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Spea_3855 Spea_3855 Spea_3793 Spea_3793 Spea_3774 Spea_3774 Spea_3575 Spea_3575 astD astD Spea_3490 Spea_3490 Spea_3369 Spea_3369 Spea_3227 Spea_3227 maeA maeA dapB dapB Spea_3066 Spea_3066 Spea_3014 Spea_3014 dapD dapD Spea_2858 Spea_2858 Spea_2857 Spea_2857 aroC aroC Spea_2551 Spea_2551 lpxM lpxM astE astE nadA nadA Spea_2186 Spea_2186 aroA aroA dapE dapE dapA dapA Spea_1942 Spea_1942 Spea_1921 Spea_1921 Spea_1794 Spea_1794 Spea_1618 Spea_1618 asd asd astB astB Spea_1066 Spea_1066 Spea_1059 Spea_1059 Spea_1054 Spea_1054 Spea_1053 Spea_1053 Spea_1028 Spea_1028 Spea_1013 Spea_1013 Spea_0966 Spea_0966 Spea_0965 Spea_0965 mdh mdh Spea_0837 Spea_0837 Spea_0735 Spea_0735 Spea_0718 Spea_0718 Spea_0695 Spea_0695 lpxL-2 lpxL-2 Spea_0561 Spea_0561 aroQ aroQ dapF dapF lysA lysA Spea_0010 Spea_0010 aroE aroE Spea_0050 Spea_0050 ppc ppc aroK aroK aroB aroB lpxL lpxL Spea_0338 Spea_0338 hutI hutI hutU hutU hutH hutH Spea_3894 Spea_3894 Spea_3872 Spea_3872
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Spea_3855PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; KEGG: cdf:CD3002 probable carbohydrate hydrolase. (393 aa)
Spea_3793PFAM: Sterol-binding domain protein; KEGG: slo:Shew_3374 protein of unknown function DUF1243. (207 aa)
Spea_3774PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: slo:Shew_0383 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). (416 aa)
Spea_3575PFAM: phenylalanine/histidine ammonia-lyase; KEGG: spc:Sputcn32_2431 phenylalanine/histidine ammonia-lyase. (558 aa)
astDAldehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (486 aa)
Spea_3490Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1064 aa)
Spea_3369PFAM: phenylalanine/histidine ammonia-lyase; KEGG: slo:Shew_2280 phenylalanine/histidine ammonia-lyase. (561 aa)
Spea_3227PFAM: ferredoxin-dependent glutamate synthase; SMART: zinc finger CDGSH-type domain protein; KEGG: vpa:VPA0765 putative glutamate synthetase. (514 aa)
maeAMalate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: slo:Shew_2962 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Belongs to the malic enzymes family. (562 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (274 aa)
Spea_3066Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa)
Spea_3014PFAM: amidohydrolase; KEGG: slo:Shew_0983 amidohydrolase. (459 aa)
dapDKEGG: slo:Shew_2638 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; PFAM: transferase hexapeptide repeat containing protein; Belongs to the transferase hexapeptide repeat family. (274 aa)
Spea_2858KEGG: slo:Shew_2587 hypothetical protein. (467 aa)
Spea_2857PFAM: amidohydrolase; KEGG: slo:Shew_2586 amidohydrolase. (1010 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa)
Spea_2551Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (312 aa)
astESuccinylglutamate desuccinylase/aspartoacylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (345 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (355 aa)
Spea_2186PFAM: beta-lactamase domain protein; KEGG: son:SO_A0149 hypothetical protein. (281 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (381 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
Spea_1942PFAM: NAD-glutamate dehydrogenase; KEGG: slo:Shew_1809 NAD-glutamate dehydrogenase. (1614 aa)
Spea_1921Aminodeoxychorismate lyase; PFAM: aminotransferase class IV; KEGG: shw:Sputw3181_1793 aminotransferase, class IV. (300 aa)
Spea_1794PFAM: ferredoxin-dependent glutamate synthase; KEGG: slo:Shew_1659 ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (550 aa)
Spea_1618TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: she:Shewmr4_1427 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (421 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
astBSuccinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (445 aa)
Spea_1066KEGG: slo:Shew_1079 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
Spea_1059TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: sbm:Shew185_1264 chorismate mutase. (657 aa)
Spea_1054TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: slo:Shew_1068 chorismate mutase. (384 aa)
Spea_1053Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (363 aa)
Spea_1028PFAM: protein of unknown function DUF339; KEGG: sfr:Sfri_2938 protein of unknown function DUF339. (79 aa)
Spea_1013PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: slo:Shew_1032 glutamate synthase (ferredoxin). (1482 aa)
Spea_0966TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: she:Shewmr4_2901 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (163 aa)
Spea_0965Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (117 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
Spea_0837Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa)
Spea_0735KEGG: slo:Shew_0779 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (456 aa)
Spea_0718KEGG: shm:Shewmr7_3380 hypothetical protein. (406 aa)
Spea_0695KEGG: shm:Shewmr7_3295 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (164 aa)
lpxL-2Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (308 aa)
Spea_0561KEGG: slo:Shew_0521 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (797 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
Spea_0010Amidohydrolase; PFAM: peptidase S9B dipeptidylpeptidase IV domain protein; amidohydrolase; WD40 domain protein beta Propeller; KEGG: slo:Shew_0013 amidohydrolase. (1066 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa)
Spea_0050KEGG: vfi:VF0144 sialic acid biosynthesis protein NeuD. (214 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (878 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa)
lpxLLipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (309 aa)
Spea_0338PFAM: phenylalanine/histidine ammonia-lyase; KEGG: son:SO_3299 Pal/histidase family protein. (550 aa)
hutIKEGG: slo:Shew_3759 imidazolonepropionase; TIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (414 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (562 aa)
hutHKEGG: slo:Shew_3756 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase; Belongs to the PAL/histidase family. (510 aa)
Spea_3894PFAM: phenylalanine/histidine ammonia-lyase; KEGG: slo:Shew_3517 histidine ammonia-lyase. (520 aa)
Spea_3872PFAM: amidohydrolase; Amidohydrolase 3; KEGG: vha:VIBHAR_06184 hypothetical protein. (419 aa)
Your Current Organism:
Shewanella pealeana
NCBI taxonomy Id: 398579
Other names: S. pealeana ATCC 700345, Shewanella pealeana ATCC 700345, Shewanella pealeana str. ATCC 700345, Shewanella pealeana strain ATCC 700345
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