(37 nodes) TCF dependent signaling in response to WNT network (Manihot esculenta)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	MANES_S022500	Histone H2B; Belongs to the histone H2B family. (139 aa)
	A0A251IW56	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (273 aa)
	A0A251M266	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3889 aa)
	A0A2C9UCK9	Uncharacterized protein. (410 aa)
	A0A2C9UG75	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (273 aa)
	A0A2C9UHS3	B30.2/SPRY domain-containing protein. (440 aa)
	A0A2C9UK39	Uncharacterized protein. (627 aa)
	A0A2C9UND2	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9UP48	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (272 aa)
	A0A2C9USQ1	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (267 aa)
	A0A2C9UT49	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9UWZ2	Methyltransf_11 domain-containing protein. (259 aa)
	A0A2C9UZL0	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A2C9V112	Histone H2B; Belongs to the histone H2B family. (147 aa)
	A0A2C9V1K4	Histone H2B; Belongs to the histone H2B family. (145 aa)
	A0A2C9V1K5	Histone domain-containing protein; Belongs to the histone H2B family. (233 aa)
	A0A2C9V3L1	Histone H2B; Belongs to the histone H2B family. (139 aa)
	A0A2C9V3M7	Uncharacterized protein. (272 aa)
	A0A2C9V3V7	Uncharacterized protein. (290 aa)
	A0A2C9V3W3	Uncharacterized protein. (163 aa)
	A0A2C9V4V6	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1335 aa)
	A0A2C9V9E2	Uncharacterized protein. (302 aa)
	A0A2C9VDQ3	Methyltransf_11 domain-containing protein. (263 aa)
	A0A2C9VF52	Ubiquitin-like domain-containing protein. (33 aa)
	A0A2C9VH03	Uncharacterized protein. (298 aa)
	A0A2C9VJU8	Histone H2B; Belongs to the histone H2B family. (140 aa)
	A0A2C9VM95	Histone H2B; Belongs to the histone H2B family. (139 aa)
	A0A2C9VP19	Uncharacterized protein. (254 aa)
	A0A2C9VP93	Uncharacterized protein. (284 aa)
	A0A2C9VSB5	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9VY91	Uncharacterized protein. (293 aa)
	A0A2C9VZZ5	Histone H2B; Belongs to the histone H2B family. (143 aa)
	A0A2C9W0H3	Histone H2B; Belongs to the histone H2B family. (147 aa)
	A0A2C9W1T3	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A2C9W5C7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (231 aa)
	A0A2C9W7T7	Uncharacterized protein. (577 aa)
	A0A2C9WNI8	Ubiquitin-like domain-containing protein. (156 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251IW56	A0A2C9UG75	A0A251IW56	A0A2C9UG75	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.900
A0A251IW56	A0A2C9UND2	A0A251IW56	A0A2C9UND2	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9UP48	A0A251IW56	A0A2C9UP48	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.996
A0A251IW56	A0A2C9USQ1	A0A251IW56	A0A2C9USQ1	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.996
A0A251IW56	A0A2C9UT49	A0A251IW56	A0A2C9UT49	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9UZL0	A0A251IW56	A0A2C9UZL0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.995
A0A251IW56	A0A2C9V9E2	A0A251IW56	A0A2C9V9E2	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.905
A0A251IW56	A0A2C9VF52	A0A251IW56	A0A2C9VF52	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9VSB5	A0A251IW56	A0A2C9VSB5	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9W1T3	A0A251IW56	A0A2C9W1T3	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.995
A0A251IW56	A0A2C9W5C7	A0A251IW56	A0A2C9W5C7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
A0A251IW56	A0A2C9W7T7	A0A251IW56	A0A2C9W7T7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.796
A0A251IW56	A0A2C9WNI8	A0A251IW56	A0A2C9WNI8	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251M266	A0A2C9UND2	A0A251M266	A0A2C9UND2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Ubiquitin-like domain-containing protein.	0.741
A0A251M266	A0A2C9UT49	A0A251M266	A0A2C9UT49	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Ubiquitin-like domain-containing protein.	0.741
A0A251M266	A0A2C9V112	A0A251M266	A0A2C9V112	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Histone H2B; Belongs to the histone H2B family.	0.476
A0A251M266	A0A2C9V1K4	A0A251M266	A0A2C9V1K4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Histone H2B; Belongs to the histone H2B family.	0.476
A0A251M266	A0A2C9V1K5	A0A251M266	A0A2C9V1K5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Histone domain-containing protein; Belongs to the histone H2B family.	0.476
A0A251M266	A0A2C9V3L1	A0A251M266	A0A2C9V3L1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Histone H2B; Belongs to the histone H2B family.	0.476
A0A251M266	A0A2C9VF52	A0A251M266	A0A2C9VF52	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Ubiquitin-like domain-containing protein.	0.741