(14 nodes) Mixed, incl. DNA topoisomerase, type IA, and Restriction endonuclease type II-like network (Manihot esculenta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A251JF57	Uncharacterized protein. (1170 aa)
	A0A251JQ79	Uncharacterized protein. (191 aa)
	A0A2C9U2A6	Uncharacterized protein. (1406 aa)
	A0A2C9U2V9	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (888 aa)
	A0A2C9VBE4	Uncharacterized protein. (389 aa)
	A0A2C9VFJ8	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (879 aa)
	A0A2C9VPA1	RPA_C domain-containing protein. (136 aa)
	A0A2C9W354	ERCC4 domain-containing protein. (657 aa)
	A0A2C9W4K9	Toprim domain-containing protein. (689 aa)
	A0A2C9W4N1	zf-C4_Topoisom domain-containing protein. (259 aa)
	A0A2C9W7P5	DUF1767 domain-containing protein. (708 aa)
	A0A2C9WGV1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (384 aa)
	A0A2C9WJ14	PPIase cyclophilin-type domain-containing protein. (342 aa)
	A0A2C9WLF6	ERCC4 domain-containing protein. (975 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A251JF57	A0A251JQ79	Uncharacterized protein.	Uncharacterized protein.	0.581
A0A251JF57	A0A2C9U2A6	Uncharacterized protein.	Uncharacterized protein.	0.869
A0A251JF57	A0A2C9VBE4	Uncharacterized protein.	Uncharacterized protein.	0.435
A0A251JF57	A0A2C9VPA1	Uncharacterized protein.	RPA_C domain-containing protein.	0.713
A0A251JF57	A0A2C9W354	Uncharacterized protein.	ERCC4 domain-containing protein.	0.908
A0A251JF57	A0A2C9W4K9	Uncharacterized protein.	Toprim domain-containing protein.	0.879
A0A251JF57	A0A2C9W4N1	Uncharacterized protein.	zf-C4_Topoisom domain-containing protein.	0.879
A0A251JF57	A0A2C9W7P5	Uncharacterized protein.	DUF1767 domain-containing protein.	0.939
A0A251JF57	A0A2C9WGV1	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.850
A0A251JF57	A0A2C9WJ14	Uncharacterized protein.	PPIase cyclophilin-type domain-containing protein.	0.794
A0A251JF57	A0A2C9WLF6	Uncharacterized protein.	ERCC4 domain-containing protein.	0.794
A0A251JQ79	A0A251JF57	Uncharacterized protein.	Uncharacterized protein.	0.581
A0A251JQ79	A0A2C9U2A6	Uncharacterized protein.	Uncharacterized protein.	0.758
A0A251JQ79	A0A2C9U2V9	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.907
A0A251JQ79	A0A2C9VBE4	Uncharacterized protein.	Uncharacterized protein.	0.977
A0A251JQ79	A0A2C9VFJ8	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.581
A0A251JQ79	A0A2C9W354	Uncharacterized protein.	ERCC4 domain-containing protein.	0.992
A0A251JQ79	A0A2C9W4K9	Uncharacterized protein.	Toprim domain-containing protein.	0.821
A0A251JQ79	A0A2C9W4N1	Uncharacterized protein.	zf-C4_Topoisom domain-containing protein.	0.821
A0A251JQ79	A0A2C9W7P5	Uncharacterized protein.	DUF1767 domain-containing protein.	0.772