STRINGSTRING
DCL4 DCL4 SGS3 SGS3 AGO7 AGO7 RDR2 RDR2 AGO2 AGO2 DCL1 DCL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
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gene fusions
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textmining
co-expression
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Your Input:
DCL4Endoribonuclease Dicer homolog 4; Involved in the RNA silencing pathway. Cleaves double- stranded RNA to produce small interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. Required for the production of 21 nucleotide siRNAs. Regulates shoot apical meristem (SAM) initiation and maintenance, leaf polarization and lemma polarity through the trans-acting siRNAS (ta-siRNAs) pathway, which probably modulate the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes. Can process endogenous 21 nucleotide siRNAs derived from an imperfect inverted repeat. Ma [...] (1657 aa)
SGS3Protein SUPPRESSOR OF GENE SILENCING 3 homolog; Required for post-transcriptional gene silencing and natural virus resistance; Belongs to the SGS3 family. (609 aa)
AGO7Protein argonaute 7; Involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta- siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes. (1048 aa)
RDR2Probable RNA-dependent RNA polymerase 2; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family. (1136 aa)
AGO2Protein argonaute 2; Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity). (1034 aa)
DCL1Endoribonuclease Dicer homolog 1; Involved in the RNA silencing pathway. Cleaves double- stranded RNA to produce microRNAs (miRNAs) of 21-24 nucleotides which target the selective destruction of complementary RNAs. Regulates by this way the development of the plant. May not be involved in small interfering RNAs (siRNAs) production. (1883 aa)
Your Current Organism:
Oryza sativa Japonica
NCBI taxonomy Id: 39947
Other names: Japanese rice, Japonica rice, O. sativa Japonica Group, Oryza sativa (japonica cultivar-group), Oryza sativa Japonica Group, Oryza sativa subsp. japonica
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