(58 nodes) PTEN Regulation network (Manihot esculenta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2C9VDI2	Tr-type G domain-containing protein. (678 aa)
	A0A2C9VA41	WD_REPEATS_REGION domain-containing protein. (1364 aa)
	A0A2C9V9E2	Uncharacterized protein. (302 aa)
	A0A2C9V8P4	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released. (560 aa)
	A0A2C9V7U8	Uncharacterized protein. (361 aa)
	A0A2C9UZL0	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A2C9UVJ5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	A0A2C9UVF4	Protein kinase domain-containing protein. (71 aa)
	A0A2C9UV30	RING-type domain-containing protein. (459 aa)
	A0A2C9UTX0	RING-type domain-containing protein. (254 aa)
	A0A2C9UT49	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9USW3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	A0A2C9USQ1	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (267 aa)
	A0A2C9US27	RING-type domain-containing protein. (275 aa)
	A0A2C9US01	Uncharacterized protein. (130 aa)
	A0A2C9URW4	Tr-type G domain-containing protein. (672 aa)
	A0A2C9UR21	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (425 aa)
	A0A2C9UPV3	RING-type domain-containing protein. (252 aa)
	A0A2C9WNI8	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9WIX8	VEFS-Box domain-containing protein. (435 aa)
	A0A2C9WGL5	Uncharacterized protein. (1484 aa)
	A0A2C9WD42	RING-type domain-containing protein. (243 aa)
	A0A2C9W932	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1006 aa)
	A0A2C9W7T7	Uncharacterized protein. (577 aa)
	A0A2C9W5C7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (231 aa)
	A0A2C9W1T3	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A2C9UP48	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (272 aa)
	A0A2C9W068	WD_REPEATS_REGION domain-containing protein. (316 aa)
	A0A2C9VZK9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	A0A2C9VWM1	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (273 aa)
	A0A2C9VTK6	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (286 aa)
	A0A2C9UND2	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9UMX1	RING-type domain-containing protein. (254 aa)
	A0A2C9UJS7	Uncharacterized protein. (501 aa)
	A0A2C9UII1	VEFS-Box domain-containing protein. (647 aa)
	A0A2C9UHW3	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (279 aa)
	A0A2C9UG75	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (273 aa)
	A0A2C9UDS2	WD_REPEATS_REGION domain-containing protein. (370 aa)
	A0A2C9UD06	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1006 aa)
	A0A2C9U8B7	RING-type domain-containing protein. (247 aa)
	A0A2C9U5W0	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (279 aa)
	A0A2C9U4W0	RING-type domain-containing protein. (246 aa)
	A0A2C9U0P1	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (300 aa)
	A0A2C9U0F8	Uncharacterized protein. (275 aa)
	A0A251KQ18	VEFS-Box domain-containing protein. (641 aa)
	A0A251KQ06	RING-type domain-containing protein. (253 aa)
	A0A251J9H8	RING-type domain-containing protein. (253 aa)
	A0A251IW56	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (273 aa)
	A0A251ITR2	Translation factor GUF1 homolog, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (672 aa)
	A0A2C9VSB5	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2C9VRC9	Uncharacterized protein. (422 aa)
	A0A2C9VNI5	Repressor of RNA polymerase III transcription. (224 aa)
	A0A2C9VJ08	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released. (579 aa)
	A0A2C9VIQ3	WD_REPEATS_REGION domain-containing protein. (1356 aa)
	A0A2C9UPM5	EFG_C domain-containing protein. (268 aa)
	A0A2C9VHC7	Uncharacterized protein. (331 aa)
	A0A2C9VF52	Ubiquitin-like domain-containing protein. (33 aa)
	A0A2C9VER2	RING-type domain-containing protein. (241 aa)

Your Current Organism:

Manihot esculenta

NCBI taxonomy Id: 3983
Other names: M. esculenta, Manihot esculenta Crantz, Manihot utilissima, cassava, manioc, tapioca, yuca

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A251IW56	A0A2C9U0F8	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.962
A0A251IW56	A0A2C9U0P1	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.997
A0A251IW56	A0A2C9UD06	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.962
A0A251IW56	A0A2C9UG75	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.900
A0A251IW56	A0A2C9UND2	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9UP48	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.996
A0A251IW56	A0A2C9USQ1	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.996
A0A251IW56	A0A2C9UT49	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9UZL0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.995
A0A251IW56	A0A2C9V9E2	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.905
A0A251IW56	A0A2C9VF52	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9VSB5	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251IW56	A0A2C9VWM1	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.997
A0A251IW56	A0A2C9W1T3	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.995
A0A251IW56	A0A2C9W5C7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
A0A251IW56	A0A2C9W7T7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.796
A0A251IW56	A0A2C9W932	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.962
A0A251IW56	A0A2C9WGL5	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.961
A0A251IW56	A0A2C9WNI8	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Ubiquitin-like domain-containing protein.	0.833
A0A251KQ18	A0A2C9UDS2	VEFS-Box domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.979