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aroE aroE Spea_0226 Spea_0226 argC argC argB argB Spea_0229 Spea_0229 argG argG argH argH aroK aroK aroB aroB Spea_0327 Spea_0327 Spea_0344 Spea_0344 Spea_0345 Spea_0345 Spea_0346 Spea_0346 ilvE ilvE ilvD ilvD ilvA ilvA lysA lysA dapF dapF Spea_0527 Spea_0527 aroQ aroQ Spea_0561 Spea_0561 Spea_0631 Spea_0631 Spea_0735 Spea_0735 argR argR Spea_0941 Spea_0941 Spea_1012 Spea_1012 Spea_1013 Spea_1013 Spea_1054 Spea_1054 Spea_1059 Spea_1059 Spea_1066 Spea_1066 thrB thrB Spea_1068 Spea_1068 glsA glsA Spea_1541 Spea_1541 trpA trpA trpB trpB trpC trpC trpD trpD Spea_1589 Spea_1589 Spea_1590 Spea_1590 asd asd Spea_1794 Spea_1794 Spea_1809 Spea_1809 Spea_1810 Spea_1810 Spea_1910 Spea_1910 Spea_1911 Spea_1911 Spea_1942 Spea_1942 dapA dapA Spea_2037 Spea_2037 serC serC Spea_2070 Spea_2070 aroA aroA Spea_2252 Spea_2252 Spea_2254 Spea_2254 Spea_2435 Spea_2435 hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI Spea_2543 Spea_2543 Spea_2583 Spea_2583 aroC aroC Spea_2635 Spea_2635 Spea_2715 Spea_2715 Spea_2863 Spea_2863 dapD dapD Spea_2953 Spea_2953 dapB dapB Spea_3227 Spea_3227 Spea_3228 Spea_3228 argD argD Spea_3519 Spea_3519 Spea_3654 Spea_3654 Spea_3791 Spea_3791 leuD leuD leuC leuC leuB leuB leuA leuA argA argA Spea_3916 Spea_3916 menF menF ubiC ubiC
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aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa)
Spea_0226TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: slo:Shew_0201 acetylornithine deacetylase (ArgE). (383 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (329 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (267 aa)
Spea_0229Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (301 aa)
argGPFAM: argininosuccinate synthase; KEGG: slo:Shew_0205 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: slo:Shew_0206 argininosuccinate lyase. (456 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa)
Spea_0327KEGG: slo:Shew_0278 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (363 aa)
Spea_0344Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa)
Spea_0345TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: slo:Shew_0289 acetolactate synthase, large subunit, biosynthetic type. (569 aa)
Spea_0346KEGG: shw:Sputw3181_3753 amino acid-binding ACT domain protein. (88 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
ilvDKEGG: spc:Sputcn32_3612 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (615 aa)
ilvAThreonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (516 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
Spea_0527Glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: aha:AHA_1626 NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
Spea_0561KEGG: slo:Shew_0521 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (797 aa)
Spea_0631PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: slo:Shew_3196 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (409 aa)
Spea_0735KEGG: slo:Shew_0779 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (456 aa)
argRArginine repressor, ArgR; Regulates arginine biosynthesis genes. (156 aa)
Spea_0941TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase; KEGG: dps:DP1920 hypothetical protein. (230 aa)
Spea_1012TIGRFAM: glutamate synthase, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: spc:Sputcn32_1135 glutamate synthase, small subunit. (469 aa)
Spea_1013PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: slo:Shew_1032 glutamate synthase (ferredoxin). (1482 aa)
Spea_1054TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: slo:Shew_1068 chorismate mutase. (384 aa)
Spea_1059TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: sbm:Shew185_1264 chorismate mutase. (657 aa)
Spea_1066KEGG: slo:Shew_1079 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa)
Spea_1068KEGG: slo:Shew_1081 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (428 aa)
glsAPFAM: Glutaminase, core; KEGG: sbm:Shew185_3050 glutaminase; Belongs to the glutaminase family. (304 aa)
Spea_1541PFAM: acylphosphatase; KEGG: saz:Sama_1328 acylphosphatase. (91 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (409 aa)
trpCPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Indole-3-glycerol phosphate synthase; KEGG: slo:Shew_2254 indole-3-glycerol-phosphate synthase., phosphoribosylanthranilate isomerase; Belongs to the TrpC family. (475 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (358 aa)
Spea_1589TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: shn:Shewana3_1519 glutamine amidotransferase of anthranilate synthase. (204 aa)
Spea_1590TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: slo:Shew_2251 anthranilate synthase component I. (527 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
Spea_1794PFAM: ferredoxin-dependent glutamate synthase; KEGG: slo:Shew_1659 ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (550 aa)
