(43 nodes) Telomere maintenance network (Manihot esculenta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2C9UQ53	ATP-dependent DNA helicase; Belongs to the helicase family. (355 aa)
	A0A2C9UJM1	PWWP domain-containing protein. (1102 aa)
	A0A2C9UHM1	Uncharacterized protein. (132 aa)
	A0A2C9U7G9	Uncharacterized protein. (91 aa)
	A0A2C9U592	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (849 aa)
	A0A2C9U463	Helitron_like_N domain-containing protein. (115 aa)
	A0A2C9U3P5	CCHC-type domain-containing protein. (163 aa)
	A0A2C9U3K4	ATP-dependent DNA helicase; Belongs to the helicase family. (331 aa)
	A0A251LNG7	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (171 aa)
	A0A251LFU1	Uncharacterized protein. (1396 aa)
	A0A251KP80	PWWP domain-containing protein. (1099 aa)
	A0A251JT29	Checkpoint protein; Belongs to the HUS1 family. (320 aa)
	MANES_S011500	ATP-dependent DNA helicase; Belongs to the helicase family. (166 aa)
	MANES_S029600	Uncharacterized protein. (112 aa)
	MANES_S029800	Uncharacterized protein. (99 aa)
	A0A2C9WKC8	Uncharacterized protein. (125 aa)
	A0A2C9V151	Uncharacterized protein. (1399 aa)
	A0A2C9V464	Helitron_like_N domain-containing protein. (355 aa)
	A0A2C9V4V6	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1335 aa)
	A0A2C9V5J4	ATP-dependent DNA helicase; Belongs to the helicase family. (136 aa)
	A0A2C9VEH9	Uncharacterized protein. (220 aa)
	A0A2C9VN78	Telo_bind domain-containing protein. (463 aa)
	A0A2C9VP72	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (624 aa)
	A0A2C9VZI3	Uncharacterized protein. (1253 aa)
	A0A2C9W010	HD domain-containing protein. (223 aa)
	A0A2C9W4Z9	SAM domain-containing protein. (761 aa)
	A0A2C9W626	SAP domain-containing protein. (628 aa)
	A0A2C9W697	Ku_C domain-containing protein. (97 aa)
	A0A2C9W6U2	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (668 aa)
	A0A2C9W712	ATP-dependent DNA helicase; Belongs to the helicase family. (125 aa)
	A0A2C9W8Z1	Zinc-hook domain-containing protein. (1316 aa)
	A0A2C9WC44	ATP-dependent DNA helicase; Belongs to the helicase family. (510 aa)
	A0A2C9WGE9	RECA_2 domain-containing protein. (301 aa)
	A0A2C9URH8	DRMBL domain-containing protein. (428 aa)
	A0A2C9UV41	ATP-dependent DNA helicase; Belongs to the helicase family. (269 aa)
	A0A2C9UWW1	Uncharacterized protein. (537 aa)
	A0A2C9UYK0	Helicase ATP-binding domain-containing protein. (1044 aa)
	A0A2C9UYR8	Uncharacterized protein. (95 aa)
	A0A2C9UZ76	DRMBL domain-containing protein. (480 aa)
	A0A2C9UZ96	ATP-dependent DNA helicase; Belongs to the helicase family. (211 aa)
	A0A2C9V128	RECA_2 domain-containing protein. (314 aa)
	A0A2C9WNV5	OB domain-containing protein. (171 aa)
	A0A2C9WRX9	ATP-dependent DNA helicase 2 subunit KU80; Single-stranded DNA-dependent ATP-dependent helicase. (705 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251JT29	A0A251KP80	A0A251JT29	A0A251KP80	Checkpoint protein; Belongs to the HUS1 family.	PWWP domain-containing protein.	0.790
A0A251JT29	A0A2C9U3P5	A0A251JT29	A0A2C9U3P5	Checkpoint protein; Belongs to the HUS1 family.	CCHC-type domain-containing protein.	0.731
A0A251JT29	A0A2C9U592	A0A251JT29	A0A2C9U592	Checkpoint protein; Belongs to the HUS1 family.	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.	0.731
A0A251JT29	A0A2C9UJM1	A0A251JT29	A0A2C9UJM1	Checkpoint protein; Belongs to the HUS1 family.	PWWP domain-containing protein.	0.790
A0A251JT29	A0A2C9UYK0	A0A251JT29	A0A2C9UYK0	Checkpoint protein; Belongs to the HUS1 family.	Helicase ATP-binding domain-containing protein.	0.687
A0A251JT29	A0A2C9VP72	A0A251JT29	A0A2C9VP72	Checkpoint protein; Belongs to the HUS1 family.	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.	0.644
A0A251JT29	A0A2C9W626	A0A251JT29	A0A2C9W626	Checkpoint protein; Belongs to the HUS1 family.	SAP domain-containing protein.	0.562
A0A251JT29	A0A2C9W697	A0A251JT29	A0A2C9W697	Checkpoint protein; Belongs to the HUS1 family.	Ku_C domain-containing protein.	0.562
A0A251JT29	A0A2C9W6U2	A0A251JT29	A0A2C9W6U2	Checkpoint protein; Belongs to the HUS1 family.	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.	0.731
A0A251JT29	A0A2C9W8Z1	A0A251JT29	A0A2C9W8Z1	Checkpoint protein; Belongs to the HUS1 family.	Zinc-hook domain-containing protein.	0.728
A0A251JT29	A0A2C9WGE9	A0A251JT29	A0A2C9WGE9	Checkpoint protein; Belongs to the HUS1 family.	RECA_2 domain-containing protein.	0.598
A0A251JT29	A0A2C9WRX9	A0A251JT29	A0A2C9WRX9	Checkpoint protein; Belongs to the HUS1 family.	ATP-dependent DNA helicase 2 subunit KU80; Single-stranded DNA-dependent ATP-dependent helicase.	0.631
A0A251KP80	A0A251JT29	A0A251KP80	A0A251JT29	PWWP domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.790
A0A251KP80	A0A2C9U3P5	A0A251KP80	A0A2C9U3P5	PWWP domain-containing protein.	CCHC-type domain-containing protein.	0.458
A0A251KP80	A0A2C9U592	A0A251KP80	A0A2C9U592	PWWP domain-containing protein.	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.	0.458
A0A251KP80	A0A2C9URH8	A0A251KP80	A0A2C9URH8	PWWP domain-containing protein.	DRMBL domain-containing protein.	0.438
A0A251KP80	A0A2C9UWW1	A0A251KP80	A0A2C9UWW1	PWWP domain-containing protein.	Uncharacterized protein.	0.438
A0A251KP80	A0A2C9UYK0	A0A251KP80	A0A2C9UYK0	PWWP domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.757
A0A251KP80	A0A2C9UZ76	A0A251KP80	A0A2C9UZ76	PWWP domain-containing protein.	DRMBL domain-containing protein.	0.438
A0A251KP80	A0A2C9V128	A0A251KP80	A0A2C9V128	PWWP domain-containing protein.	RECA_2 domain-containing protein.	0.514