node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBI1 | DDB2 | Q9LWV9 | Q84KJ3 | cDNA clone:006-205-F10, full insert sequence. | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | 0.408 |
DDB2 | BBI1 | Q84KJ3 | Q9LWV9 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | cDNA clone:006-205-F10, full insert sequence. | 0.408 |
DDB2 | EXO1 | Q84KJ3 | Q60GC1 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | 0.853 |
DDB2 | FEN1A | Q84KJ3 | Q9SXQ6 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | Flap endonuclease 1-A; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts a [...] | 0.821 |
DDB2 | KU70 | Q84KJ3 | Q7F1M0 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU70, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA (By similarity). Required for the maintenance of chromosome stability and normal developmental growth. Plays a role in maintaining telomere length. Acts as a negative regulator in telomere homeostasis. | 0.709 |
DDB2 | KU80 | Q84KJ3 | Q75IP6 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | ATP-dependent DNA helicase 2 subunit KU80; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU70, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase (By similarity); Belongs to the ku80 family. | 0.704 |
DDB2 | MSH5 | Q84KJ3 | Q6L4V0 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | DNA mismatch repair protein MSH5; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossover (interference-sensitive crossover) formation. Belongs to the DNA mismatch repair MutS family. | 0.560 |
DDB2 | OJ1548_F12.18 | Q84KJ3 | P17070 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. | 0.480 |
DDB2 | POLL | Q84KJ3 | Q67VC8 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | DNA polymerase lambda; Repair polymerase involved in base excision repair (BER) and responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.447 |
DDB2 | UVR3 | Q84KJ3 | Q0E2Y1 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | (6-4)DNA photolyase; Involved in repair of UV radiation-induced DNA damage. Catalyzes the photoreactivation of pyrimidine [6-4] pyrimidone photoproduct (6-4 products) (By similarity). | 0.502 |
DDB2 | XRCC3 | Q84KJ3 | Q6YU07 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | Os02g0562100 protein. | 0.486 |
EXO1 | DDB2 | Q60GC1 | Q84KJ3 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | 0.853 |
EXO1 | FEN1A | Q60GC1 | Q9SXQ6 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | Flap endonuclease 1-A; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts a [...] | 0.891 |
EXO1 | KU70 | Q60GC1 | Q7F1M0 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU70, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA (By similarity). Required for the maintenance of chromosome stability and normal developmental growth. Plays a role in maintaining telomere length. Acts as a negative regulator in telomere homeostasis. | 0.963 |
EXO1 | KU80 | Q60GC1 | Q75IP6 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | ATP-dependent DNA helicase 2 subunit KU80; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU70, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase (By similarity); Belongs to the ku80 family. | 0.935 |
EXO1 | MSH5 | Q60GC1 | Q6L4V0 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | DNA mismatch repair protein MSH5; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossover (interference-sensitive crossover) formation. Belongs to the DNA mismatch repair MutS family. | 0.993 |
EXO1 | OJ1548_F12.18 | Q60GC1 | P17070 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. | 0.996 |
EXO1 | POLL | Q60GC1 | Q67VC8 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | DNA polymerase lambda; Repair polymerase involved in base excision repair (BER) and responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.932 |
EXO1 | XRCC3 | Q60GC1 | Q6YU07 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). | Os02g0562100 protein. | 0.908 |
FEN1A | DDB2 | Q9SXQ6 | Q84KJ3 | Flap endonuclease 1-A; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts a [...] | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity). | 0.821 |