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cysQ cysQ pepA pepA Spea_0502 Spea_0502 Spea_0551 Spea_0551 Spea_0560 Spea_0560 Spea_0562 Spea_0562 gshB gshB Spea_0653 Spea_0653 cysI cysI cysH cysH cysD cysD cysN cysN Spea_0665 Spea_0665 cysC cysC Spea_0700 Spea_0700 metK metK Spea_0823 Spea_0823 pepA-2 pepA-2 mtnN mtnN gshA gshA Spea_1270 Spea_1270 cysQ-2 cysQ-2 Spea_1486 Spea_1486 Spea_1527 Spea_1527 Spea_1564 Spea_1564 Spea_1682 Spea_1682 Spea_1793 Spea_1793 Spea_1864 Spea_1864 Spea_1933 Spea_1933 Spea_1936 Spea_1936 Spea_2228 Spea_2228 Spea_2295 Spea_2295 Spea_2347 Spea_2347 Spea_2479 Spea_2479 Spea_2520 Spea_2520 Spea_2525 Spea_2525 Spea_2663 Spea_2663 Spea_2664 Spea_2664 Spea_2759 Spea_2759 Spea_2890 Spea_2890 Spea_2964 Spea_2964 Spea_3090 Spea_3090 Spea_3091 Spea_3091 luxS luxS Spea_3181 Spea_3181 metE metE Spea_3220 Spea_3220 gshB-2 gshB-2 Spea_3384 Spea_3384 Spea_3401 Spea_3401 Spea_3653 Spea_3653 Spea_3850 Spea_3850 Spea_4063 Spea_4063 Spea_4068 Spea_4068
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (269 aa)
pepALeucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (510 aa)
Spea_0502PFAM: Glutathione S-transferase domain; KEGG: ppr:PBPRB0252 putative glutathione S-transferase. (237 aa)
Spea_0551dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (307 aa)
Spea_0560KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa)
Spea_0562KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
gshBKEGG: slo:Shew_3225 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; Belongs to the prokaryotic GSH synthase family. (317 aa)
Spea_0653Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (598 aa)
cysISulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (565 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (251 aa)
cysDTIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: sbm:Shew185_0928 sulfate adenylyltransferase, small subunit. (302 aa)
cysNSulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa)
Spea_0665PFAM: Citrate transporter; TrkA-C domain protein; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: she:Shewmr4_3070 TrkA-C domain protein. (574 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (205 aa)
Spea_0700PepB aminopeptidase; PFAM: peptidase M17 leucyl aminopeptidase domain protein; KEGG: shn:Shewana3_3402 peptidase M17, leucyl aminopeptidase domain protein. (425 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
Spea_0823TIGRFAM: aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: son:SO_1059 aminopeptidase N. (889 aa)
pepA-2Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (502 aa)
mtnNAdenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
gshATIGRFAM: glutamate--cysteine ligase; KEGG: sbl:Sbal_1031 glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (522 aa)
Spea_1270KEGG: sfu:Sfum_1322 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (406 aa)
cysQ-23'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (262 aa)
Spea_1486TIGRFAM: serine O-acetyltransferase; KEGG: she:Shewmr4_1737 serine O-acetyltransferase. (273 aa)
Spea_1527PFAM: Thioredoxin domain; KEGG: slo:Shew_2231 thioredoxin domain protein. (281 aa)
Spea_1564Purine or other phosphorylase family 1; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (270 aa)
Spea_1682TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
Spea_1793PFAM: Auxin Efflux Carrier; KEGG: sfr:Sfri_2339 auxin efflux carrier. (306 aa)
Spea_1864KEGG: sbm:Shew185_2658 gamma-glutamyltransferase; TIGRFAM: gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase. (599 aa)
Spea_1933PFAM: GAF domain protein; KEGG: shw:Sputw3181_1805 putative GAF sensor protein. (152 aa)
