(13 nodes) DNA replication checkpoint signaling network (Manihot esculenta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A251JT29	Checkpoint protein; Belongs to the HUS1 family. (320 aa)
	A0A251KDB2	Uncharacterized protein; Belongs to the rad9 family. (447 aa)
	A0A2C9UHQ4	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (854 aa)
	A0A2C9UU91	CDT1 domain-containing protein. (617 aa)
	A0A2C9V593	CCHC-type domain-containing protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (274 aa)
	A0A2C9VJF8	Uncharacterized protein. (283 aa)
	A0A2C9VR47	Uncharacterized protein. (1272 aa)
	A0A2C9VSP9	Uncharacterized protein. (1001 aa)
	A0A2C9W2R4	CDT1 domain-containing protein. (611 aa)
	A0A2C9WEG8	ATPase_AAA_core domain-containing protein. (1256 aa)
	A0A2C9WEQ0	Uncharacterized protein. (947 aa)
	A0A2C9WL64	Cell division control protein; Belongs to the CDC6/cdc18 family. (527 aa)
	A0A2C9WN82	Uncharacterized protein. (612 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A251JT29	A0A251KDB2	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein; Belongs to the rad9 family.	0.992
A0A251JT29	A0A2C9V593	Checkpoint protein; Belongs to the HUS1 family.	CCHC-type domain-containing protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.898
A0A251JT29	A0A2C9VR47	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.643
A0A251JT29	A0A2C9WEG8	Checkpoint protein; Belongs to the HUS1 family.	ATPase_AAA_core domain-containing protein.	0.754
A0A251JT29	A0A2C9WEQ0	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.883
A0A251JT29	A0A2C9WL64	Checkpoint protein; Belongs to the HUS1 family.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.426
A0A251JT29	A0A2C9WN82	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.996
A0A251KDB2	A0A251JT29	Uncharacterized protein; Belongs to the rad9 family.	Checkpoint protein; Belongs to the HUS1 family.	0.992
A0A251KDB2	A0A2C9V593	Uncharacterized protein; Belongs to the rad9 family.	CCHC-type domain-containing protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.719
A0A251KDB2	A0A2C9VR47	Uncharacterized protein; Belongs to the rad9 family.	Uncharacterized protein.	0.662
A0A251KDB2	A0A2C9WEG8	Uncharacterized protein; Belongs to the rad9 family.	ATPase_AAA_core domain-containing protein.	0.617
A0A251KDB2	A0A2C9WEQ0	Uncharacterized protein; Belongs to the rad9 family.	Uncharacterized protein.	0.937
A0A251KDB2	A0A2C9WL64	Uncharacterized protein; Belongs to the rad9 family.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.446
A0A251KDB2	A0A2C9WN82	Uncharacterized protein; Belongs to the rad9 family.	Uncharacterized protein.	0.982
A0A2C9UHQ4	A0A2C9UU91	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	CDT1 domain-containing protein.	0.996
A0A2C9UHQ4	A0A2C9V593	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	CCHC-type domain-containing protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.695
A0A2C9UHQ4	A0A2C9VR47	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Uncharacterized protein.	0.478
A0A2C9UHQ4	A0A2C9W2R4	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	CDT1 domain-containing protein.	0.996
A0A2C9UHQ4	A0A2C9WEG8	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	ATPase_AAA_core domain-containing protein.	0.653
A0A2C9UHQ4	A0A2C9WL64	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.999