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| | Daci_4761 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: aav:Aave_3737 RNA polymerase, sigma-24 subunit, ECF subfamily. (174 aa) |
| | Daci_4847 | KEGG: pna:Pnap_3738 hypothetical protein. (587 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1342 aa) |
| | Daci_4868 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: aav:Aave_3113 RNA polymerase, sigma-24 subunit, ECF subfamily. (237 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (559 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (731 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (420 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: ajs:Ajs_2390 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1052 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: aav:Aave_2610 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (388 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa) |
| | Daci_5003 | PFAM: molybdopterin binding domain; KEGG: aav:Aave_1441 molybdopterin binding domain. (272 aa) |
| | Daci_5008 | PFAM: phosphoribosyltransferase; KEGG: aav:Aave_1435 phosphoribosyltransferase. (174 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (458 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (677 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (808 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | Daci_5104 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (410 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (351 aa) |
| | Daci_5225 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (477 aa) |
| | priB | Putative primosomal replication protein; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (96 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (405 aa) |
| | Daci_5267 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma factor RpoE; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: aav:Aave_1189 RNA polymerase, sigma-24 subunit, ECF subfamily. (223 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (437 aa) |
| | Daci_5290 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: pna:Pnap_1084 RNA polymerase, sigma-24 subunit, ECF subfamily. (194 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (947 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa) |
| | Daci_5383 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: aav:Aave_3449 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (349 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (298 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (214 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa) |
| | pncB-2 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (399 aa) |
| | nadE-2 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (566 aa) |
| | Daci_5738 | PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: smd:Smed_2364 putative adenylate/guanylate cyclase. (553 aa) |
| | Daci_5890 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psb:Psyr_2580 sigma-70 region 2; Belongs to the sigma-70 factor family. ECF subfamily. (159 aa) |
| | Daci_5893 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: azo:azo2373 putative sigma-70 factor, ECF subfamily. (171 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (476 aa) |
| | Daci_6001 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: ajs:Ajs_3915 DNA polymerase III, delta subunit. (350 aa) |
| | Daci_6012 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: bte:BTH_I0997 RNA polymerase sigma-70 factor, ECF family. (313 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa) |
| | Daci_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | Daci_0057 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: ajs:Ajs_0037 RNA polymerase, sigma-24 subunit, ECF subfamily. (196 aa) |
| | Daci_0076 | TIGRFAM: benzoate-CoA ligase family; PFAM: AMP-dependent synthetase and ligase; KEGG: reh:H16_B1918 benzoate-coenzyme A ligase. (518 aa) |
| | Daci_0087 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: vei:Veis_3179 acetoacetyl-CoA synthase. (704 aa) |
| | Daci_0097 | KEGG: ajs:Ajs_4160 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (211 aa) |
| | Daci_0160 | PFAM: RNA-directed DNA polymerase (Reverse transcriptase); KEGG: hch:HCH_03958 retron-type reverse transcriptase. (658 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (231 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (287 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (179 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (517 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (194 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1370 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1409 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (390 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (762 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (237 aa) |
| | Daci_0641 | KEGG: aav:Aave_4392 flagellar protein export ATPase FliI; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (480 aa) |
| | Daci_0674 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (538 aa) |
| | Daci_0708 | PFAM: CinA domain protein; KEGG: ajs:Ajs_0354 CinA domain protein; Belongs to the CinA family. (163 aa) |
| | apaG | PFAM: ApaG domain protein; KEGG: aav:Aave_0437 ApaG domain protein. (156 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (410 aa) |
| | Daci_0755 | PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: pla:Plav_3451 phosphate butyryltransferase. (492 aa) |
| | Daci_0781 | KEGG: rha:RHA1_ro03885 hypothetical protein. (213 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: ajs:Ajs_4058 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (275 aa) |
| | Daci_0852 | KEGG: aav:Aave_4669 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | Daci_0910 | PFAM: fumarate lyase; KEGG: pol:Bpro_1855 3-carboxy-cis,cis-muconate cycloisomerase. (458 aa) |
| | nadX | Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (267 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (387 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purC | KEGG: ajs:Ajs_3928 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (307 aa) |
| | queA | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (388 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (307 aa) |
| | Daci_1169 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: xcb:XC_0556 RNA polymerase sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (498 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (252 aa) |
| | Daci_1271 | PFAM: CBS domain containing protein; transporter-associated region; KEGG: pol:Bpro_4209 CBS domain. (307 aa) |
| | Daci_1276 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (300 aa) |
| | Daci_1278 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (284 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa) |
| | Daci_1418 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (189 aa) |
| | Daci_1450 | TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: FecR protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: pen:PSEEN1038 FecR-like transmembrane sensor. (440 aa) |
| | Daci_1495 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | Daci_1500 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (363 aa) |
| | Daci_1501 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (973 aa) |
