)
	A0A2C9WM46	Uncharacterized protein. (282 aa)
	MCM7-2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (564 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251KSS4	A0A2C9U6P1	A0A251KSS4	A0A2C9U6P1	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A251KSS4	A0A2C9U983	A0A251KSS4	A0A2C9U983	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A251KSS4	A0A2C9UG82	A0A251KSS4	A0A2C9UG82	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A251KSS4	A0A2C9UHQ4	A0A251KSS4	A0A2C9UHQ4	AAA_16 domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.998
A0A251KSS4	A0A2C9UP61	A0A251KSS4	A0A2C9UP61	AAA_16 domain-containing protein.	Uncharacterized protein.	0.981
A0A251KSS4	A0A2C9UU91	A0A251KSS4	A0A2C9UU91	AAA_16 domain-containing protein.	CDT1 domain-containing protein.	0.981
A0A251KSS4	A0A2C9V445	A0A251KSS4	A0A2C9V445	AAA_16 domain-containing protein.	Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.997
A0A251KSS4	A0A2C9V511	A0A251KSS4	A0A2C9V511	AAA_16 domain-containing protein.	MCM domain-containing protein; Belongs to the MCM family.	0.978
A0A251KSS4	A0A2C9VC38	A0A251KSS4	A0A2C9VC38	AAA_16 domain-containing protein.	MCM domain-containing protein; Belongs to the MCM family.	0.992
A0A251KSS4	A0A2C9VEZ5	A0A251KSS4	A0A2C9VEZ5	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.978
A0A251KSS4	A0A2C9VGP0	A0A251KSS4	A0A2C9VGP0	AAA_16 domain-containing protein.	Uncharacterized protein.	0.999
A0A251KSS4	A0A2C9VGU7	A0A251KSS4	A0A2C9VGU7	AAA_16 domain-containing protein.	ORC_WH_C domain-containing protein.	0.998
A0A251KSS4	A0A2C9VMV9	A0A251KSS4	A0A2C9VMV9	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A251KSS4	A0A2C9W1U1	A0A251KSS4	A0A2C9W1U1	AAA_16 domain-containing protein.	Zf-primase domain-containing protein.	0.945
A0A251KSS4	A0A2C9W2R4	A0A251KSS4	A0A2C9W2R4	AAA_16 domain-containing protein.	CDT1 domain-containing protein.	0.981
A0A251KSS4	A0A2C9WL64	A0A251KSS4	A0A2C9WL64	AAA_16 domain-containing protein.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.996
A0A251KSS4	A0A2C9WM46	A0A251KSS4	A0A2C9WM46	AAA_16 domain-containing protein.	Uncharacterized protein.	0.998
A0A251KSS4	MANES_S101400	A0A251KSS4	A0A199U9G0	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.996
A0A251KSS4	MCM7	A0A251KSS4	A0A2C9VS28	AAA_16 domain-containing protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.985
A0A251KSS4	MCM7-2	A0A251KSS4	A0A2C9WPS2	AAA_16 domain-containing protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.985