(30 nodes) Mixed, incl. HDR through Single Strand Annealing (SSA), and Sensing of DNA Double Strand Breaks network (Manihot esculenta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A251JF57	Uncharacterized protein. (1170 aa)
	A0A251JQ79	Uncharacterized protein. (191 aa)
	A0A251K0S2	Uncharacterized protein. (1230 aa)
	A0A251KP80	PWWP domain-containing protein. (1099 aa)
	A0A2C9TZF7	Helicase ATP-binding domain-containing protein. (660 aa)
	A0A2C9U2A6	Uncharacterized protein. (1406 aa)
	A0A2C9U2V9	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (888 aa)
	A0A2C9U6C5	Uncharacterized protein. (758 aa)
	A0A2C9UEA6	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (731 aa)
	A0A2C9VBE4	Uncharacterized protein. (389 aa)
	A0A2C9VFJ8	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (879 aa)
	A0A2C9VPA1	RPA_C domain-containing protein. (136 aa)
	A0A2C9VPP1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2526 aa)
	A0A2C9VTN6	Uncharacterized protein. (1269 aa)
	A0A2C9W0D7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2430 aa)
	A0A2C9W354	ERCC4 domain-containing protein. (657 aa)
	A0A2C9W4K9	Toprim domain-containing protein. (689 aa)
	A0A2C9W4N1	zf-C4_Topoisom domain-containing protein. (259 aa)
	A0A2C9W697	Ku_C domain-containing protein. (97 aa)
	A0A2C9W7P5	DUF1767 domain-containing protein. (708 aa)
	A0A2C9W8C7	Uncharacterized protein; Belongs to the RecA family. (367 aa)
	A0A2C9W8Z1	Zinc-hook domain-containing protein. (1316 aa)
	A0A2C9WDU3	DDT domain-containing protein. (714 aa)
	A0A2C9WEQ0	Uncharacterized protein. (947 aa)
	A0A2C9WGV1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (384 aa)
	A0A2C9WJ14	PPIase cyclophilin-type domain-containing protein. (342 aa)
	A0A2C9WKB7	Uncharacterized protein. (538 aa)
	A0A2C9WLF6	ERCC4 domain-containing protein. (975 aa)
	A0A2C9WM87	Uncharacterized protein. (534 aa)
	A0A2C9WQV8	Uncharacterized protein. (1224 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A251JF57	A0A251JQ79	Uncharacterized protein.	Uncharacterized protein.	0.581
A0A251JF57	A0A251KP80	Uncharacterized protein.	PWWP domain-containing protein.	0.760
A0A251JF57	A0A2C9TZF7	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.604
A0A251JF57	A0A2C9U2A6	Uncharacterized protein.	Uncharacterized protein.	0.869
A0A251JF57	A0A2C9U6C5	Uncharacterized protein.	Uncharacterized protein.	0.904
A0A251JF57	A0A2C9UEA6	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.849
A0A251JF57	A0A2C9VBE4	Uncharacterized protein.	Uncharacterized protein.	0.435
A0A251JF57	A0A2C9VPA1	Uncharacterized protein.	RPA_C domain-containing protein.	0.713
A0A251JF57	A0A2C9VPP1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.706
A0A251JF57	A0A2C9VTN6	Uncharacterized protein.	Uncharacterized protein.	0.916
A0A251JF57	A0A2C9W0D7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.849
A0A251JF57	A0A2C9W354	Uncharacterized protein.	ERCC4 domain-containing protein.	0.908
A0A251JF57	A0A2C9W4K9	Uncharacterized protein.	Toprim domain-containing protein.	0.879
A0A251JF57	A0A2C9W4N1	Uncharacterized protein.	zf-C4_Topoisom domain-containing protein.	0.879
A0A251JF57	A0A2C9W697	Uncharacterized protein.	Ku_C domain-containing protein.	0.742
A0A251JF57	A0A2C9W7P5	Uncharacterized protein.	DUF1767 domain-containing protein.	0.939
A0A251JF57	A0A2C9W8C7	Uncharacterized protein.	Uncharacterized protein; Belongs to the RecA family.	0.753
A0A251JF57	A0A2C9W8Z1	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.873
A0A251JF57	A0A2C9WDU3	Uncharacterized protein.	DDT domain-containing protein.	0.576
A0A251JF57	A0A2C9WEQ0	Uncharacterized protein.	Uncharacterized protein.	0.623