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| | atpB-2 | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (232 aa) |
| | atpE-2 | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpF-2 | H+-transporting two-sector ATPase, B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (249 aa) |
| | atpA-2 | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (522 aa) |
| | ACD19906.1 | PFAM: H+transporting two-sector ATPase gamma subunit; KEGG: bxe:Bxe_A1886 H+-transporting two-sector ATPase, gamma subunit. (282 aa) |
| | ACD19771.1 | PFAM: Nicotinate phosphoribosyltransferase-like; KEGG: bxe:Bxe_B1188 hypothetical protein; Belongs to the NAPRTase family. (475 aa) |
| | ACD19665.1 | TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: bxe:Bxe_B1304 oxidoreductase alpha (molybdopterin) subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (788 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (386 aa) |
| | ACD17792.1 | PFAM: CinA domain protein; KEGG: bxe:Bxe_A0554 putative competence-damaged protein, CinA-like; Belongs to the CinA family. (166 aa) |
| | ACD21447.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: bxe:Bxe_B0275 putative acid-coenzyme A ligase. (546 aa) |
| | nadX | Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (276 aa) |
| | ispH-2 | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | ACD21308.1 | Hypothetical protein. (68 aa) |
| | ACD21275.1 | PFAM: phospholipase D/Transphosphatidylase; KEGG: bxe:Bxe_B3012 hypothetical protein. (590 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (516 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (508 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (653 aa) |
| | ACD19566.1 | ATPase, FliI/YscN family; KEGG: bxe:Bxe_A3118 ATPase FliI/YscN; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (442 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (291 aa) |
| | ACD19261.1 | PFAM: phosphoribosyltransferase; KEGG: bxe:Bxe_B1773 hypothetical protein. (315 aa) |
| | ACD19183.1 | TIGRFAM: malonate decarboxylase, beta subunit; KEGG: bxe:Bxe_B1847 malonate decarboxylase subunit beta. (294 aa) |
| | ACD19169.1 | PFAM: metallophosphoesterase; KEGG: bxe:Bxe_B1855 Ser/Thr protein phosphatase. (387 aa) |
| | nadE-2 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (286 aa) |
| | ACD19086.1 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; Thioesterase; phosphopantetheine-binding; KEGG: bja:bll4282 probable acetoacetyl-CoA synthetase. (1021 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: bxe:Bxe_B0641 GTP cyclohydrolase I. (212 aa) |
| | ACD18680.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: bxe:Bxe_B0631 hypothetical protein. (132 aa) |
| | ACD18674.1 | PFAM: 2OG-Fe(II) oxygenase; KEGG: bxe:Bxe_B0625 oxidoreductase, 2OG-Fe(II) oxygenase family. (270 aa) |
| | ACD18673.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: bxe:Bxe_B0624 hypothetical protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (233 aa) |
| | ACD18510.1 | PFAM: phosphoesterase PA-phosphatase related; KEGG: bxe:Bxe_B0055 membrane-associated phospholipid phosphatase. (200 aa) |
| | ACD18460.1 | KEGG: bxe:Bxe_B0528 hypothetical protein. (280 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (283 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (89 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (179 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (464 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (141 aa) |
| | ACD18229.1 | KEGG: bxe:Bxe_A0094 putative acetyltransferase. (210 aa) |
| | ACD18161.1 | Flagellar protein export ATPase FliI; KEGG: bxe:Bxe_A0163 ATPase FliI/YscN; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (549 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (453 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (228 aa) |
| | ACD17964.1 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: bxe:Bxe_A0384 sulfur carrier protein ThiS. (65 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (271 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (367 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | ACD17831.1 | PFAM: phosphoribosyltransferase; KEGG: bxe:Bxe_A0515 hypoxanthine-guanine phosphoribosyltransferase. (183 aa) |
| | ACD17825.1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (415 aa) |
| | ACD17817.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: bxe:Bxe_A0552 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (271 aa) |
| | ACD20331.1 | TIGRFAM: phosphonopyruvate decarboxylase; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: bxe:Bxe_B2234 putative thiamine pyrophosphate enzyme. (387 aa) |
| | ACD20394.1 | PFAM: phosphoesterase PA-phosphatase related; KEGG: bmu:Bmul_3315 phosphoesterase PA-phosphatase related. (230 aa) |
| | ACD20757.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: bur:Bcep18194_C7333 AMP-dependent synthetase and ligase. (650 aa) |
| | ACD20859.1 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molydopterin dinucleotide-binding region; KEGG: bxe:Bxe_B2553 formate dehydrogenase, alpha subunit, anaerobic; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (809 aa) |
| | ACD20860.1 | PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: bxe:Bxe_B2554 formate dehydrogenase-O, major subunit. (196 aa) |
| | ACD14494.1 | PFAM: aminoglycoside phosphotransferase; KEGG: psb:Psyr_3055 aminoglycoside phosphotransferase. (316 aa) |
