(13 nodes) MCM complex network (Manihot esculenta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MANES_S101400	DNA helicase; Belongs to the MCM family. (833 aa)
	A0A251KSK7	Uncharacterized protein. (352 aa)
	A0A251LVV6	Uncharacterized protein. (352 aa)
	A0A2C9U6P1	DNA helicase; Belongs to the MCM family. (768 aa)
	A0A2C9U983	DNA helicase; Belongs to the MCM family. (840 aa)
	A0A2C9UG82	DNA helicase; Belongs to the MCM family. (763 aa)
	A0A2C9V511	MCM domain-containing protein; Belongs to the MCM family. (664 aa)
	A0A2C9VC38	MCM domain-containing protein; Belongs to the MCM family. (797 aa)
	A0A2C9VEZ5	DNA helicase; Belongs to the MCM family. (942 aa)
	A0A2C9VL73	Uncharacterized protein. (597 aa)
	A0A2C9VMV9	DNA helicase; Belongs to the MCM family. (726 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
	MCM7-2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (564 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251KSK7	A0A2C9U6P1	A0A251KSK7	A0A2C9U6P1	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.987
A0A251KSK7	A0A2C9U983	A0A251KSK7	A0A2C9U983	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.987
A0A251KSK7	A0A2C9UG82	A0A251KSK7	A0A2C9UG82	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.987
A0A251KSK7	A0A2C9VC38	A0A251KSK7	A0A2C9VC38	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.987
A0A251KSK7	A0A2C9VL73	A0A251KSK7	A0A2C9VL73	Uncharacterized protein.	Uncharacterized protein.	0.916
A0A251KSK7	A0A2C9VMV9	A0A251KSK7	A0A2C9VMV9	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A251KSK7	MANES_S101400	A0A251KSK7	A0A199U9G0	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A251KSK7	MCM7	A0A251KSK7	A0A2C9VS28	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.984
A0A251KSK7	MCM7-2	A0A251KSK7	A0A2C9WPS2	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.984
A0A251LVV6	A0A2C9U6P1	A0A251LVV6	A0A2C9U6P1	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.987
A0A251LVV6	A0A2C9U983	A0A251LVV6	A0A2C9U983	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.987
A0A251LVV6	A0A2C9UG82	A0A251LVV6	A0A2C9UG82	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.987
A0A251LVV6	A0A2C9VC38	A0A251LVV6	A0A2C9VC38	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.987
A0A251LVV6	A0A2C9VL73	A0A251LVV6	A0A2C9VL73	Uncharacterized protein.	Uncharacterized protein.	0.916
A0A251LVV6	A0A2C9VMV9	A0A251LVV6	A0A2C9VMV9	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A251LVV6	MANES_S101400	A0A251LVV6	A0A199U9G0	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A251LVV6	MCM7	A0A251LVV6	A0A2C9VS28	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.984
A0A251LVV6	MCM7-2	A0A251LVV6	A0A2C9WPS2	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.984
A0A2C9U6P1	A0A251KSK7	A0A2C9U6P1	A0A251KSK7	DNA helicase; Belongs to the MCM family.	Uncharacterized protein.	0.987
A0A2C9U6P1	A0A251LVV6	A0A2C9U6P1	A0A251LVV6	DNA helicase; Belongs to the MCM family.	Uncharacterized protein.	0.987