| | Daci_1541 | KEGG: bbr:BB4286 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (293 aa) |
| | purH | KEGG: aav:Aave_0896 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (532 aa) |
| | Daci_1578 | PFAM: protein of unknown function DUF179; KEGG: ajs:Ajs_3573 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (199 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: ajs:Ajs_3570 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | Daci_1582 | PFAM: amidohydrolase; KEGG: ajs:Ajs_3569 amidohydrolase. (431 aa) |
| | Daci_1624 | PFAM: Primase 2; KEGG: bpl:BURPS1106A_0113 hypothetical protein. (309 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (314 aa) |
| | Daci_1761 | TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: mpt:Mpe_A1385 acetyl-coenzyme A synthetase. (660 aa) |
| | Daci_1766 | TIGRFAM: malonate decarboxylase, beta subunit; KEGG: mpt:Mpe_A2893 beta subunit of malonate decarboxylase. (305 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (171 aa) |
| | Daci_1836 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: aav:Aave_3845 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (121 aa) |
| | queE | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (212 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (438 aa) |
| | Daci_1933 | KEGG: bbr:BB3510 phage-related hypothetical protein. (323 aa) |
| | Daci_1991 | PFAM: phosphate acetyl/butaryl transferase; KEGG: acr:Acry_3031 phosphate butyryltransferase. (324 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (220 aa) |
| | Daci_2144 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (349 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (201 aa) |
| | Daci_2149 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (499 aa) |
| | Daci_2150 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (377 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (434 aa) |
| | purM | KEGG: ajs:Ajs_2994 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (350 aa) |
| | Daci_2249 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: vei:Veis_4543 carbon-monoxide dehydrogenase (acceptor). (796 aa) |
| | Daci_2270 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: pna:Pnap_2133 acetoacetyl-CoA synthase. (654 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (212 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | Daci_2540 | KEGG: dar:Daro_1107 hypothetical protein. (593 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (222 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (666 aa) |
| | Daci_2842 | KEGG: tcx:Tcr_1006 hypothetical protein. (96 aa) |
| | Daci_2951 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: rso:RS00872 probable extracytoplasmic function sigma factor transcription regulator protein; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (495 aa) |
| | Daci_3002 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: ajs:Ajs_2554 RNA polymerase, sigma-24 subunit, ECF subfamily. (191 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (540 aa) |
| | Daci_3044 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: aav:Aave_0375 ATP dependent DNA ligase. (563 aa) |
| | Daci_3171 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: bam:Bamb_3853 aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding. (973 aa) |
| | Daci_3220 | PFAM: DnaB domain protein helicase domain protein; KEGG: ajs:Ajs_3212 replicative DNA helicase. (456 aa) |
| | Daci_3225 | Hypothetical protein. (101 aa) |
| | Daci_3268 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mms:mma_3497 RNA polymerase sigma-70 factor, ECF subfamily. (163 aa) |
| | Daci_3271 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: mms:mma_3485 RNA polymerase sigma-70 factor, ECF subfamily. (168 aa) |
| | Daci_3274 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: psb:Psyr_1040 RNA polymerase sigma factor, ECF subfamily. (167 aa) |
| | Daci_3299 | PFAM: BolA family protein; KEGG: ajs:Ajs_1674 BolA family protein; Belongs to the BolA/IbaG family. (93 aa) |
| | Daci_3385 | PFAM: GCN5-related N-acetyltransferase; thioesterase superfamily protein; KEGG: ajs:Ajs_1714 thioesterase superfamily protein. (287 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (228 aa) |
| | Daci_3389 | KEGG: aav:Aave_3411 DNA-directed DNA polymerase. (349 aa) |
| | Daci_3399 | Hypothetical protein; KEGG: csa:Csal_0002 DNA polymerase III, beta subunit. (174 aa) |
| | Daci_3411 | SMART: DNA-directed DNA polymerase; KEGG: xfa:XF0683 phage-related DNA polymerase. (704 aa) |
| | Daci_3426 | TIGRFAM: phage/plasmid primase, P4 family; PFAM: primase P4; Primase 2; KEGG: bcl:ABC1368 hypothetical protein. (857 aa) |
| | Daci_3470 | PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); KEGG: ajs:Ajs_0352 UDP-N-acetylglucosamine 1-carboxyvinyltransferase. (465 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (484 aa) |
| | Daci_3501 | KEGG: ajs:Ajs_1830 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1194 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | purD | KEGG: ajs:Ajs_1899 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (427 aa) |
| | Daci_3540 | PFAM: DNA polymerase III chi subunit HolC; KEGG: aav:Aave_3161 DNA polymerase III chi subunit, HolC. (143 aa) |
| | Daci_3563 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: pfl:PFL_2291 RNA polymerase sigma factor FecI; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa) |
| | adk | Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (265 aa) |
| | Daci_3807 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mms:mma_1917 RNA polymerase sigma-70 factor, ECF subfamily. (192 aa) |
| | Daci_3816 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: aav:Aave_1485 aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding. (750 aa) |
| | Daci_3839 | Hypothetical protein; KEGG: aav:Aave_1466 serine/threonine protein kinase. (262 aa) |
| | Daci_3840 | KEGG: aav:Aave_1467 tetratricopeptide TPR_2 repeat protein. (164 aa) |
| | Daci_3943 | KEGG: vei:Veis_2563 hypothetical protein. (190 aa) |
| | Daci_3965 | TIGRFAM: propionate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: ajs:Ajs_2016 propionate--CoA ligase. (628 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (348 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (238 aa) |
| | Daci_4110 | PFAM: DnaB domain protein helicase domain protein; KEGG: bvi:Bcep1808_1163 DnaB domain protein helicase, C-terminal domain protein. (454 aa) |
| | Daci_4213 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: bxe:Bxe_B1629 sigma-24 (FecI); Belongs to the sigma-70 factor family. ECF subfamily. (202 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1128 aa) |
| | Daci_4339 | TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: ajs:Ajs_2523 DNA ligase (ATP). (871 aa) |
| | Daci_4348 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (520 aa) |
| | Daci_4351 | KEGG: nwi:Nwi_0342 hypothetical protein. (66 aa) |
| | Daci_4468 | PFAM: AMP-dependent synthetase and ligase; KEGG: bbr:BB4413 probable acid-coenzyme A ligase. (546 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (406 aa) |
| | Daci_4745 | KEGG: bmn:BMA10247_0877 hypothetical protein. (284 aa) |
| | Daci_4750 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: pen:PSEEN4328 RNA polymerase sigma-70 factor, ECF subfamily. (199 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa) |