| | ACD14495.1 | PFAM: Choline/ethanolamine kinase; aminoglycoside phosphotransferase; KEGG: psb:Psyr_3054 choline/ethanolamine kinase:aminoglycoside phosphotransferase. (313 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (195 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (270 aa) |
| | ACD14935.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: bxe:Bxe_A4206 HAD-superfamily hydrolase, subfamily IB(PSPase-like). (227 aa) |
| | ACD14957.1 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: bxe:Bxe_A4183 putative molybdopterin biosynthesis protein. (252 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: bxe:Bxe_A4177 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (171 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (293 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (188 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (279 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (336 aa) |
| | ACD15108.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: bxe:Bxe_A4015 putative acyltransferase. (252 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (300 aa) |
| | ACD15166.1 | KEGG: bxe:Bxe_A3957 putative deoxynucleoside kinase. (226 aa) |
| | ACD15169.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: bxe:Bxe_A3954 HAD-superfamily subfamily IB hydrolase, hypothetical 2. (228 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: bxe:Bxe_A3936 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (355 aa) |
| | ACD15286.1 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: bxe:Bxe_A3814 putative hydroxymethylpyrimidine kinase. (286 aa) |
| | ACD15289.1 | PFAM: protein of unknown function DUF179; KEGG: bxe:Bxe_A3811 hypothetical protein; Belongs to the UPF0301 (AlgH) family. (192 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: bxe:Bxe_A3808 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (341 aa) |
| | ACD15294.1 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: bxe:Bxe_A3807 dihydroorotase. (425 aa) |
| | ACD15295.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: bxe:Bxe_A3806 putative 1-acyl-sn-glycerol-3-phosphate acyltransferase. (281 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (189 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (566 aa) |
| | ACD15642.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3-methyltransferase; KEGG: bxe:Bxe_A3319 hypothetical protein. (137 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (404 aa) |
| | ACD15688.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3-methyltransferase; KEGG: bxe:Bxe_A3277 putative glyxalase protein. (155 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (254 aa) |
| | purD | KEGG: bxe:Bxe_A3260 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (432 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa) |
| | ACD15736.1 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (212 aa) |
| | ACD15738.1 | PFAM: metallophosphoesterase; KEGG: bxe:Bxe_A3236 putative metallo-phosphoesterase. (313 aa) |
| | psd | Phosphatidylserine decarboxylase related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (212 aa) |
| | ACD15747.1 | TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: bxe:Bxe_A3227 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (288 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | nbaC | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (174 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (409 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (312 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (353 aa) |
| | ACD16159.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mms:mma_1555 hypothetical protein. (122 aa) |
| | ACD16205.1 | PFAM: polysaccharide deacetylase; KEGG: bxe:Bxe_A2390 putative polysaccharide deacetylase. (297 aa) |
| | ACD16208.1 | PFAM: glycosyl transferase family 2; KEGG: bxe:Bxe_A2387 putative polymixin resistance glycosyltransferase. (350 aa) |
| | ACD16210.1 | KEGG: bxe:Bxe_A2385 putative small multidrug resistance transmembrane protein, DMT superfamily. (123 aa) |
| | ACD16211.1 | PFAM: glycosyl transferase family 39; KEGG: bxe:Bxe_A2384 putative transmembrane protein. (585 aa) |
| | ACD16216.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (429 aa) |
| | ACD16217.1 | TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein; KEGG: bxe:Bxe_A2378 molybdopterin converting factor, subunit 1. (85 aa) |
| | ACD16218.1 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: bxe:Bxe_A2377 putative molybdopterin synthase large subunit, MoaE. (158 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (238 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1361 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (206 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (527 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (389 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (370 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (401 aa) |
| | ACD16846.1 | PFAM: phosphatidate cytidylyltransferase; KEGG: bxe:Bxe_A1687 putative phosphatidate cytidylyltransferase; Belongs to the CDS family. (273 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa) |
| | ACD16875.1 | KEGG: bxe:Bxe_A1658 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (268 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (265 aa) |
| | ACD16924.1 | PFAM: phosphoribosyltransferase; KEGG: bxe:Bxe_A1607 putative nucleotide phosphoribosyltransferase. (196 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (448 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (438 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (557 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | ACD17012.1 | PFAM: molybdopterin binding domain; KEGG: bxe:Bxe_A1519 hypothetical protein. (278 aa) |