Spea_1809PFAM: glycosyl transferase family 3; KEGG: sfr:Sfri_1507 glycosyl transferase, family 3. (408 aa)
Spea_1810PFAM: ANTAR domain protein; KEGG: sfr:Sfri_1508 response regulator receiver and ANTAR domain protein. (196 aa)
Spea_1910TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: sdn:Sden_2123 acetolactate synthase, small subunit. (164 aa)
Spea_1911TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: slo:Shew_1776 acetolactate synthase, large subunit, biosynthetic type. (573 aa)
Spea_1942PFAM: NAD-glutamate dehydrogenase; KEGG: slo:Shew_1809 NAD-glutamate dehydrogenase. (1614 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
Spea_2037TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: shw:Sputw3181_2219 para-aminobenzoate synthase, subunit I. (490 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa)
Spea_2070Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: slo:Shew_1951 aspartate transaminase. (397 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa)
Spea_2252PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sfr:Sfri_2144 NADH:flavin oxidoreductase/NADH oxidase. (671 aa)
Spea_2254TIGRFAM: L-asparaginase, type I; PFAM: Asparaginase/glutaminase; KEGG: slo:Shew_1940 L-asparaginases, type I. (338 aa)
Spea_2435Asparaginase; PFAM: peptidase T2 asparaginase 2; KEGG: slo:Shew_2171 peptidase T2, asparaginase 2. (361 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (299 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sfr:Sfri_1718 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa)
hisBKEGG: slo:Shew_2200 histidinol-phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; In the N-terminal section; belongs to the histidinol- phosphatase family. (364 aa)
hisHImidazoleglycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (247 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sfr:Sfri_1715 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisIPFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: sfr:Sfri_1713 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (212 aa)
Spea_2543PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: slo:Shew_1555 Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (343 aa)
Spea_2583TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: slo:Shew_1509 asparagine synthase (glutamine-hydrolyzing). (554 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa)
Spea_2635PFAM: aminotransferase class I and II; KEGG: vpa:VP0019 valine-pyruvate aminotransferase. (416 aa)
Spea_2715PFAM: Pyridoxal-dependent decarboxylase; KEGG: slo:Shew_2535 pyridoxal-dependent decarboxylase. (548 aa)
Spea_2863PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: pol:Bpro_3376 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. (314 aa)
dapDKEGG: slo:Shew_2638 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; PFAM: transferase hexapeptide repeat containing protein; Belongs to the transferase hexapeptide repeat family. (274 aa)
Spea_2953TIGRFAM: glutamate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase; KEGG: vfi:VF1064 glutamate decarboxylase; Belongs to the group II decarboxylase family. (464 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (274 aa)
Spea_3227PFAM: ferredoxin-dependent glutamate synthase; SMART: zinc finger CDGSH-type domain protein; KEGG: vpa:VPA0765 putative glutamate synthetase. (514 aa)
Spea_3228TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: sbl:Sbal_1573 HAD-superfamily hydrolase, subfamily IB (PSPase-like). (196 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: slo:Shew_0578 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
Spea_3519TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: shn:Shewana3_0606 glutamine amidotransferase of anthranilate synthase. (190 aa)
Spea_3654PFAM: aminotransferase class I and II; KEGG: pcr:Pcryo_0738 aminotransferase, class I and II. (411 aa)
Spea_3791PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: slo:Shew_3372 arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (344 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa)
argAKEGG: slo:Shew_3478 amino-acid N-acetyltransferase; TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; Belongs to the acetyltransferase family. ArgA subfamily. (440 aa)
Spea_3916TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: shm:Shewmr7_3719 glutamine synthetase, type I. (469 aa)
menFIsochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. (452 aa)
ubiCChorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (185 aa)
Your Current Organism:
Shewanella pealeana
NCBI taxonomy Id: 398579
Other names: S. pealeana ATCC 700345, Shewanella pealeana ATCC 700345, Shewanella pealeana str. ATCC 700345, Shewanella pealeana strain ATCC 700345
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