Spea_1936TIGRFAM: aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: slo:Shew_1803 aminopeptidase N. (853 aa)
Spea_2228Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: sfr:Sfri_2024 aspartate transaminase. (397 aa)
Spea_2295PFAM: glutathione synthase; glutathione synthase ATP-binding; KEGG: shn:Shewana3_2339 glutathione synthase, ATP-binding. (527 aa)
Spea_2347PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sbm:Shew185_2117 pyridoxal-5'-phosphate-dependent protein beta subunit. (358 aa)
Spea_2479PFAM: S-adenosylmethionine decarboxylase; KEGG: saz:Sama_1962 adenosylmethionine decarboxylase. (306 aa)
Spea_2520KEGG: slo:Shew_1789 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (406 aa)
Spea_2525PFAM: Glutathione S-transferase domain; KEGG: slo:Shew_1780 glutathione S-transferase, N-terminal domain. (241 aa)
Spea_2663TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: slo:Shew_2490 anion transporter. (464 aa)
Spea_2664Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: slo:Shew_2491 methionine gamma-lyase. (393 aa)
Spea_2759PFAM: peptidase M17 leucyl aminopeptidase domain protein; KEGG: slo:Shew_1677 leucyl aminopeptidase; Belongs to the peptidase M17 family. (453 aa)
Spea_2890PFAM: flavodoxin/nitric oxide synthase; KEGG: sbm:Shew185_1438 flavodoxin/nitric oxide synthase. (154 aa)
Spea_2964PFAM: glutathione peroxidase; KEGG: sfr:Sfri_2764 glutathione peroxidase; Belongs to the glutathione peroxidase family. (160 aa)
Spea_3090PFAM: peptidase M17 leucyl aminopeptidase domain protein; KEGG: spc:Sputcn32_0955 peptidase M17, leucyl aminopeptidase domain protein; Belongs to the peptidase M17 family. (512 aa)
Spea_3091KEGG: she:Shewmr4_0948 aminoacyl-histidine dipeptidase; TIGRFAM: aminoacyl-histidine dipeptidase; PFAM: peptidase M20; peptidase dimerisation domain protein. (486 aa)
luxSQuorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (169 aa)
Spea_3181PFAM: Glutathione S-transferase domain; KEGG: slo:Shew_2968 glutathione S-transferase, N-terminal domain; Belongs to the GST superfamily. (207 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa)
Spea_3220PFAM: protein of unknown function DUF1704; KEGG: slo:Shew_2900 protein of unknown function DUF1704. (664 aa)
gshB-2Glutathione synthase; PFAM: protein of unknown function DUF201; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; KEGG: ppr:PBPRB1479 putative Glutathione synthase; Ribosomal protein S6 modification enzyme; Belongs to the prokaryotic GSH synthase family. (339 aa)
Spea_3384Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1210 aa)
Spea_3401Adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; alanine dehydrogenase/PNT domain protein; Acetohydroxy acid isomeroreductase catalytic domain protein; S-adenosyl-L-homocysteine hydrolase, NAD binding; KEGG: mja:MJ1388 S-adenosyl-L-homocysteine hydrolase. (406 aa)
Spea_3653PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ilo:IL2163 cysteine synthase. (370 aa)
Spea_3850PFAM: purine or other phosphorylase family 1; KEGG: son:SO_3705 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase, putative. (279 aa)
Spea_4063PFAM: Glutathione S-transferase domain; KEGG: son:SO_4697 glutathione S-transferase. (233 aa)
Spea_4068TIGRFAM: glutathione-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: slo:Shew_3660 glutathione-disulfide reductase. (451 aa)
Your Current Organism:
Shewanella pealeana
NCBI taxonomy Id: 398579
Other names: S. pealeana ATCC 700345, Shewanella pealeana ATCC 700345, Shewanella pealeana str. ATCC 700345, Shewanella pealeana strain ATCC 700345
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