| | ACD17035.1 | TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: bxe:Bxe_A1486 oxidoreductase alpha (molybdopterin) subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (771 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (643 aa) |
| | ACD17095.1 | TIGRFAM: benzoate-CoA ligase family; PFAM: AMP-dependent synthetase and ligase; KEGG: bxe:Bxe_A1419 benzoate-coenzyme A ligase. (530 aa) |
| | ACD17106.1 | PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: bxe:Bxe_A1411 putative thiamine-monophosphate kinase. (327 aa) |
| | ACD17121.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: bxe:Bxe_A1395 putative acetyl-CoA synthetase. (553 aa) |
| | ACD17171.1 | PFAM: metallophosphoesterase; KEGG: bxe:Bxe_A1350 calcineurin-like phosphoesterase. (268 aa) |
| | ACD17189.1 | TIGRFAM: propionate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: bxe:Bxe_A1339 acetyl-coenzyme A synthetase. (634 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: bxe:Bxe_A1257 carbamoyl phosphate synthase large subunit; Belongs to the CarB family. (1084 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: bxe:Bxe_A1256 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (384 aa) |
| | ACD17282.1 | TIGRFAM: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: bxe:Bxe_A1096 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (197 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (368 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (369 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (204 aa) |
| | ACD17319.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (457 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (398 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa) |
| | ACD17361.1 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: bxe:Bxe_A1017 molybdenum cofactor biosynthesis protein. (214 aa) |
| | cmk | KEGG: bxe:Bxe_A0981 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (228 aa) |
| | ACD17456.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: bxe:Bxe_A0927 putative acyltransferase. (264 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (226 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (319 aa) |
| | ACD17543.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (532 aa) |
| | ACD17544.1 | KEGG: bxe:Bxe_A0814 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (299 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (379 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | ACD17550.1 | TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: bxe:Bxe_A0808 bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (331 aa) |
| | ACD17553.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (404 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (338 aa) |
| | adk | Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (221 aa) |
| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (214 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa) |
| | kynU-2 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (416 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (398 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa) |
| | purC | KEGG: bxe:Bxe_A0692 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (296 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | ACD17724.1 | Transporter-associated region; PFAM: CBS domain containing protein; transporter-associated region; KEGG: bxe:Bxe_A0626 putative Mg2+ and Co2+ transporter, CorC family. (311 aa) |
| | purH | KEGG: bxe:Bxe_A0619 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (521 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (353 aa) |
| | ACD17757.1 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; KEGG: bxe:Bxe_A0593 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (462 aa) |
| | ACD17784.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: bxe:Bxe_A0562 putative glyoxalase/bleomycin resistance protein, dioxygenase superfamily. (137 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (332 aa) |
| | folE2 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. (268 aa) |
| | ACD19996.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: bxe:Bxe_B1085 AMP-binding enzyme. (563 aa) |
| | ACD20042.1 | PFAM: phospholipid/glycerol acyltransferase; KEGG: bxe:Bxe_B1022 putative acyltransferase. (236 aa) |
| | ACD20056.1 | PFAM: CDP-diacylglycerol pyrophosphatase; KEGG: bxe:Bxe_B1010 CDP-diacylglycerol diphosphatase. (262 aa) |
| | ACD20146.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: reu:Reut_A2755 glyoxalase/bleomycin resistance protein/dioxygenase. (153 aa) |
| | ACD20235.1 | KEGG: bxe:Bxe_B2108 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (430 aa) |
| | ACD20256.1 | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (354 aa) |
| | phnN | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (184 aa) |
| | ACD20325.1 | KEGG: bxe:Bxe_B2227 hypothetical protein. (195 aa) |
| | acsA-2 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa) |
| | ACD19929.1 | PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: bxe:Bxe_B0357 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (467 aa) |
| | atpD-2 | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (492 aa) |
| | atpC-2 | Alternate F1F0 ATPase, F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (152 aa) |
