(19 nodes) This domain is named PAZ after the proteins Piwi Argonaut and Zwille. This domain is found in two families of proteins that are involved in post-transcriptional gene silencing. These are the Piwi family and the Dicer family, that includes the Carpel ..., and siRNA-mediated gene silencing network (Oryza sativa Japonica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Input:
	A0A0P0WDW6	Os04g0572600 protein. (451 aa)
	A0A0P0XQV4	Os09g0555187 protein. (298 aa)
	DCL4	Endoribonuclease Dicer homolog 4; Involved in the RNA silencing pathway. Cleaves double- stranded RNA to produce small interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. Required for the production of 21 nucleotide siRNAs. Regulates shoot apical meristem (SAM) initiation and maintenance, leaf polarization and lemma polarity through the trans-acting siRNAS (ta-siRNAs) pathway, which probably modulate the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes. Can process endogenous 21 nucleotide siRNAs derived from an imperfect inverted repeat. Ma [...] (1657 aa)
	RDR1	Probable RNA-dependent RNA polymerase 1; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family. (740 aa)
	Q0IZR2_ORYSJ	Os09g0555200 protein. (318 aa)
	AGO4B	Protein argonaute 4B; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (911 aa)
	DCL2A	Endoribonuclease Dicer homolog 2a; Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs (By similarity). Belongs to the helicase family. Dicer subfamily. (1410 aa)
	DCL3A	Endoribonuclease Dicer homolog 3a; Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs (By similarity). (1651 aa)
	DCL2B	Endoribonuclease Dicer homolog 2b; Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs (By similarity). Belongs to the helicase family. Dicer subfamily. (1377 aa)
	AGO18	Protein argonaute 18; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (1088 aa)
	AGO1C	Protein argonaute 1C; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (1011 aa)
	AGO16	Protein argonaute 16; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (883 aa)
	AGO7	Protein argonaute 7; Involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta- siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes. (1048 aa)
	DCL3B	Endoribonuclease Dicer homolog 3b; Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs (By similarity). Belongs to the helicase family. Dicer subfamily. (1637 aa)
	RDR2	Probable RNA-dependent RNA polymerase 2; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family. (1136 aa)
	AGO2	Protein argonaute 2; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (1034 aa)
	AGO13	Protein argonaute 13; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (1192 aa)
	SHL2	Probable RNA-dependent RNA polymerase SHL2; Involved in the RNA silencing pathway. Probably required for the generation of small interfering RNAs (siRNAs). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta-siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes. (1218 aa)
	DCL1	Endoribonuclease Dicer homolog 1; Involved in the RNA silencing pathway. Cleaves double- stranded RNA to produce microRNAs (miRNAs) of 21-24 nucleotides which target the selective destruction of complementary RNAs. Regulates by this way the development of the plant. May not be involved in small interfering RNAs (siRNAs) production. (1883 aa)

Your Current Organism:

Oryza sativa Japonica

NCBI taxonomy Id: 39947
Other names: Japanese rice, Japonica rice, O. sativa Japonica Group, Oryza sativa (japonica cultivar-group), Oryza sativa Japonica Group, Oryza sativa subsp. japonica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0P0WDW6	AGO13	A0A0P0WDW6	Q852N2	Os04g0572600 protein.	Protein argonaute 13; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.587
A0A0P0WDW6	AGO16	A0A0P0WDW6	Q6YSJ5	Os04g0572600 protein.	Protein argonaute 16; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.705
A0A0P0WDW6	AGO18	A0A0P0WDW6	Q69UP6	Os04g0572600 protein.	Protein argonaute 18; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.584
A0A0P0WDW6	AGO1C	A0A0P0WDW6	Q6K972	Os04g0572600 protein.	Protein argonaute 1C; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.584
A0A0P0WDW6	AGO2	A0A0P0WDW6	Q7XTS4	Os04g0572600 protein.	Protein argonaute 2; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.612
A0A0P0WDW6	AGO4B	A0A0P0WDW6	Q0JF58	Os04g0572600 protein.	Protein argonaute 4B; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.600
A0A0P0WDW6	AGO7	A0A0P0WDW6	Q75HC2	Os04g0572600 protein.	Protein argonaute 7; Involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta- siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes.	0.661
A0A0P0WDW6	RDR1	A0A0P0WDW6	Q0DXS3	Os04g0572600 protein.	Probable RNA-dependent RNA polymerase 1; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family.	0.830
A0A0P0WDW6	RDR2	A0A0P0WDW6	Q7XM31	Os04g0572600 protein.	Probable RNA-dependent RNA polymerase 2; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family.	0.830
A0A0P0WDW6	SHL2	A0A0P0WDW6	Q8LHH9	Os04g0572600 protein.	Probable RNA-dependent RNA polymerase SHL2; Involved in the RNA silencing pathway. Probably required for the generation of small interfering RNAs (siRNAs). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta-siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes.	0.761
A0A0P0XQV4	AGO13	A0A0P0XQV4	Q852N2	Os09g0555187 protein.	Protein argonaute 13; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.587
A0A0P0XQV4	AGO16	A0A0P0XQV4	Q6YSJ5	Os09g0555187 protein.	Protein argonaute 16; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.705
A0A0P0XQV4	AGO18	A0A0P0XQV4	Q69UP6	Os09g0555187 protein.	Protein argonaute 18; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.584
A0A0P0XQV4	AGO1C	A0A0P0XQV4	Q6K972	Os09g0555187 protein.	Protein argonaute 1C; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.584
A0A0P0XQV4	AGO2	A0A0P0XQV4	Q7XTS4	Os09g0555187 protein.	Protein argonaute 2; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.612
A0A0P0XQV4	AGO4B	A0A0P0XQV4	Q0JF58	Os09g0555187 protein.	Protein argonaute 4B; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).	0.600
A0A0P0XQV4	AGO7	A0A0P0XQV4	Q75HC2	Os09g0555187 protein.	Protein argonaute 7; Involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta- siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes.	0.661
A0A0P0XQV4	RDR1	A0A0P0XQV4	Q0DXS3	Os09g0555187 protein.	Probable RNA-dependent RNA polymerase 1; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family.	0.830
A0A0P0XQV4	RDR2	A0A0P0XQV4	Q7XM31	Os09g0555187 protein.	Probable RNA-dependent RNA polymerase 2; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family.	0.830
A0A0P0XQV4	SHL2	A0A0P0XQV4	Q8LHH9	Os09g0555187 protein.	Probable RNA-dependent RNA polymerase SHL2; Involved in the RNA silencing pathway. Probably required for the generation of small interfering RNAs (siRNAs). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta-siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes.	0.761

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